1,721,186 research outputs found
Molecular and Cellular Mechanisms of Human Astrocytoma Progression: Advances in Knowledge to Reach Therapeutic Horizons
No full textHuman astrocytic tumors are primary central nervous system (CNS) tumors that arise either
from astrocytes or from precursor cells. A growing number of epidemiological and incidence studies
in dierent countries underlined that, in addition to increasing economic costs for health systems,
these cancers are still representing one of the main hurdles in developing a successful therapeutic
goal for patients. On the other hand, new-omics technologies are oering customized instruments
and more and more advantageous results toward personalized medicine approaches, underlining
the concept that each tumor mass undergoes a peculiar transformation process under the control of
specific genes’ and proteins’ functional signatures. The main aim of this Special Issue was to collect
novel contributions in the wide field of human tumor astrocytic basic and translational research, to
suggest further potential therapeutic targets/strategies that might interfere, possibly at the earliest
stage of transformation, with the tumor progression, and to increase the molecular-based arsenal to
counteract the prognostic poverty of high-grade astrocytic tumors
EXPERT REPORT ON THE QUALITY ASSURANCE OF THE PRODUCTION OF MEDICINES FROM BOVINE ORIGIN INCLUDING A RISK ASSESSMENT
No full text
SISTEMA PER LA RILEVAZIONE E LA QUANTIFICAZIONE DI DNA ESOGENO DI ORIGINE ANIMALE IN FARINE ALIMENTARI DESTINATE AL SETTORE ZOOTECNICO
No full textnumero domanda: M12004A000991
data deposito: 18 maggio 200
Autophagy and ionizing radiation in tumors: the “survive or not survive” dilemma
No full textAutophagy is a so-called ‘self-eating’ system responsible for degrading long-lived proteins and cytoplasmic organelles, whose products are recycled to maintain cellular homeostasis. This ability makes autophagy a good candidate for a survival mechanism in response to several stresses, including the tumor cell transformation. In particular, recent studies suggested that autophagy functions as a pro-death mechanism within different tumor contexts. It is however widely reported that autophagy represents both a survival mechanism or contributes directly to cell death fate. This interplay of the autophagy functions has been observed in many types of cancersand, in some cases, autophagy has been demonstrated to both promote and inhibit antitumor drug resistance. From a therapeutical point of view, the effects of the modulation of the tumor cell autophagic status, in responce to ionizing radiations, are presently of particular relevance in oncology. Accordingly, this review also provide a perspective view on future works for exploring the modulation of autophagic indices in tumor cells as a novel molecular-based adjuvant strategy, in order to improve radiotherapy and chemotherapy effects in cancer patients
Il ruolo della musicoterapia nel recupero del deficit uditivo. Un’indagine tra i professionisti che lavorano con bambini sordi e tra i fruitori.
No full textIn this study, two groups are interviewed: the first study includes a sample of 60 doctors and health providers in the field of deafness, whose opinion on music therapy is collected by a specific questionnaire, the second involves eight parents of deaf children attending music therapy lessons, who are asked to give an evaluation on the effect of music therapy, based on the experience of their children.
Results show that health professionals know very little about the rehabilitative effectiveness of music therapy, whereas the parents of deaf children give a positive evaluation on the psychological, behavioral and linguistic benefits that music therapy gives to their deaf children
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