936 research outputs found
Control of the blood–brain barrier function in cancer cell metastasis
No full textCerebral metastases are the most common brain neoplasms seen clinically in the adults and comprise more than half of all brain tumours. Actual treatment options for brain metastases that include surgical resection, radiotherapy and chemotherapy are rarely curative, although palliative treatment improves survival and life quality of patients carrying brain-metastatic tumours. Chemotherapy in particular has also shown limited or no activity in brain metastasis of most tumour types. Many chemotherapeutic agents used systemically do not cross the blood-brain barrier (BBB), whereas others may transiently weaken the BBB and allow extravasation of tumour cells from the circulation into the brain parenchyma. Increasing evidence points out that the interaction between the BBB and tumour cells plays a key role for implantation and growth of brain metastases in the central nervous system. The BBB, as the tightest endothelial barrier, prevents both early detection and treatment by creating a privileged microenvironment. Therefore, as observed in several in vivo studies, precise targetting the BBB by a specific transient opening of the structure making it permeable for therapeutic compounds, might potentially help to overcome this difficult clinical problem. Moreover, a better understanding of the molecular features of the BBB, its interrelation with metastatic tumour cells and the elucidation of cellular mechanisms responsible for establishing cerebral metastasis must be clearly outlined in order to promote treatment modalities that particularly involve chemotherapy. This in turn would substantially expand the survival and quality of life of patients with brain metastasis, and potentially increase the remission rate. Therefore, the focus of this review is to summarise the current knowledge on the role and function of the BBB in cancer metastasis
The symbols in the poetry of ruben dario
No full text碩士本論文主要分為三個章節，第一章，何為象徵符號？本章節主要藉由象徵理論學家，威爾伯 (Wilbur Marshall Urban)、弗萊(Northrop Frye)、托多羅夫(Tzvetan Todorov)、賽洛特(Juan-Eduardo Cirlot)以及其他學者的相關文獻解釋象徵符號的定義以及象徵符號在文學作品中的定義。
第二章針對達里歐的生平、作品以及達里歐在現實主義時期的重要性為論述重點。筆者根據達里歐的生平以及生長年代來了解他的作品特色，達里歐一生多采多姿，尤其感情方面更為豐富，這些人生際遇皆影響達里歐的寫作風格。達里歐不只是詩人，也是歷史的見證者，從他的作品中可以看到政治歷史的變化趨勢。達里歐著作極為豐富，筆者在本章節挑選三本可以代表達里歐的作品：《藍》(Azul)、《每日詩》(Prosas profanes)以及《生命與希望之歌》(Cantos de vida y esperanza)。達里歐與現實主義有著密不可分的關係，他的寫作風格不僅受到現實主義作家的影響，同時也是影響現實主義作家的重要人士之一。
第三章筆者不僅針對達里歐的詩集作品分析，同時也分析其散文作品，如《稀奇》(Los raros)。筆者將經常出現於達里歐作品中的象徵符號分為三個部分：顏色符號、禽鳥符號和寶石符號。顏色符號部分主要分析的顏色為藍色、綠色、白色以及黑色。禽鳥符號則針對天鵝、鴿子、孔雀和老鷹。而最後的寶石符號則以珠寶、寶石、鑽石、琥珀、黃金和水晶為主要分析內容。
最後筆者希望藉由這篇論文的研究，能讓大家了解象徵符號經由作家的詮釋，即使相同的符號，也擁有不同的意義。此外也希望大家能透過此篇論文認識文學史上重要的拉丁美洲作家盧本達里歐先生。In this thesis we explore definitions of symbols and the life of the author in the book of Ruben Dario. Dario is an author who emphasized the importance of the use of symbols though out his books. Therefore we might consider him as a master specialized in writing with symbols.
We divide the thesis into three chapters. In the first chapter, we give details to the definition of the symbols. According to scholars like Urban, Frye, Todorov and Cirlot, we are able to understand symbols in forms of signs, images and words. The concept of the symbols is relatively comprehensive, taking into consideration that a symbol is not always a sign; in fact, it is much more than a sign.
In the second chapter, we describe Ruben Dario about his life, literary works and the times when he lived. His life was interesting, colorful and varied. He was not only a poet but a public figure, having been an ambassador of Nicaragua in Spain. Dario wrote many pieces and each was important to him. Based on his narration, there are three books that can represent Ruben Dario, Azul, Prosas profanas and Cantos de vida y esperanza.
Dario was the master of Modernism, mainly because of the great influence of Latin America. Not only did Ruben Dario influence the poets of Modernism but was influenced by other poets in the same period.
