97,868 research outputs found
Morassutti e Wright, dalle esperienze americane alle esperienze indirette in una dimensione internazionale
No full textIl saggio redatto da Colombo e Scullica, illustra la poetica progettuale di Bruno Morassutti in relazione a Frank Lloyd Wright, presso cui Bruno Morassutti svolse un periodo di studio/apprendistato fra il 1949 e il 1951. Il saggio evidenzia le peculiarità delle influenze di Frank Lloyd Wright nelle realizzazioni di Morassutti, evidenziandone anche l'originalità nell'interpretazione. Dopo una parte generale sull'analisi del progettista, gli autori affrontano nel dettaglio alcuni casi studio specifici
Towards a general F-resolvent equation and Riesz projectors
No full textThe Fueter-Sce-Qian mapping theorem is a two steps procedure to extend holomorphic functions of one complex variable to quaternionic or Clifford algebra -valued functions in the kernel of a suitable generalized Cauchy-Riemann operator. Using the Cauchy formula of slice monogenic functions it is possible to write the Fueter-Sce-Qian extension theorem in integral form and to define the F-functional calculus for n-tuples of commuting operators. This functional calculus is defined on the S-spectrum and generates a monogenic functional calculus in the spirit of McIntosh and collaborators. One of the main goals of this paper is to show that the F-functional calculus generates the Riesz projectors. The existence of such projectors is obtained via the F-resolvent equation which was previously known only in the quaternionic setting and also its existence was under question. In this paper we prove the F-resolvent equation in the Clifford algebra setting. It is much more complicated than the one in the quaternionic case since it contains various pieces, however it still allows to nicely define the Riesz projectors. (C) 2022 Elsevier Inc. All rights reserved
The F -Resolvent Equation and Riesz Projectors for the F -Functional Calculus
No full textThe Fueter-Sce-Qian mapping theorem gives a constructive way to extend holomorphic functions of one complex variable to slice hyperholomorphic functions. By means of the Cauchy formula for slice hyperholomorphic functions it is possible to have a Fueter-Sce-Qian mapping theorem in integral form for n odd. On this theorem it is based the F-functional calculus for n-tuples of commuting operators. It is a functional calculus based on the commutative version of the S spectrum. Furthermore, it is a monogenic functional calculus in the spirit of McIntosh and collaborators. In this paper, inspired by the quaternionic case and some particular Clifford algebras cases, we show a general resolvent equation for the F-functional calculus in the Clifford algebra setting. Moreover, we prove that the F-resolvent equation is the suitable equation to study the Riesz projectors
Spazi di confidenza: la regolazione della distanza sociale nella collaborazione domestica
No full textNel contributo si cerca, innanzitutto, di
considerare l’attuale dibattito sul lavoro domestico anche alla
luce delle ricostruzioni che le discipline storiche ci offrono sul
ruolo che la servitù e il servizio domestico hanno svolto nelle
famiglie europee del passato, senza peraltro avere l’ambizione
di ricostruire un quadro completo o esauriente nelle poche
pagine a disposizione. Quindi, gli autori entrano nel vivo delle testimonianze
raccolte proponendo una differenziazione dei modelli
di relazione oggi prevalenti in Italia. Nelle conclusioni individuano alcune delle dimensioni di analisi che più
in profondità identificano le principali differenze riscontrate tra tali modelli. Il capitolo si basa sull’analisi di due sezioni
specifiche dell’intervista, relative alle relazioni con la famiglia
per cui si lavora e alle forme di cortesia utilizzate nell’ambiente
domestico. 2.503 citazioni tratte dalle 658 interviste sono state
quindi analizzate allo scopo di classificare tutte le interviste
sulla base delle dimensioni di analisi individuate
Moderating Urbanization and Managing Growth: How Can Colombo Prevent the Emerging Chaos?
No full textThis paper examines urbanization trends, the growth of Colombo and its present state of development. It looks at the approaches to the planned interventions in the city and demonstrates how a uni-directional urban development has had a detrimental impactColombo, urban development, managing urbanization, planning, housing,
Benzofuran Derivatives Activators of the Chaperone Protein Hsp90: Synthesis, Interaction Studies and Biological Effects
No full textWe have recently reported that allosteric modulation of the chaperone protein Hsp901 can be achieved in an allosteric fashion using a family of 2-phenyl-benzofuran derivatives that target an allosteric pocket at the C-terminal domain of the protein.2,3 These ligands are mainly activators of the chaperone ATPase activity3 and are accelerators of the protein internal dynamics.4 As a result, they tune Hsp90 chaperone activity in ways that we are just beginning to unravel.
