2,858 research outputs found
Disturbo post-traumatico da stress e disturbo depressivo maggiore nelle vittime di rapina
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Letter from A.L. Monmerqué de Courmont.
No full textLetter from A.L. Monmerqué de Courmont, possibly Adélaïde Louise de Monmerqué (1767-1835) who had been married to Louis Marie Le Bas de Courmont (1741-1794), dated 10 pluvoise. It is not addressed but was presumably sent to Philippe-Antoine Merlin, as it comprises the verso of one of his requisitions from 1802. In this letter the author requests a day and an hour when she (or he) might meet with the recipient
Iron and insulin resistance
No full textBACKGROUND: Preliminary clinical and experimental results suggest that iron can modify hepatocytes' insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling.
AIM: To evaluate in vivo the influence of iron on insulin resistance and insulin release in patients with non-alcoholic fatty liver disease and in vitro the interaction between iron and insulin sensitivity by analysing the effect of iron manipulation on insulin receptor expression in hepatoblastoma HepG2 cell line.
RESULTS: Insulin resistance evaluated by homeostatis model assessment (HOMA)-insulin resistance significantly decreased after diet, and a further reduction was observed after phlebotomies. Iron depletion by desferrioxamine increased by twofold the 125I-insulin-specific binding, whereas iron addition reduced insulin binding, similarly to cells exposed to high glucose concentration.
CONCLUSION: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver diseas
Iron and insulin resistance
No full textBackground: Preliminary clinical and experimental results suggest that iron can modify hepatocytes' insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling. Aim: To evaluate in vivo the influence of iron on insulin resistance and insulin release in patients with nonalcoholic fatty liver disease and in vitro the interaction between iron and insulin sensitivity by analysing the effect of iron manipulation on insulin receptor expression in hepatoblastoma HepG2 cell line. Results: Insulin resistance evaluated by homeostatis model assessment (HOMA)-insulin resistance significantly decreased after diet, and a further reduction was observed after phlebotomies. Iron depletion by desferrioxamine increased by twofold the 125I-insulin-specific binding, whereas iron addition reduced insulin binding, similarly to cells exposed to high glucose concentration. Conclusion: Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with nonalcoholic fatty liver disease
Spotted wing drosophila: notes on dynamics in Lombardy (Italy) and susceptibility of some small fruits=Drosophila suzukii: note sulle dinamiche in Lombardia (Italia) e sulla suscettibilità di alcuni piccoli frutti
No full textL'attività sperimentale eseguita nel primo anno di questa tesi di dottorato è parte di un progetto più ampio denominato GEISCA finanziato dal MIUR nel bando Prin 2010-2011. Durante il primo anno di attività ci si è occupati di Drosophila suzukii (Matsumura, 1931) (Dip: Drosophilidae) un insetto da quarantena invasivo (Suss e Costanzi, 2010), presente in Italia dal 2008 (Grassi et a.l, 2009; Raspi et al., 2011), che danneggia fortemente sia i frutti di bosco che frutta con nocciolo. L’attività sperimentale ha riguardato la valutazione del periodo di volo di D. suzukii e di altri drosophilidi nativi. Inoltre è stata valutata il tasso attrattività di differenti specie di piccoli frutti e varietà diverse.The experimental activity executed during this doctorate thesis was Drosophila suzukii (Matsumura, 1931) which is part of a bigger project GEISCA, financed by Italian Ministry for Education, University and Research in PRIN 2010-2011. The first detection of this hazardous quarantine pest (Suss and Costanzi, 2010) was first detected in 2009 by Grassi et al., but backdated to 2008 by Raspi et al in 2011. The result of the experimental activity of the first year of this study refers to field activity, included evaluation of D. suzukii flight period and its attractiveness to different soft fruits
Relationship between early vascular damage and physical exercise in patients with non alcoholic fatty liver disease
No full textThe aim of this work was to study the effects of different bile acids on the permeability of gap junction channels (PGJC). We also looked at the effects of some bile acids on the coordination of intercellular calcium oscillations. The permeability of gap junctions was assessed by fluorescent dye transfer and calcium signalling on fluorescent microscopy. Cholestatic bile acids such as taurolithocholate, taurolithocholate-sulfate and taurochenodeoxycholate inhibit the permeability of gap junctions in a dose-dependent and reversible manner in hepatocytes. Experiments performed in other cell types suggest that this effect is specific for cells having bile salt transporters, independently of the type of connexin expressed in these cells. Thus, cholestatic bile acids inhibit PGJC in normal rat cholangiocytes which express Cx43, but not in HeLa cells transfected with Cx26 or 32, which are expressed in hepatocytes. Calcium oscillations induced by bile acids in rat hepatocyte couplets are not coordinated and, by inhibiting the PGJC, cholestatic bile acids prevent the coordination of calcium oscillations induced by noradrenaline in these cells. Cholestatic, but not choleretic bile acids inhibit the PGJC in cells able to accumulate bile acids. This inhibition might contribute to the cholestatic effect of these bile acids
Prevalence and natural history of portal vein thrombosis, evaluated by contrast enhanced ultrasonography (CEUS), in patients with hepatocellular carcinoma
No full textEffect of iron depletion liver function and insulin resistance in patients with NASH and fatty liver
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S.L.I.M., a small linear interdependent model of eight EU-member states, the USA and Japan
No full textInternational Economics;EU
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