1,849 research outputs found
Multidrug Resistance-Associated Protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of mycophenolic acid in renal transplant recipients
No full textZ.I. Md Dom, I.S. Westley, J.K. Coller, A.A. Somogyi , B.C. Sallusti
J.K. Rowling: Her Life and Works
No full textBiographical information on author J.K. Rowling, a bibliography of her works, and a selection of her tweets
J.K. Rowling: Her Life and Works
No full textBiographical information on author J.K. Rowling, a bibliography of her works, and a selection of her tweets
Quidditch: J.K. Rowling's Leveler
No full textInterviewed regarding the first of the hugely successful series of magic and science fiction novels and screen adaptations about a rather unusual schoolboy named Harry Potter studying to be a wizard, author J.K. Rowling says she was intrigued by the possibility of “ … a sport for wizards, and I’d always wanted to see a game where there was more than one ball in play at the same time. The idea just amused me. The author continued to explain that she imagined Quidditch as being most like her favorite spectator sport, basketball (Amazon.co.uk interview, 2001). Except, of course, the players in Quidditch ride flying broomsticks and play with four bewitched balls. Apart from explaining in detail the bizarre rules and techniques of this supernatural game, this article examines some of the more significant sociological aspects of the sport that are far rarer (and, one might add, more ideologically desirable) in everyday human (or "Muggles") sports. Quidditch is a true leveler; matches are entirely non-segregated. They can have players of either gender and player’s ages in the same match can range from pre-teen to adult. As such, the game serves as a most ideal literary innovation in establishing early in the series of Harry Potter novels the eponymous hero as an ‘Every-adolescent’ who any young reader, male or female, can identify with. The game's popularity as such has seen it play an important role in each of the novel’s sequels and screen adaptation's inter-personal conflicts and has also spawned a successful - if short-lived - fan-base in the medium of the computer game
A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis
No full textAIM: To establish a method suitable for diagnostic genotyping of CYP2D6 alleles by DNA sequencing. METHODS: Initial PCR reactions were performed to specifically amplify exons 3, 4, 5 and 6 of the CYP2D6 gene using primers previously published. New primers were used to identify *2, *3, *4, *6, *7, *8, *9 and *41 in 2 sequencing reactions. Additional primers were designed for reverse sequencing in samples with 1 or 3 b.p. deletions. Previously published assays were used to detect *5, *10 and *16 alleles to complete genotype assignment. RESULTS: We reliably detected the nonfunctional alleles, *3, *4, *6, *7 and *8, which are associated with the poor metabolizer phenotype, and 2 important alleles associated with decreased enzyme activity, *9 and *41. Observed allele frequencies were comparable to those found previously in Caucasian populations. CONCLUSION: CYP2D6 genotype has been shown in previous clinical studies to be a good predictor of CYP2D6 phenotype and, therefore, related to therapeutic response and the risk of drug toxicity. This genotyping method is simple and reliable, and, therefore, can be routinely performed on an isolated patient sample, providing a relatively quick turnaround time needed for clinical practice. In addition, the simultaneous drawing of blood with the commencement of drug therapy will allow dosage adjustment on the basis of the CYP2D6 genotype to reduce the risk of adverse drug reactions.H.M. James, J.K. Coller, D. Gillis, J. Bahnisch, B.C. Sallustio and A.A. Somogy
Magic in British society reflected in J.K Rowling's Harry Potter and The Sorcerer's Stone
No full textABSTRACT
The substance of principal discussion in this research is projected to investigate ” Magic in British Society reflected in J.K.Rowling’s Harry Potter and the Sorcerer’s Stone.” Through this research, the researcher analyze about the relation between magic in the real condition of British culture which portrayed in Harry Potter novel.
This study is conducted to reach an understanding and detailed explanation describe “Magic” as a culture and belief in British culture 18th century which portrayed in Harry Potter novel by J.K Rowling. Magic in British have aim since at the ancient era, but most popular during 18th century. Some anthropologist have some proofs to make strong about the concept, such as E.B Tylor. E.B Tylor, the Anthropologist in the last 19th century was founded some tool mediator of magic, such as wand, fly broom in Wales, write of spell, card divination, voodoo doll in Ireland, etc. from the Biographical of the author, J.K Rowling used the concept of the anthropologist theory above. J.K Rowling was inspired into her novel. J.K Rowling used magic in the Harry Potter novel to portrayed the social life in British society during 18th century.
This study is conducted by applying the literary criticism which analyze and interpret the reflection of magic in Harry Potter novel from magic as a culture in social life in British society during 18th century. The data are in the form of the text of novel, Harry Potter itself that authored by J.K Rowling. The data are analyzed firstly by analyzing the magic as a culture in British society during 18th century which was portrayed in the novel based on the E.B Tylor’s theory about social culture anthropology. Then, analyzing and interpreting the data concerning the biography of J.K Rowling as the author of the novel based on E.B Tylors’s theory about social culture anthropology. Finally, relating two analyses before and interpreting their relation.