We are going to present the synthetic approaches towards an expanded library of about 40 benzofuran derivatives diversified at positions R1 and R2 along with the interaction studies with full length Hsp905 and the effects on Hsp90 enzymatic and chaperoning activity.
Figure 1: 2-phenyl-benzofuran diversification at positions R1 and R2 (top) and docked complex of Hsc82 (Hsp90 yeast form) with one of our derivatives (bottom).
1. Jackson, S. E. In Molecular Chaperones; Jackson, S., Ed.; Springer Berlin Heidelberg: 2013; Vol. 328, p 155.
2. Morelli, L.; Bernardi, A.; Sattin, S. Carbohydr Res 2014, 390C, 33.
3. Sattin, S.; Tao, J.; Vettoretti, G.; Moroni, E.; Pennati, M.; Lopergolo, A.; Morelli, L.; Bugatti, A.; Zuehlke, A.; Moses, M.; Prince, T.; Kijima, T.; Beebe, K.; Rusnati, M.; Neckers, L.; Zaffaroni, N.; Agard, D. A.; Bernardi, A.; Colombo, G. Chem. Eur. J. 2015, 21, 13598.
4. Vettoretti, G.; Moroni, E.; Sattin, S.; Tao, J.; Agard, D. A.; Bernardi, A.; Colombo, G. Sci Rep 2016, 6, 23830.
5. Sattin, S.; Panza, M.; Vasile, F.; Berni, F.; Goti, G.; Tao, J.; Moroni, E.; Agard, D.; Colombo, G.; Bernardi, A. Eur. J. Org. Chem. 2016, DOI: 10.1002/ejoc.201600420
Synthesis and characterization of Hsp90 allosteric activators
No full textHsp90 is a molecular chaperone playing a pivotal role in the cell life cycle1 and an established anti-apoptotic target in cancer therapy.2 The protein internal dynamics are regulated by ATP and are critical for its function. We have recently demonstrated that Hsp90 can be modulated in an allosteric fashion, targeting the protein C-terminal domain (CTD) with a family of 2-phenyl-benzofuran derivatives.3-5 These molecules increase Hsp90 ATPase rate and accelerate its internal dynamics. As a result they tune its chaperone activity in ways that we are just beginning to unravel.
The synthetic approaches towards an expanded library of about 40 benzofuran derivatives diversified at positions R1 and R2 (Figure 1) will be presented together with the interaction studies with full length Hsp90.6
Figure 1: 2-phenyl-benzofuran diversification at positions R1 and R2.
1) Jackson, S. E. In Molecular Chaperones; Jackson, S., Ed.; Springer Berlin Heidelberg: 2013; Vol. 328, p 155-240.
2) Trepel, J.; Mollapour, M.; Giaccone, G. and Neckers, L., Nat Rev Cancer 2010, 10, 537-549.
3) Morelli, L.; Bernardi, A. and Sattin, S.*, Carbohydr. Res. 2014, 390, 33-41.
4) Sattin, S. et al Chem. Eur. J. 2015, 21, 13598-13608.
5) Vettoretti, G; Moroni, E.; Sattin, S.; Tao, J.; Agard, D. A.;. Bernardi, A. and Colombo, G. Sci Rep 2016, 6, 23830.
6) Sattin, S.*; Panza, M.; Vasile, F.; Berni, F.; Goti, G.; Tao, J.; Moroni, E.; Agard, D.; Colombo, G. and Bernardi, A. Eur. J.Org. Chem. 2016 DOI: 10.1002/ejoc.201600420
Inhabited Images: Drawing a New Life for Housing Complexes
No full text[EN] The theme of inhabiting in high-density buildings has been widely investigated since the Mid-Twentieth century. Still, original researches are now opening new perspectives, creating a common ground in which urban planning and architecture increasingly intersect with studies based on participation, urban policies and spatial justice. The failure of some of the iconic Twentieth-century architectures rose a strong debate that often resulted in their demolition. This process was primarily dictated by market logic, by a change in the residents and, above all, by the lack of all the services needed to build a community. Some experimental alternatives to replacing neglect building complexes have emerged especially in France and Northern Europe. The paper presents a selection of residential projects by Lacaton & Vassal, Mikhail Riches and LAN (Local Architecture Network), which use architectural drawings to propose innovative solutions to local administrations, as well as to initiate planning processes involving resident communities.Cristina F. Colombo authored paragraphs 2 and 3 and Viviana Saitto authored paragraphs 4. The introduction and the conclusions are a collaborative work.Colombo, CF.; Saitto, V. (2020). Inhabited Images: Drawing a New Life for Housing Complexes. EGE Revista de Expresión Gráfica en la Edificación. 