178,005 research outputs found
Combi-TED: a new trial testing Tedopi R with docetaxel or nivolumab in metastatic non-small-cell lung cancer progressing after first line study protocol
No full textCombi-TED: a new trial testing Tedopi R with docetaxel or nivolumab in metastatic non-small-cell lung cancer progressing after first line study protocol </p
The impact of kombi-taxis on public transport
No full textIncludes bibliography.This thesis attempts to quantify the impact of kombi-taxis on the conventional modes of public transport, in particular the bus, in the Cape Town Metropolitan Area. The impact is quantified in terms of the resultant modal shift of commuters from the buses, trains, cars and walking, in favour of the kombi-taxi. The approach adopted involved a study of the kombi-taxi and bus operations and characteristics on the different kombi-taxi routes in the study area. Five representative routes were selected for a detailed study, involving an Observation survey and an Interview survey directed at the bus and kombi-taxi users on these routes. On a further 66 routes, a bus-taxi modal split survey was conducted. The findings of the study show• that the majority of present kombi-taxi users are former bus users. Conservatively, an estimated 30.6% of all the daily bus passenger trips have been lost to the kombi-taxi. The effect on trains has not been insignificant with an estimated 4.4% of all commuter train trips having been converted to kombi-taxi trips
MS2/Cardio: towards a multi-service medical software for cardiology
No full textMany clinics are interested to use software packages in daily practice, but lack of integration of such packages seriously limits their scope. In practice this often entails switching between programs and interrupting the run of an individual program. A multi-task approach would not solve this problem as it would not eliminate the need to input the same data many times, as often occurs when using separate packages. The construction of a Multi-Service Medical Software package (MSx2) is described, which was also developed as an example of practical integration of some clinically relevant functions. The package runs on a personal computer in an MS-DOS environment and integrates a time-oriented medical record management unit (TOMRU) for data of ambulatory patients, and a drug information management unit (DIMU) concerning posology, content, effects, and possible interactions. Of the possible database configurations allowed by MSx2, the cardiology patient database (MSx2/C) and hypertensive patient database (MSx2/H) were developed and described here. Clinical information to be included in the configurations was obtained after discussion and consensus of clinical practitioners. MSx2/C was distributed to several hundred clinical centers during computerized courses to train future users. MSx2 can easily transfer patient data to statistical processing packages
Restless legs syndrome and painful legs/moving toes
No full textRestless legs syndrome (RLS), which has been recently renamed Willis-Ekbom disease (WED), is a neurological disorder characterized by unpleasant sensations in the legs, with an urge to move. Symptoms mainly occur at rest in the evening or at night, and they are alleviated by moving the affected extremity. In the general population, a RLS prevalence of 5 % has been reported. Concerning the pathophysiology of RLS, some possible primary factors as brain iron deficiency, central nervous system dopamine regulation, and genetics have been identified. Recent guidelines indicated that pharmacological treatment should be limited to those patients who suffer from clinically relevant RLS, that is, when symptoms significantly impair the patient’s daytime functioning, quality of life, and sleep. In patients affected by chronic RLS, a nonergot dopamine agonist or an a-2-d calcium channel ligand are indicated. In the clinical practice, a dopamine agonist is more appropriate in case of depression and overweight presence. In case of comorbidities, such as chronic pain, anxiety, or insomnia, the a-2-d ligands should be considered. RLS symptoms that are present through large part of the day and night may favor the use of long-acting agents, such as the rotigotine patch or gabapentin enacarbil. In refractory RLS patients, oral prolonged release oxycodone-naloxone should be appropriate. Painful legs and moving toes syndrome (PLMTS) is a rare and underdiagnosed disorder. The pathophysiology of PLMTS is unknown, but most reports suggest an association with a peripheral lesion. Treatment is often unsatisfactory, but botulinum toxin and pramipexole showed long-term beneficial effect
Evaluating fuzzy association rules on XML documents
No full textIn this work we propose a flexible approach to evaluate association rules on XML documents. In particular we describe evaluation techniques in order to assign a satisfiability degree to structural association rules, which allow one to evaluate the similarity of the XML document with respect to a given structure, and to value association rules which allow one to capture the similarity between the information contained in the XML document and the required information
Sleep disorder-related headaches
No full textMigraine with and without aura, cluster headache, hypnic headache, and paroxysmal hemicranias are each reported as intrinsically related to sleep. Chronic migraine, chronic tension-type headache, and medication overuse headache may cause sleep disturbance. Otherwise, both headache and sleep disorder may be manifestations of a same systemic dysfunction. There is a vicious cycle linking sleep disorders and migraine. The poor quality or poor duration of sleep could be a trigger of migraine attack and migraineurs with poor sleep reported a higher headache frequency. Moreover, coping behaviors of migraineurs (e.g., going to sleep early to relieve migraine attacks) can be factors precipitating and perpetuating sleep disturbances themselves. During cluster headache, patients report a poor quality of sleep correlated with the amount of daylight. In particular, it was demonstrated that melatonin levels have influences on cluster headache attacks. Concerning the pathophysiology of hypnic headache, it has been hypothesized a possible role of obstructive sleep apnea in triggering nocturnal attacks: an increased number of apnea episodes has been reported in hypnic headache patients, but a lack of a temporal correlation of headache attacks with the drop of oxygen saturation has been observed. Tension-type headache is the most common headache with sleep dysregulation (lack of sleep or oversleeping) frequently reported as a triggering factor for acute attacks: management of sleep disturbances seems crucial in this form of headache
Complex Association Rules for XML Documents
No full textIn the XML data context, documents may have a "similar" content but a different structure, thus a flexible approach to identify recurrent situations is needed. In this work we show how it is possible to compose structural and value association rules (simple rules) in order to describe complex association rules on XML documents. Moreover, we propose an approach to quantify support and confidence both for simple and complex rules in the XML data context
Evaluation of Mechanical Properties by Electrostatic Loading of Polycristalline Silicon Beams
No full textThe Synergistic Relationship between Alzheimer's Disease and Sleep Disorders: An Update.
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