Data analysis revealed some findings covering the formulated research problems. This study found that magic in British society have aim since at the ancient era until 18th century, but most popular during 18th century. Magic in the novel is reflection from the real condition in British social life during 18th century. The author of the Harry Potter novel J.K Rowling was adapted that condition into her novel. So, there is a relationship between magic in British society as portrayed in the Novel Harry Potter and that in the social life of British society in 18th
"J.K. Rowling Spent Her Saturday Pissing Off The Internet" : - En diskursanalys om cancelkultur i mediaartiklar kring J.K. Rowling.
No full textThis study examines the phenomena of cancel culture, and the cancellation of author J.K Rowling during June 2020. Cancel culture is a world spread phenomenon which is widely discussed and has been heavily criticized for limiting the freedom of speech as well as embraced for creating a way for marginalized groups to influence the public debate. The aim is to analyze the cancellation process of Rowling through articles and discourse, and answering the question; How is cancel culture expressed in articles regarding the case of J.K Rowling? The study’s theoretical framework is based on Michel Foucault’s theories on discourse, power and knowledge and is closely connected with the methodological approach, a Foucauldian discourse analysis. The analyzed units consist of a selection of nine articles regarding the specific case. The analysis resulted in three main themes; Actors and power relations, Presentation of norms, and Presentations of J.K Rowling, through which the cancellation process is analyzed. The conclusions can be summarized as follows: cancel culture takes its form in the articles by presenting Rowling mainly negatively, expressing why her standpoints are problematic, as well as challenging existing power structures. At the same time the results reveal that a cancellation is complex and can take form in different ways. Our contribution to the research field is to provide further understanding for the specific case. Hopefully our results, in combination with other studies, can contribute to deeper understanding of the phenomena of cancel culture.
Taludbekleding van gezette steen onder golfaanval: Invloed van de doorlatendheid van de fundering. Verslag modelonderzoek
No full textIn het kader van het onderzoek naar de golfbelasting op een taludbekleding van gezette steen werd tijdens de 96 vergadering van werkgroep 1 van de Technische Adviescommissie voor de Waterkeringen, d.d. 30 november 1978, besloten het Waterloopkundig Laboratorium opdracht te verlenen modelonderzoek uit te voeren betreffende de invloed van de doorlatendheid van de fundering op de stabiliteit van de taludbekleding. Het onderzoek werd in de maanden januari en februari 1979 uitgevoerd in de 1 m brede. Scheldegoot van het Laboratorium de Voorst. Het onderzoek stond onder leiding van ir. J.K. Kostense, die tevens dit verslag samenstelde.Steenzettingen - TAW/EN
Memo from J.K. Corbett to Mr. Joe Carroll, Relocation Officer, Heart Mountain on Monday, June 12, 1944
No full textMemorandum of understanding from J. K. Corbett to Joe Carroll regarding a meeting of the Powell Club in Powell, Wyoming.The Japanese American Archival Collection documents the people, places, and daily life of Japanese Americans, primarily those who lived in the once thriving community of pre-war Florin in the Sacramento region, as well as the conditions in American incarceration camps during World War II. The approximately 7,000 original items include personal and official letters, photographs, diaries, arts and crafts, newsletters, textiles, camps artifacts, yearbooks and other publications
Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation
No full textLink to a related website: https://link.springer.com/content/pdf/10.1007/s12664-020-01114-y.pdf, Open Access via UnpaywallGastrointestinal inflammation is a hallmark of highly prevalent disorders, including cancer treatment–induced mucositis and ulcerative colitis. These disorders cause debilitating symptoms, have a significant impact on quality of life, and are poorly managed. The activation of toll-like receptor 4 (TLR4) has been proposed to have a major influence on the inflammatory signalling pathways of the intestinal tract. Inhibition of TLR4 has been postulated as an effective way to treat intestinal inflammation. However, there are a limited number of studies looking into the potential of TLR4 antagonism as a therapeutic approach for intestinal inflammation. This review surveyed available literature and reported on the in vitro, ex vivo and in vivo effects of TLR4 antagonism on different models of intestinal inflammation. Of the studies reviewed, evidence suggests that there is indeed potential for TLR4 antagonists to treat inflammation, although only a limited number of studies have investigated treating intestinal inflammation with TLR4 antagonists directly. These results warrant further research into the effect of TLR4 antagonists in the intestinal tract.Janine S. Y. Tam, Janet K. Coller, Patrick A. Hughes, Clive A. Prestidge, Joanne M. Bowe
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