0(13):64-77. https://doi.org/10.4995/ege.2020.14614OJS6477013Colombo, Cristina F. & Saitto, Viviana. 2018. Utopia S.r.l.: Icone sconfitte dell'housing sociale. Siracusa: LetteraVentidue. ISBN 978-88-6242-201-7.Druot, Frédéric, Lacaton, Anne & Vassal, Jean-Philippe. 2007. Plus: La vivienda colectiva: territorio de excepción / Les grands ensembles de logements: Territoire d'exception / Large-scale Housing Development: An Exceptional Case. Barcelona: Editorial Gustavo Gili. ISBN 978-84-252-2163-7.Eco, Umberto. 1962. Opera aperta: Forma e indeterminazione nelle poetiche contemporanee. Milan: Bompiani. ISBN 88-452-4545-4.Gulinello, Francesco & Mucelli, Elena. 2020. Modelli: Costruire lo spazio/Models: Building the Space. Siracusa: LetteraVentidue. ISBN 978-88-62424-22-6.Hickman, M. 2020. "Separating the Inseparable: Picasso Murals Removed from Oslo Office Building as Demolition Work Begins". The Architect's Newspaper (July 28, 2020). https://www.archpaper.com/2020/07/picasso-murals-removed-from-oslo-office-building-asdemolition-work-begins/?fbclid=IwAR2-tTwj1Zj5Q5WgzNEJF6kUU_5kbaTliBs2vqOLudIfr0zWQTPwde_bGAoHistoric England. 2015. "Robin Hood Gardens Estate". https://historicengland.org.uk/whats-new/news/robin-hood-gardens/Lacaton, Anne. 2018. "Lacaton & Vassal: Open Conditions for Permanent Change. Interview with Anne Lacaton". Materia Arquitectura no. 18, pp. 22-29. ISSN 0718-7033.LAN. 2016. "Il miglioramento della qualità delle periferie esistenti come mezzo per gestire rabbia e risentimento sociale: L'operato di LAN (Local Architecture Network) in Francia". In Aa. Vv. Reporting from the front: Biennale di Architettura 2016: Guida. Venice: Marsilio. ISBN: 978-88-317-2409-8Purini, Franco. 1996. "Una lezione sul disegno: Come si agisce/Dentro l'architettura". In Cervellini, Franco & Partenope, Renato, eds. Franco Purini: Una lezione sul disegno. Rome: Gangemi editore. ISBN 887-86-413.Rogers, T. 2017. "Picasso Murals Caught Up in Terrorist Attack's Bitter Legacy". The New York Times (October 19, 2017). https://www.nytimes.com/2017/10/19/arts/oslo-picasso-mural.htmlRossi, Lamberto. 1988. Giancarlo De Carlo: Architetture. Milan: Arnoldo Mondadori Editore. ISBN 978-88-0431-185-0.Rovelli, Carlo. 2017. L'ordine del tempo. Milan: Adelphi. ISBN 978-88-459-3192-5.Ruby, Andreas & Ruby, Ilka. 2007. "Introduction: Reclaiming Modernism". In Druot, Frédéric, Lacaton, Anne & Vassal, Jean-Philippe. Plus: La vivienda colectiva: Territorio de excepción / Les grands ensembles de logements: Territoire d'exception / Large-scale Housing Development: An Exceptional Case. Barcelona: Editorial Gustavo Gili. ISBN 978-84-252-2163-7.Smithson, Alison, ed. 1968. Team 10 Primer. London: Studio Vista.Smithson, Alison. 1982. "Urban Re-identification". In Id., ed., The Emergence of Team 10 out of CIAM. London: Architectural Association, p. 7. ISBN 09-04-50315-1.Woods, Shadrach. 1968. "Stem". In A. Smithson, Alison, ed., Team 10 Primer. London: Studio Vista, pp. 37-40. (Reprinted form Architectural Design (May 1960), p. 181).Zevi, Bruno. 2009. Saper vedere l'architettura: Saggio sull'interpretazione spaziale dell'architettura. Milan: Einaudi. ISBN 978-88-062-0106-7
Introduzione. La sfida dell'integrazione culturale per i rifugiati, i richiedenti asilo e i minori stranieri non accompagnati
No full textPresentazione del secondo Quaderno CIRMIB della Collana Inside Migration, che raccoglie alcuni dei contributi presentati nel corso della sessione di Sociologia dell’Educazione Rifugiati e minori stranieri non accompagnati di fronte al sistema scolastico e formativo in Italia (Catania, 5 ottobre 2018), nell’ambito della Mid-term Conference della Associazione Italiana di Sociologia (AIS)
- …
