1,721,343 research outputs found

    Innovative Molecular Target and Therapeutic Approaches in Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis (NAFLD/NASH) 2.0

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    : Nonalcoholic fatty liver disease (NAFLD) is among the most common liver diseases worldwide, affecting up to 20-30% of the human population [...]

    Innovative Molecular Targets and Therapeutic Approaches in Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis (NAFLD/NASH) 3.0

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    : The aim of this Special Issue is to provide an update on the diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD), which is the most prevalent liver disease worldwide; however, there are still no specific treatment agents [...]

    Functional Design and Prototyping of a Novel Soft Fingertip with Variable Stiffness

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    The paper presents a novel soft fingertip for soft robotics application in greenhouses and protected cultivation. The system is designed to be easily adapted to different commercial end-effectors while not compromising their functionalities. The use of auxiliary vessels with combined air and liquid presence allows the adjustment of the fingertip stiffness to guarantee different values of exerted contact force and stiffness when compressed. A simplified design method to evaluate the influence of the membrane shape and the set-up parameters on the system behavior is reported. The method was compared with experimental measurements on a first system prototype

    Creative diversity: facing Anthropocene challenges fostering resilience capacities

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    Diversity and heterogeneity emerge as recurrent characteristics of resilient practices. The chapter moves from this perspective, emphasizing the relevance of creative diversity and redundancy proprieties' contribution to urban and territorial innovation. The creative diversity is the fil rouge adopted in retracing the resilience concept applied to territorial systems. The chapter reframes the resilience approaches focusing on the characterizing properties as inspirations in urban and territorial solutions design. It recognizes the creative diversity and redundancy as crosscutting properties that provide a common conceptual umbrella to the heterogeneous resilience practices and boost a more solid and explicit contribution of the resilience practices into the transition process toward more resilient, adaptive, and sustainable urban and territorial systems. The creative diversity is explored along four spheres connecting emerging approaches to urban public life, urban regeneration, and resilience practices. The four spheres or spaces for urban creative diversity are space for nature (ecological diversity and evolution and functional diversity of green spaces for wellness), space for social diversity (creativity of all and the functional creative diversity in public life), spaces for functional diversity (boosting creative economic diversity and urban models innovation), and organizational and creative diversity of governance processes and knowledge. The aim is to connect emerging phenomena from resilience practices geographies and promising action domains for urban resilience enhancement. © 2022 Elsevier Inc. All rights reserved

    Challenges for sustainability: fostering [eco]systems of resilience practices contribution

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    The chapter retraces the core themes characterizing the resilience practices' exploration proposed in the [Eco]system of Resilience Practices Book, emphasizing the core strategies to fostering the contribution of the practice toward long-term sustainable development goals at local and global levels boosting the resilience capacities of territorial and urban systems. Section 17.1 discusses the advancements emerging from the exploration of resilience practices presented in the book, moving from the core threats for commons and the institutional diversity that Elinor Ostrom envisaged. The aim is to compare the threats and barriers highlighted by Ostrom with the results from the resilience practices investigations presented, discussing the perspectives and the existing barriers. Section 17.2 focuses on the [eco]system of practices concepts as networking structures underlining perspectives to overcome the criticalities and dilemmas previously suggested and highlighted by the authors in presenting initiatives and conceptual reframing discourses. © 2022 Elsevier Inc. All rights reserved

    Organizational (creative) diversity. Dilemmas and perspectives of governance processes for complex systems resilience

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    The chapter aims to discuss the dilemma and outline advancements and perspectives on the relevance of organizational creative diversity in supporting the urban transition processes toward more sustainable, adaptive, and resilient urban complex systems focusing on the resilience practices contribution and role. The chapter assumes the relevant role and contribution of resilience practices in achieving sustainable development goals. Resilient practices are heterogeneous entities experimenting with creative solutions to address local emergencies implementing innovative models. The chapter investigates the crosscutting questions about the governance of the transition process, breaking up this wicked problem along with the scales of governance processes. The micro or endogenous scale refers to the quality and robustness of the process activated by single practice; the meso or endogenous scale includes the questions on networking among practices and the ones on integration with the institutional-led policies, programs, and plans. The macroscale addresses the theoretical and ethical questions that emerge assuming the "resilience practices" as the third actor in the governance process. The different scales imply different discourses on the governance of the socio-ecological system transformation process. In conclusion the chapter highlights the potentialities, focusing on the conditions and opportunities to recognize a role to resilient practices in long-term transition processes toward a more sustainable, resilient, aware, and adaptive society and territorial systems. © 2022 Elsevier Inc. All rights reserved
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