142 research outputs found
Emeline Renz, CSCJ Supplemental Assignments, Spring 2020
No full textCSCJ Supplemental Assignments, Spring 2020. Submitted by Emeline Renz, GIS Coordinator, Sociology and Criminal Justice Department, Clark Atlanta University
Emeline Renz, Clark Atlanta University, April 20, 2020
No full textStatement submitted by Emeline Renz, GIS Coordinator (Faculty/Staff), Sociology and Criminal Justice Department, Clark Atlanta University
Prevalence and impact of COVID-19 sequelae on treatment pathways and survival of patients with cancer who recovered from SARS-Cov-2 infection: results from the OnCovid registry.
No full textretrospective, registry study David J Pinato, Josep Tabernero, Mark Bower, Lorenza Scotti, Meera Patel, Emeline Colomba, Saoirse Dolly, Angela Loizidou, John Chester, Uma Mukherjee, Alberto Zambelli, Alessia Dalla Pria, Juan Aguilar-Company, Diego Ottaviani, Amani Chowdhury, Eve Merry, Ramon Salazar, Alexia Bertuzzi, Joan Brunet, Matteo Lambertini, Marco Tagliamento, Anna Pous, Ailsa Sita-Lumsden, Krishnie Srikandarajah, Johann Colomba, Fanny Pommeret, Elia Segui, Daniele Generali, Salvatore Grisanti, Paolo Pedrazzoli, Gianpiero Rizzo, Michela Libertini, Charlotte Moss, Joanne S Evans, Beth Russell, Nadia Harbeck, Bruno Vincenzi, Federica Biello, Rossella Bertulli, Raquel Lilian, Sabrina Rossi, Maria Carmen Carmona-Garcia, Carlo Tondini, Laura Fox, Alice Baggi, Vittoria Fotia, Alessandro Parisi, Giampero Porzio, Maristella Saponara, Claudia Andrea Cruz, David Garcia-Illescas, Eudald Felip, Ariadna Roque Lloveras, Rachel Sharkey, Elisa Roldan, Roxana Reyes, Irina Earnshaw, Daniela Ferrante, Javier Marco-Hernandez, Isabel Ruiz-Camps, Gianluca Gaidano, Andrea Patriarca, Riccardo Bruna, Anna Sureda, Clara Martinez-Vila, Ana Sanchez de Torre, Luca Cantini, Marco Filetti, Lorenza Rimassa, Lorenzo Chiudinelli, Michela Franchi, Marco Krengli, Armando Santoro, Aleix Prat, Mieke Van Hemelrijck, Nikolaos Diamantis, Thomas Newsom-Davis, Alessandra Gennari, Alessio Cortellini, on behalf of the OnCovid study group
Addition of Primary Metastatic Site on Bone, Brain, and Liver to IMDC Criteria in Patients With Metastatic Renal Cell Carcinoma: A Validation Study
No full textInternational Metastatic Renal Cell Carcinoma Database Consortium (IMDC) criteria are a key element by which the choice of systemic treatment is decided. However, heterogeneity may exist among IMDC risk categories. The first site of metastatic disease occurrence is related to overall survival. The addition of this variable to the others within the recognized IMDC score improves prognosis prediction.Background: The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) criteria have been largely adopted in clinical practice. In a recent retrospective study, we assessed that the addition of the first site of metastatic disease to brain, bone, and liver improves prognostic stratification of patients with metastatic renal cell carcinoma (mRCC). Here, we performed an external validation in patients with mRCC. Our aim was to evaluate if the addition of a new independent variable could improve IMDC prognosis prediction and reduce heterogeneity within risk categories. Patients and Methods: We selected all 1073 patients treated at a single institution for mRCC and included in the Institute Gustave Roussy Renal Cell Carcinoma database. All patients included received at least 1 line of targeted therapy or immune checkpoint inhibitors. Univariate and multivariate analyses (Cox regression model) were performed. Bootstrap validation of the final model was also carried out for internal validation. The IMDC modified classification was defined by the addition of the seventh variable, and we defined the modified IMDC good-risk criteria as 0 risks, intermediate-risk as 1 to 2 risks, and poor-risk as 3 or more risks. Results: The presence of brain, bone, and/or liver as the first site of metastatic disease plus the other variables included in the IMDC score were statistically significant variables associated with overall survival (OS) after univariate and multivariate analysis and bootstrap validation. Finally, 122 (15%) patients had a modification of their initial risk category. The median OS in the poor-, intermediate-, and favorable-risk groups was 10, 26, and 52 months, respectively (P < .001). The bias-corrected concordance index in patients receiving immune checkpoint inhibitors (n = 241) was 0.71. Conclusion: The addition of brain, bone, and/or liver metastases as an additional variable to the other IMDC variables improves the prognostic predictive power of the model
