101,993 research outputs found
Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the diseas
No full textAbstract
BACKGROUND/AIMS:
In chronic viral hepatitis, liver biopsy is performed for assessing disease activity and fibrosis. In this study, we evaluated the impact of the size of liver biopsy on the grading and staging.
METHODS:
We selected 161 liver biopsies from patients with chronic types B and C hepatitis on the basis of their length (> or =3 cm) and width (1.4 mm). Ishak scoring system was used for grading and staging. The score was blindly repeated reducing the length of the specimen from > or =3 to 1.5 cm and to 1 cm long and width from 1.4 to 1 mm.
RESULTS:
Reducing the length of the biopsy led to an increase of cases with mild grades: 49.7% in > or =3 cm, 60.2% in 1.5 cm and 86.6% in 1 cm long specimens (P or =3 cm, 68.3% in 1.5 cm and 80.1% in 1 cm long specimens (P<0.001). As for the width, both grade and stage were significantly underscored in the 1 mm samples, regardless of their length.
CONCLUSIONS:
Liver biopsy size strongly influences the grading and staging of chronic viral hepatitis. The use of fine needles should be discouraged in this setting
Clinical practice and ideal liver biopsy sampling standards: Not just a matter of centimeters
No full textThe development of Protophormia terraenovae (Robineau- Desvoidy) (Diptera, Calliphoridae) and its micromorphology from egg to adult
No full textIl "Duello" e la "pace". G. Muzio, G. B. Pigna, G. B. Susio a Marzio di Colloredo (10 novembre 1563-7 luglio 1575)
No full textIl contributo presenta e pubblica lettere inedite (autografi) di Girolamo Muzio (2: 1563-64), di Gio. Battista Pigna (1: 1565), di Gio. Battista Susio (2: 1570-75) in materia di duello a Marzio di Colloredo traendole dal cod. Bartoliniano 151 della Biblioteca Arcivescovile di Udine, dove si leggono, una di seguito all'altra, ai ff. 40r-50r
Quantitative analysis of IgM anti-HBc in chronic hepatitis B patients using a new "gray-zone" for the evaluation of "borderline" values
No full text
Long-term monthly follow-up of patients with chronic anti-HBe positive hepatitis B treated with different interferon types and schedules
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