In the last chapter we examine the symbols in the poetry of Dario and we divided the symbols into three parts: the colors, birds and precious stones. The first part, we examine the colors. There are blue, green, and black. In the second part, we deal with the symbols of birds, including swans, pigeons, peacocks and eagles. And in the last part, we talk about precious stones. We analyze the symbols of agate, ruby, diamond, crystal and gold. Finally, we end up with the conclusions and bibliography.INTRODUCCION 1
Motivo y objetivo 1
Metodologia de trabajo 3
CAPITULO I: ¿QUE SON LOS SIMBOLOS? 5
1.1 Teorias del simbolo 6
1.2 Los simbolos en la literatura 15
CAPITULO II: RUBEN DARIO Y SU OBRA POETICA 22
2.1 Vida 22
2.2 Obra literaria 28
2.3 Ruben Dario y el Modernismo 35
CAPITULO III: LOS SIMBOLOS EN LA POESIA DE RUBEN DARIO 40
3.1 Colores 40
3.2 Aves 45
3.3 Piedras preciosas 59
CONCLUSION 72
BIBLIOGRAFIA 77
ANEXOS 83學號: 698120028, 學年度: 10
Robot-assisted replacement of the refractory components of the ladle sliding gate in a steel shop
No full textRobots are wide spread in most industrial sectors and relieve operators from cumbersome, repetitive and sometimes harmful operations. In the steel sector the implementation of human-robot-cooperation is hampered and slowed down by harsh environmental conditions in some applications, as well as by intrinsic difficulties of some operations, which require a combination of force and precision and need to be supervised and acknowledged by the technical personnel due to strict safety regulations. The paper presents an ad-hoc designed robotic workstation, which has been developed and installed in the steel shop of an Italian steel company, representing one of the first attempts to establish a collaborative environment where a robot supports the technical personnel in a complex and delicate maintenance operation. The purpose of the robotic cell is to support the inspection, cleaning and replacement operations of the refractory components of the so-called “sliding gate”, namely the device allowing the liquid steel to flow from the ladle to the tundish of the continuous casting. The robotic cell includes a vision system supporting the different operations, and a Human Machine Interface, which facilitates the interaction between the robot and the operators and helps to improve the qualitative performance of the whole process. Within such a course, the sequence and new division of human-robot activities were thoroughly developed within an innovation process integrating the future users and operators (embedding technological innovation within a social innovation process)
Erratum: Author Correction: A Lab-in-a-Fiber optofluidic device using droplet microfluidics and laser-induced fluorescence for virus detection (Scientific reports (2022) 12 1 (3539))
No full textCorrection to: Scientific Reports https://doi.org/10.1038/s41598-022-07306-0, published online 03 March 2022
The original version of this Article contained an error in the spelling of the author Ruben R. G. Soares, which was incorrectly given as Ruben G. Soares
As Cores de Ruben A.: o processo de escrita de «Verde» e «Pardos»
No full textA presente tese tem como objetivo testar uma tipologia de emendas que ainda só foi aplicada à obra de Camilo Castelo Branco e caracterizar o processo criativo de Ruben A.. Como tal, procedeu-se à análise genética de dois contos do autor, «Verde» e «Pardos», que ainda não foram estudados e que demonstram que, de facto, a tipologia de emendas utilizada pode ser aplicada a Ruben A., embora precise de ser ampliada para uma análise genética mais abrangente.The current dissertation has the objective of testing the typology of errors that has only been applied to the work of Camilo Castelo Branco and characterize the creative process of Ruben A.. Therefore, a genetic analysis was carried out of two short stories by the author, «Verde» and «Pardos», that haven’t yet been studied and that evidence that, as a matter of fact, the typology of errors used can be applied to all authors, even though it needs to be expanded to further a comprehensive analysis
As Cores de Ruben A.: o processo de escrita de «Verde» e «Pardos»
No full textA presente tese tem como objetivo testar uma tipologia de emendas que ainda só foi aplicada à obra de Camilo Castelo Branco e caracterizar o processo criativo de Ruben A.. Como tal, procedeu-se à análise genética de dois contos do autor, «Verde» e «Pardos», que ainda não foram estudados e que demonstram que, de facto, a tipologia de emendas utilizada pode ser aplicada a Ruben A., embora precise de ser ampliada para uma análise genética mais abrangente.The current dissertation has the objective of testing the typology of errors that has only been applied to the work of Camilo Castelo Branco and characterize the creative process of Ruben A.. Therefore, a genetic analysis was carried out of two short stories by the author, «Verde» and «Pardos», that haven’t yet been studied and that evidence that, as a matter of fact, the typology of errors used can be applied to all authors, even though it needs to be expanded to further a comprehensive analysis
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