Susan Glaspell’s Poetics and Politics of Rebellion, Iowa City, University of Iowa Press, 2017, 258 p
No full textInternational audience“In Susan Glaspell’s Poetics and Politics of Rebellion, Emeline Jouve has cleared away what Lawrence Langer once called Glaspell’s ‘old lace’ to reveal the ‘steel lining beneath the tender surface’—the politics and, really, outrage at injustice and belief in democratic idealism that are at the center of Glaspell’s dramaturgy—and her raison d’être as a writer.”—Drew Eisenhauer, Coventry UniversityA pioneer of American modern drama and founding member of the Provincetown Players, Susan Glaspell (1876–1948) wrote plays of a kind that Robert Brustein defines as a “drama of revolt,” an expression of the dramatists’ discontent with the prevailing social, political, and artistic order. Her works display her determination to put an end to the alienating norms that, in her eyes and those of her bohemian peers, were stifling American society. This determination both to denounce infringements on individual rights and to reform American life through the theatre shapes the political dimension of her drama of revolt.Analyzing plays from the early Trifles (1916) through Springs Eternal (1943) and the undated, incomplete Wings, author Emeline Jouve illustrates the way that Glaspell’s dramas addressed issues of sexism, the impact of World War I on American values, and the relationship between individuals and their communities, among other concerns. Jouve argues that Glaspell turns the playhouse into a courthouse, putting the hypocrisy of American democracy on trial. In staging rebels fighting for their rights in fictional worlds that reflect her audience’s extradiegetic reality, she explores the strategies available to individuals to free themselves from oppression. Her works envisage a better future for both her fictive insurgents and her spectators, whom she encourages to consider which modes of revolt are appropriate and effective for improving the society they live in. The playwright defines social reform in terms of collaboration, which she views as an alternative to the dominant, alienating social and political structures. Not simply accusing but proposing solutions in her plays, she wrote dramas that enacted a positive revolt.A must for students of Glaspell and her contemporaries, as well as scholars of American theatre and literature of the first half of the twentieth century
sj-docx-1-tam-10.1177_17588359211053416 – Supplemental material for COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359211053416 for COVID-19 in breast cancer patients: a subanalysis of the OnCovid registry by Laia Garrigós, Cristina Saura, Clara Martinez-Vila, Alberto Zambelli, Mark Bower, Barbara Pistilli, Matteo Lambertini, Diego Ottaviani, Nikolaos Diamantis, Ailsa Lumsden, Sonia Pernas, Daniele Generali, Elia Seguí, Gemma Viñas, Eudald Felip, Ana Sanchez, Gianpiero Rizzo, Armando Santoro, Alessio Cortellini, Ylenia Perone, John Chester, Maria Iglesias, Marta Betti, Bruno Vincenzi, Michela Libertini, Francesca Mazzoni, Federica Zoratto, Rossana Berardi, Annalisa Guida, Rachel Wuerstlein, Angela Loizidou, Rachel Sharkey, Juan Aguilar Company, Marta Matas, Chiara Saggia, Lorenzo Chiudinelli, Emeline Colomba-Blameble, Myria Galazi, Uma Mukherjee, Mieke Van Hemelrijck, Mar Marin, Carla Strina, Aleix Prat, Helena Pla, Eva Maria Ciruelos, Alexia Bertuzzi, Lucia del Mastro, Giampiero Porzio, Thomas Newsom-Davis, Isabel Ruiz, Maria Belen Delany, Marco Krengli, Vittoria Fotia, Alessandro Viansone, Neha Chopra, Margarita Romeo, Ramon Salazar, Ignacio Perez, Francesca d’Avanzo, Michela Franchi, Manuela Milani, Fanny Pommeret, Marco Tucci, Paolo Pedrazzoli, Nadia Harbeck, Daniela Ferrante, David J. Pinato and Alessandra Gennari in Therapeutic Advances in Medical Oncology</p
D. Stuttard (ed.), Looking at Medea: Essays and a translation of Euripides’ tragedy
No full text"Euripides’ Medea is one of the most often read, studied and performed of all Greek tragedies": such an introduction of the great Greek classics by Bloomsbury, the publisher of Looking at Medea. Essays and a translation of Euripides’ tragedy raises great expectations. Is it possible, in 2014, to offer new significant insights into Euripides’ most discussed play? Founder of the theatre company Actors of Dionysus, editor or author of several books on Ancient Greek drama and translator, David St..
