323,618 research outputs found
Aggiornamento sulla malattia di Hallervorden-Spatz
No full textLa neurodegenerazione con accumulo di ferro a livello cerebrale (NBIA, precedentemente definita come sindrome di Hallervorden-Spatz) comprende un gruppo di patologie neurodegenerative caratterizzate da disfunzioni extrapiramidali progressive (distonia, rigidità, coreoatetosi), accumulo di ferro nel cervello e presenza di sferoidi assonali, di solito limitati al sistema nervoso centrale
Subunit-association and functional properties in the hemocyanin of the squid Todarodes sagittatus.
No full textThe association-dissociation behaviour in Todarodes sagittatus hemocyanin has been studied by sedimentation velocity measurements
at different pH values and in the absence and presence of a
number of anions and cations. In the absence of salts the sedimentation
pattern is dominated (about 1002) by a relatively low M.W.
species (20 S), while 10 mM CaCl2 and increasing pH (above 65)
stabilize a larger (30 S) species.
The above data are used as a basic to explain some physiological questions concerning
the nutritional habits of these animals
A cost model for the economic evaluation of in-situ monitoring tools in metal additive manufacturing
Get PDFThe paper presents a cost model to evaluate the economic impact of defects and process instability in metal Additive Manufacturing (AM). The proposed model formulation adopts the main framework of previous seminal studies and extends it by considering the contribution of scrap fractions and in-situ monitoring performances on process and material costs, including pre- and post-processing operations. Three real industrial case studies (from dental, aerospace, and machinery sectors) were assessed to determine how the model can be used in the real industrial practice to (i) enhance the economic advantages of metal AM technologies by tackling process instability issues, (ii) assess the effectiveness of in-situ monitoring in the development of next generation metal AM systems, and (iii) define the performance specifications of in-situ monitoring solutions that yield sustainable cost savings in specific industrial applications. A further experimentation is presented to validate the cost model with respect to a benchmark reference
Temperature acclimation modulates the oxygen binding properties of the Atlantic cod (Gadus morhua L.) genotypes - HbI*1/1, HbI*1/2, and HbI*2/2.
No full textThe influence of long-term acclimation temperatures in Atlantic cod (Gadus morhua) was studied by growth experiments carried out over a total of 272 individuals. The attention focused on the structural and functional modulation of the five electrophoretically distinguishable genotypes of cod hemoglobin (HbI*1/1, HbI*1/2, HbI*2/2, HbI*1/2b, and HbI*2/2b) and on the correlation with body length/weight. The main results can be summarized as follows. (1) Acclimation to lower (4 and 8 °C) and higher (12 and 15 °C) temperatures favors the expression of, respectively, more anodic and more cathodic hemoglobin components. (2) The optimal O2 transporting features are observed at 12 °C, as well as a saturation-dependent temperature dependence of O2 binding, which furthermore is strongly dependent upon the acclimation background. (3) The optimal growth condition for the three main genotypes (HbI*1/1, HbI*1/2, and HbI*2/2) is associated with T=12 °C. The overall results are consistent with the idea that environmental temperatures constitute a primary factor in the aggregation of individuals physiologically more than genetically homogeneous. This is fully confirmed by careful statistical analysis carried out over a subset of individuals for which the full set of structural (isoelectric focusing), functional (O2 binding), and growth data was available
“Barriere sottomarine in medio Tirreno: un confronto in termini faunistici fra i risultati relativi al litorale di Agropoli (Sa) e quello di Salerno”
No full text
“Spettro faunistico di un tratto di litorale sabbioso in medio Tirreno (Salerno, Campania)”
No full textAllosteric formulation of thermal transitions in macromolecules, including effects of ligand binding and oligomerization.
No full textWe examine the effects of concentration (aggregation), buffers, and ligation, under conditions of either constant ligand activity or limited total amount of ligand, upon thermal denaturation of macromolecules as measured by scanning calorimetry. In doing so we utilize and extend an earlier generalized allosteric treatment [S. J. Gill, B. Richey, G. Bishop, and J. Wyman (1985) Biophys. Chem.21, 1–14], applicable to ligand binding, enthalpy changes, and volume changes in a macromolecular system. The approach is contrasted with formulations based on the idea of structural domains. We show how information from the full scanning calorimetric curves can be utilized in arriving at and testing appropriate models for observed behavior in selected examples
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