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Photograph - Sports - events and facilities. Peter Spence (standing), Ron Steiner and Colin McKenzie (on mat)
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/290646Sports - events and facilities. Peter Spence (standing), Ron Steiner and Colin McKenzie (on mat)310024
Item: [2003.0003.07709] "Photograph - Sports - events and facilities. Peter Spence (standing), Ron Steiner and Colin McKenzie (on mat)
A comparative study on the immunogenicity of live and inactivated Salmonella typhimurium vaccines in mice
Full text linkThe articles have been scanned in colour with a HP Scanjet 5590; 300dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Mice were very successfully immunized against intraperitoneal infection with virulent Salmonella typhimurium by fluid and lyophilized formalin inactivated vaccines prepared from a smooth strain of the microorganism. A single subcutaneous injection of 0,2 ml containing 0,1% packed cells was sufficient to confer a solid immunity when tested 2 weeks after immunization. Fluid vaccine was fully potent after storage at 50⁰ C for 1 month. A good immunity was also obtained with live vaccines prepared from rough mutants of S. typhimurium. The degree of protection varied with the vaccine strain used. Only those mutants which possessed some degree of residual virulence produced a solid immunity while absolutely avirulent mutants were ineffective unless excessively high doses were employed. Neither inactivated nor live S. typhimurium vaccines conferred protection against S. dublin infection
Immunization of mice and guinea-pigs against Salmonella dublin infection with live and inactivated vaccine
Full text linkThe articles have been scanned in colour with a HP Scanjet 5590; 300dpi.
Adobe Acroabt XI was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.The immunogenicity of a number of avirulent rough Salmonella dublin mutants was compared in mice and guinea-pigs. Live vaccine prepared from Strain HB 1/17 at doses of 5 x 10⁷ per mouse usually gave an immunity of between 70 and 80% but in certain experiments the results were more variable and always poorer. This strain gave a cross protection of 28,5% to S. typhimurium in mice. In guinea-pigs it evoked an average protection of approximately 46% to homologous challenge and approximately 26% to challenge with S. typhimurium. Strain 5765 protected up to 80% of mice against S. Dublin infection and was generally superior to Strain HB 1/17 in this respect. It was, however, less effective in protecting mice against S. typhimurium (20%). In guinea-pigs it was also less effective than Strain HB 1/ 17, giving 34% protection against homologous and 20% against heterologous challenge. Other strains also produced immunity in mice but they were not studied in detail. Formalin-inactivated alum-precipitated vaccine prepared from avirulent smooth strain and containing 0, 5% packed cells proved to be extremely effective in protecting mice against S. dublin infection. It produced an average immunity of 75% and was often 100% effective. It also protected 60% of mice against challenge with S. typhimurium. In guinea-pigs it was, however, totally ineffective against challenge with both S. dublin and S. typhimurium
Sedimentation of bacteria with polyethylene glycol
Full text linkThe articles have been scanned in colour with a HP Scanjet 5590; 300dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Experiments are reported which show that the addition of 4,0% polyethylene glycol (6 000 MW) to liquid cultures of Clostridium welchii Type D , Pasteurella and Vibrio fetus (venerialis) will effectively sediment the bacteria. Live Brucella abortus S19, a smooth S. gallinarum Strain 28 600 and a formalin inactiviated suspension of V. fetus (intestinalis) Strain 661 were, however, not sedimented. When effective the method has appreciable application in the production of vaccines and other processes requiring the easy collection of large volumes of cells, and the separation of bacteria from their soluble exotoxins
The effect of immunosuppression on the development of immunity to fowl typhoid
Full text linkThe articles have been scanned in colour with a HP Scanjet 5590; 300dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Chickens which were given cyclophosphamide during the first three to five days of life showed a marked depression in their humoral antibody response to sheep erythrocytes and Brucella antigen. Their ability to develop tuberculin sensitivity and their immune response to live Salmonella gallinarum vaccine was, however, unimpaired. The administration of methylprednisoline acetate, hydrocortisone acetate, azathioprim and 6-mercaptopurine to either six or 10 to 12-week-old chickens neither selectively depressed the humoral or cellular immune response nor affected the immune response to live S. gallinarum vaccine. Similarly, the immune response could not be depressed by thymectomy or antilymphocyte globulin. These results indicate that immunity to S. gallinarum after administration of a live avirulent vaccine is not dependent on a humoral immune mechanism but probably primarily on cellular immunity, although this could not be proven
Inhibition of macrophage migration in Salmonella immunity
Full text linkThe articles have been scanned in colour with a HP Scanjet 5590; 300dpi.
Adobe Acroabt XI was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Protein antigens were prepared from rough strains of Salmonella typhimurium and S. dublin by
phenol and veronal-buffer extraction. It was shown that the in vitro migration of peritoneal exudate
cells from guinea pigs that were immunized with rough avirulent mutants could be inhibited
effectively with these antigens.
The cells obtained from S. typhimurium-immunized guinea pigs were also sensitive to S. dublin
antigens and vice versa.
A degree of sensitivity and inhibition could be demonstrated consistently in a group of
immunized guinea pigs. However, the variation in samples, even from among individual animals that
had survived challenge, was so great that it precludes the use of the macrophage migration technique
as a routine standard assay procedure for immunity
Effective immunization of lambs against enterotoxaemia
Full text linkThe articles have been scanned in colour with a HP Scanjet 5590; 300dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.In contrast to adult sheep, 2- to 3-month-old lambs do not respond well to a single injection of Clostridium perfringens Type D oil adjuvant epsilon toxoid. This unresponsiveness can be overcome, however, by administering 2 injections of oil adjuvant vaccine or one injection of oil adjuvant followed
4 weeks later by an injection of alum-precipitated toxoid. The latter procedure evokes protective antitoxin levels which persist for 8 months, and a booster injection of alum-precipitated toxoid given at this stage results in an immunity which lasts for at least 1 year
Effect of levamisole on immunity to Corynebacterium pseudotuberculosis in mice and sheep
Full text linkThe articles have been scanned in colour with a HP Scanjet 5590; 300dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.The stimulating effect of levamisole on immunity to Corynebacterium pseudotuberculosis in mice was marginal, while no enhancement of immunity could be detected in sheep. The conclusion was reached that, as levamisole has no potentiating effect on immunity to C. pseudotuberculosis in normal sheep, it is of no practical value as an immunostimulant in this instance
Comparative efficacy of six Brucella vaccines in guinea-pigs
Full text linkThis article has been scanned in colour with a HP Scanjet 5590; 300dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-Format.Immunity assays in guinea-pigs based on spleen mass: body mass ratios showed that live vaccines were markedly more effective than inactivated oil adjuvant vaccines in providing protection against challenge with 5 000 virulent organisms
Antibody response of guinea-pigs and cattle to a Campylobacter fetus oil emulsion vaccine
Full text linkThe articles have been scanned in colour with a HP Scanjet 5590; 600dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.A method is described for the mass production of Campylobacter fetus oil emulsion vaccine, using 2 strains of C. fetus ss intestinalis and a strain of C. fetus ss intermedius as a substitute for C. fetus ss venerialis. Heifers, given 2 injections of the vaccine, developed serum antibody titres comparable with the response induced by a commercial product
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