Integrating somatics and meditation into dance curriculum
No full textIt can feel impossible to find time to add moments of healthful relaxation to an already crowded dance schedule, but it's something that can enhance a dancer's body and mind. Many universities offer a few courses in somatic techniques, but often they are minimal. The author proposes series of daily classes be offered to dance majors, consisting of Improvisation or Gaga Technique, Stretch and Conditioning, Mindful Meditation, Yoga, and Foam Roller coupled with Self and Partner Massage
Diversities and Disparities in Endometrial Carcinoma (EC): Clinicopathological Features and Outcomes from Indigenous Populations, a French Multicentric Retrospective Study
No full textBackground: Disparities in access to cancer care remain a significant issue. Cancer epidemiology in the French overseas territories differs significantly from mainland (FRANCIM 2019 data). Indigenous populations are underrepresented in clinical trials, and little is known about their profiles and outcomes. This study reports on the clinicopathological features of EC patients from Martinique, Guadeloupe (French west Indies), French Polynesia (FP), Wallis and Futuna (WF) and Reunion Island. Methods: We conducted a multicentric retrospective study of EC patients treated in the aforementioned mentioned territories. Results: We included 1040 patients. Three distinct groups emerged from our analysis, each corresponding to specific geographical area. Patients from the South Pacific islands (FP and WF) were younger and predominantly obese compared to those in mainland France. The most common histological subtype was endometrioid, usually diagnosed at an early stage. In contrast, nearly 45% of patients from the FWI presented had non-endometrioid subtypes and were diagnosed at more advanced stages. Patients from Reunion showed clinical characteristics similar to those of Caucasian patients in mainland France (Table 1). Conclusion: The French overseas territories face unique challenges in the management of endometrial cancer. Progression-free survival rates are significantly lower compared to mainland France. These populations are underrepresented in research, and mainland guidelines are often extrapolated to them, despite their specific characteristics. Studying these populations more closely would allow for tailored treatment strategies and help reduce ethnic disparities.Contexte : Les disparités d'accès aux soins contre le cancer demeurent un problème majeur. L'épidémiologie des cancers dans les territoires français d'outre-mer diffère de celle de la France hexagonale (FRANCIM 2019). Les populations autochtones sont sous-représentées dans les essais cliniques, et leurs profils clinico-pathologiques sont peu connus. Cette étude analyse les caractéristiques clinicopathologiques des patientes atteintes de cancer de l'endomètre en Martinique, Guadeloupe (Antilles françaises), Polynésie française (PF), Wallis-et-Futuna (WF) et La Réunion. Méthodes : Nous avons mené une étude rétrospective multicentrique dans les territoires cités. Résultats : 1040 patientes, ont été incluses. Les patientes des îles du Pacifique Sud (PF et WF) étaient plus jeunes et principalement obèses. Le sous-type histologique dominant était l’endométrioïde, généralement diagnostiqué à un stade précoce. En revanche, près de 45 % des patientes des Antilles présentaient des sous-types non endométrioïdes à des stades plus avancés. Les caractéristiques des patientes de La Réunion étaient similaires à celles des patientes caucasiennes de France hexagonale. Conclusion : Les territoires d'outre-mer font face à des défis uniques pour la prise en charge du cancer de l'endomètre, avec des taux de survie sans progression inférieurs à ceux de France hexagonale. Ces populations, sous-représentées dans la recherche, nécessitent des stratégies de traitement adaptées pour réduire les disparités ethniques
Exercise training to reduce cardiovascular risk in patients with metabolic syndrome and type 2 diabetes mellitus: How does it work?
No full textMetabolic syndrome (MetS) – a clustering of pathological conditions, including abdominal obesity, hypertension, dyslipidemia and hyperglycaemia – is closely associated with the development of type 2 diabetes mellitus (T2DM) and a high risk of cardiovascular disease.
A combination of multigenetic predisposition and lifestyle choices accounts for the varying inter-individual risk to develop MetS and T2DM, as well as for the individual amount of the increase in cardiovascular risk in those patients. A physically active lifestyle can offset about half of the genetically mediated cardiovascular risk. Yet, the extent to which standardized exercise programmes can reduce cardiovascular risk differs between patients. Exercise parameters, such as frequency, intensity, type and duration or number of repetitions, differentially target metabolic function, vascular health and physical fitness. In addition, exercise-induced molecular mechanisms are modulated by other patient-specific variables, such as age, diet and medication.
This review discusses the molecular and cellular mechanisms underlying the effects of exercise training on cardiovascular risk specifically in patients with MetS and T2DM.The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: NK, MB and MD are supported by the German Centre for Cardiovascular Research (DZHK, partner sites Berlin (NK) and Greifswald (MB, MD)). EMVC is supported by the Fund for Scientific Research Flanders
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