29,814 research outputs found
Joy Collins
No full textGuest of honour, Joy Collins AM, with from left: Sybil Franklin; Mavis Blackadder; Dagmar Brautigam; Thelma Waters.Collins, Joy
Mapping a gene for rheumatoid arthritis on chromosome 18q21
No full textAlthough single chi-square analysis of the North American Rheumatoid Arthritis Consortium (NARAC) data identifies many single-nucleotide polymorphisms (SNPs) with p-values less than 0.05, none remain significant after Bonferroni correction. In contrast, CHROMSCAN evades heavy Bonferroni correction and auto-correlation between SNPs by using composite likelihood to model association across all markers in a region and permutation to assess significance. Analysis by CHROMSCAN identifies a 36-kb interval that includes the most significant SNP (msSNP) observed in a 10-Mb target suggested by linkage. Unexpectedly, stratification by gender and age of onset shows that association evidence comes almost entirely from females with age of onset less than 40. Combining evidence from a meta-analysis of linkage studies and three subsets of the NARAC data provides significant evidence for a determinant of rheumatoid arthritis in a 36-kb interval and illustrates the principle that estimates of location and its information are more powerful than estimates of p-values alone
Combined segregation and linkage analysis of Graves-disease with a thyroid autoantibody diathesis
No full textCombined segregation and linkage analysis is a powerful technique for modeling linkage to diseases whose etiology is more complex than the effect of a well-described single genetic locus and for investigating the influence of single genes on various aspects of the disease phenotype. Graves disease is familial and is associated with human leukocyte antigen (HLA) allele DR3. Probands with Graves disease, as well as close relatives, have raised levels of thyroid autoantibodies. This phenotypic information additional to affection status may be considered by the computer program COMDS for combined segregation and linkage analysis, when normals are classified into diathesis classes of increasing thyroid autoantibody titer. The ordinal model considers the cumulative odds of lying in successive classes, and a single additional parameter is introduced for each gene modeled. Distributional assumptions are avoided by providing estimates of the population frequencies of each class. Evidence for linkage was increased by considering the thyroid autoantibody diathesis and by testing two-locus models. The analysis revealed evidence for linkage to HLA-DR when the strong coupling of the linked locus to allele DR3 was considered (led score of 6.6). Linkage analysis of the residual variation revealed no evidence of linkage to Gm, but a suggestion of linkage to Km
Protecting Animals 36: Author Witi Ihimaera
No full textIn this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship
Vom Herzschlag der Zebrafische
No full textFunktioniert der Herzmuskel vielleicht doch anders, als die Forschung seit Jahren annimmt? Die Biologin Michelle Collins will das herausfinden, indem sie Fischherzen durchleuchtet
Blog Post, I am USF St. Petersburg: Cyndie Collins, November 24, 2004
No full textA blog post from the series I am USF St. Petersburg about members of the University of South Florida St. Petersburg (USFSP). Cyndie Collins began her advising duties in the College of Education at USFSP. In 1997, she became the first director of the Academic Advising Center that handles undergraduate advising across all USFSP colleges
Evaluating reinforcement learning for game theory application learning to price airline seats under competition
No full textApplied Game Theory has been criticised for not being able to model real decision making situations. A game's sensitive nature and the difficultly in determining the utility payoff functions make it hard for a decision maker to rely upon any game theoretic results. Therefore the models tend to be simple due to the complexity of solving them (i.e. finding the equilibrium).In recent years, due to the increases of computing power, different computer modelling techniques have been applied in Game Theory. A major example is Artificial Intelligence methods e.g. Genetic Algorithms, Neural Networks and Reinforcement Learning (RL). These techniques allow the modeller to incorporate Game Theory within their models (or simulation) without necessarily knowing the optimal solution. After a warm up period of repeated episodes is run, the model learns to
play the game well (though not necessarily optimally). This is a form of simulation-optimization.The objective of the research is to investigate the practical usage of RL within a simple sequential stochastic airline seat pricing game. Different forms of RL are considered and compared to the optimal policy, which is found using standard dynamic programming techniques. The airline game and RL methods displays various interesting phenomena, which are also discussed. For completeness, convergence proofs for
the RL algorithms were constructed
All de world am sad adn dreary, Ev'rywhere I roams [first line of chorus]
No full textstrophic with choruspiano and voice (solo and satb chorus)No.389 Musical BouquetJohns Hopkins University, Levy Sheet Music Collection, Box
068, Item 076[Stephen Collins Foster
South Korea's experience with external debt
No full text노트 : This paper is chapter 3 in S. 14. Collins and W. A. Park, "External Debt and Macroeconomic Adjustment in South Korea" in J. Sachs (ed.) Developing Country Debt; The Country Studies, submitted to the University of Chicago Press for publication consideration. The author would like to thank Won Am Park, Vittorio Corbo and Anne Krueger for their comments. Financial support from an NBER Olin Fellowship is gratefully acknowleged. This research was supported by the National Science Foundation and is part of NEER's research program in International Studies. Any opinions expressed are those of the authors and not those of the National Bureau of Economic Research
All de world am sad adn dreary, Ev'rywhere I roams [first line of chorus]
No full textstrophic with choruspiano and voice (solo and satb chorus)No.389 Musical BouquetJohns Hopkins University, Levy Sheet Music Collection, Box
068, Item 076[Stephen Collins Foster
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