65,220 research outputs found
Bullous pemphigoid localized to the mouth
No full textDescrizione di caso clinico di pemfigoide bolloso localizzato al cavo oral
Studio comparativo dell’associazione calcipotriolo-microemulsioni in pazienti affetti da psoriasi.
No full textLymphomatoid-like contact dermatitis from cobalt naphthenate
No full textDescrizione di caso clinico di dermatite allercica da contatto da cobalto naftenate con pattern linfomatoid
Adaptive response of microglial cells to in vitro infection by Candida albicans isolates with different genomic backgrounds
No full textIt has been recently demonstrated that Candida albicans isolates with distinct genomic backgrounds (namely, b and c genotypes)
express different susceptibility to antifungal activity by human monocytes in vitro. We show here that, although comparable in their ability to undergo dimorphic transition and in susceptibility to phagocytosis by microglial cells, the b and c isolates show striking differences in terms of intracellular survival. Only the c genotype resists indeed to intracellular killing and eventually replicates inside microglial cells, that in turn respond to fungal infection, preferentially towards the c genotype, with nuclear factor-kB (NF-kB) activation and increased Mip1a production. These data indicate that C. albicans-microglial cell interaction is strictly dependent upon fungal genotype, strengthening the potential significance of genotyping as prognostic parameter in clinical infections by C. albicans
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Role of iron load on fibrogenesis in chronic hepatitis C
No full textBACKGROUND/AIMS: In chronic viral hepatitis, an enhanced iron load is related to lower response to interferon. Furthermore, iron, through the production of oxygen radicals, may stimulate hepatocyte necrosis and the activation of cells responsible for synthesis and deposition of extracellular matrix. We investigated the relationship between iron load, evaluated by serum assays, and liver fibrogenesis in chronic active viral hepatitis. METHODOLOGY: Serum iron, ferritin, transferrin saturation and serum markers of hepatic fibrogenesis (Laminin and the amino-terminal peptide of procollagen III-NPIIIP-) were assayed in 102 patients (47 females, 55 males, mean age 42.48 years) affected by chronic hepatitis C virus and in 81 healthy controls (47 males, 34 females). In hepatitis C virus patients (studied before alpha-interferon treatment) a semiquantitative score for portal inflammation, necrosis and fibrosis was applied to liver biopsy. RESULTS: Serum indices of iron load were higher in hepatitis C virus patients than in controls, and were higher in cirrhotic than in chronic hepatitis cases. Ferritin and serum iron were positively correlated with NPIIIP and laminin; moreover cases with ferritin levels over the normal limit for sex and age had higher levels of NPIIIP and laminin than cases with normal or poor iron status. CONCLUSIONS: Our data suggest that even a mild increase of iron load stimulates hepatic fibrogenesis, probably adding oxygen free radical injury to the damage of viral infection
Clinical and Histopatological Findings in a Family With Hemochromatosis Type 3, Carrying a New Mutation in Transferrin Receptor 2 Gene
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Extracapillary proliferative glomerulonephritis and pulmonary purpura in a patient with rheumatoid arthritis treated with gold salts
No full textExtracapillary proliferative glomerulonephritis and pulmonary purpura in a patient with rheumatoid arthritis treated with gold salt
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