1,509 research outputs found
Angus Collins
No full text"Angus. Collins Darwin Infantry Battalion Jan 41 - July 42 19th Aust. Infantry Battalion 2nd A.I.F. July 42 Aug 45 [signature] A.C.Collins Rous Mill N.S.W. 2477".Angus Collins. Darwin Infantry Battalion, January 41 - July 42. 19th Australian Infantry Battalion, 2nd Australian Imperial Forces, July 42 August 45. [signature] A.C.Collins. Rous Mill, New South Wales 2477.Date:199
1964 year book [Angus M. Woodbury]
No full textDiary kept by zoologist Angus M. Woodbury during the year 1964, during which he continued in editing and drafting of a report on his Dugway research. He also continued work on his family history project. With his wife Grace, Woodbury traveled to Fort Collins to begin his work as an instructor of high school biology teachers. His last entries describe his teaching procedures and relations with his classes
1963 year book [Angus M. Woodbury]
No full textDiary kept by zoologist Angus M. Woodbury during the year 1963, during which he was engaged in numerous research programs for the U.S. National Parks Service, including at Capitol Reef, Dinosaur National Monument and the proposed Canyonlands park. He continued his study of the Flaming Gorge and Glen Canyon dam areas, and continued to prepare a report on his research at Dugway. He also worked on a family history manuscript. Woodbury accepted a position as an instructor for high school biology teachers at Colorado State University in Fort Collins. He also commented on the assassination of President Kennedy
The skeletal ciliopathies
No full textWithin the broad and growing spectrum of human ciliopathies is a range of linked and overlapping disorders that present with skeletal features. These have been coined the skeletal ciliopathies. The syndromes have, to this point, been largely attributed to alterations in cellular Hedgehog signalling during development. However, a huge surge in fundamental discovery and clinical research has unveiled a plethora of roles for cilia in biology. This implicates a range of molecular and cell processes in the pathogenesis of skeletal ciliopathies. Our understanding of bi-directional interactions between cilia and the extracellular matrix remains in its infancy. The identification of genes and causal mutations defines skeletal ciliopathies. Some of these genes, and the proteins they encode, are now being explored further, by means of cell, animal, and other model approaches, seeking to understand the molecular underpinnings of disease. However, given the relatively recent appreciation of links between cilia biology and human disease, there is much work to be done. This chapter will briefly introduce the primary cilium and its associated ‘ciliome’, before describing the ciliary-associated skeletal disorders and the genes with which they are associated. Where possible, it will expand upon our current mechanistic understanding.</p
Gubernatorial candidates Joseph Brennan, Susan Collins and Angus King all have f
No full textGubernatorial candidates Joseph Brennan, Susan Collins and Angus King all have full-time paid staff and campaign offices, and that they expect to spend well over 100,000 on his campaign and will purchase no television ads, leading some to wonder if the party is serious about winning the election. Details, Green Party platform
Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1–mediated endocytosis
No full textMatrix protease activity is fundamental to developmental tissue patterning and remains influential in adult homeostasis. In cartilage, the principal matrix proteoglycan is aggrecan, the protease-mediated catabolism of which defines arthritis; however, the pathophysiologic mechanisms that drive aberrant aggrecanolytic activity remain unclear. Human ciliopathies exhibit altered matrix, which has been proposed to be the result of dysregulated hedgehog signaling that is tuned within the primary cilium. Here, we report that disruption of intraflagellar transport protein 88 (IFT88), a core ciliary trafficking protein, increases chondrocyte aggrecanase activity in vitro. We find that the receptor for protease endocytosis in chondrocytes, LDL receptor–related protein 1 (LRP-1), is unevenly distributed over the cell membrane, often concentrated at the site of cilia assembly. Hypomorphic mutation of IFT88 disturbs this apparent hot spot for protease uptake, increases receptor shedding, and results in a reduced rate of protease clearance from the extracellular space. We propose that IFT88 and/or the cilium regulates the extracellular remodeling of matrix—independently of Hedgehog regulation—by enabling rapid LRP-1–mediated endocytosis of proteases, potentially by supporting the creation of a ciliary pocket. This result highlights new roles for the cilium’s machinery in matrix turnover and LRP-1 function, with potential relevance in a range of diseases.—Coveney, C. R., Collins, I., Mc Fie, M., Chanalaris, A., Yamamoto, K., Wann, A. K. T. Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1–mediated endocytosis
Republican gubernatorial candidate Susan Collins received a campaign letter from
No full textRepublican gubernatorial candidate Susan Collins received a campaign letter from independent candidate Angus King, in which King criticized Collins and indicated that the race for governor was a two-man affair pitting King against Democrat Joseph Brennan. Collins wrote King back, and said she was astonished that he would tell Republicans to abandon her candidacy because of an early September poll. Details
Maine’s Gubernatorial Candidates Present Their Positions on Health Care Reform
No full textFew issues have dominated the public policy agenda in the last decade as health care reform has in 1994. Although health care reform is stalled in Congress at this writing, it is not an issue that will exit the public stage quickly or quietly. Mainefaces many of the problems that have spurred the national health care debate. The state has made some attempts to address these through public policy. But larger health care issues remain unresolved and the next governor will most certainly play a major role in addressing those issues. Maine Policy Review invited the four major candidates seeking to become the state’s next chief executive to present their views on health care reform for publication in this issue. Three of the four candidates, Jonathan Carter, Susan Collins and Angus King, responded to that invitation. Their statements on health care reform are presented in this articl
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