86,600 research outputs found
Analytical and Numerical Analysis on the Collapse Mode of Circular Masonry Arches
No full textIn this paper, an analytical and numerical analysis on the collapse mode of circular masonry arches is presented. Specific reference is made to the so-called Couplet-Heyman problem of finding the minimum thickness necessary for equilibrium of a masonry arch subjected to its own weight (Heyman 1977). The note reports the results of an on-going research project at the University of Bergamo. First, analytical solutions are derived in the spirit of limit analysis, according to the classical three Heyman hypotheses and explicitly obtained in terms of the unknown angular position of the intrados hinge at the haunch, the minimum thickness to radius ratio and the non-dimensional
horizontal thrust (Colasante 2007, Cocchetti et al. 2010). Results are then compared to Heyman solution. Though only the first of these three characteristics is perceptibly influenced in engineering
terms, especially at increasing opening angle of the arch, the treatment settles an important conceptual difference on the use of the true line of thrust, along the line of Milankovitch work. Second, numerical simulations by the Discrete Element Method (DEM) in a Discontinuous Deformation Analysis (DDA) computational environment are provided, to further support the validity of the obtained solutions, with good overall matching of the obtained results (Rusconi 2008, Rizzi et al. 2010)
dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice
No full textColasante et al. exploit an activatory CRISPR-targeting Scn1a gene promoter as a therapeutic strategy to rescue Scn1a haploinsufficiency in a mouse model of Dravet syndrome and restore physiological levels of its gene product, the Nav1.1 voltage-gated sodium channel
The invasive Stellaria media (L.) Vill.(Caryophyllaceae), a critical taxon at specific and subspecific level
No full textStellaria media variations and taxonomic problems at specific and subspecific leve
Causal agents of Fusarium head blight of durum wheat (Triticum durum Desf.) in central Italy and their in vitro biosynthesis of secondary metabolites
No full textDurum wheat samples harvested in central Italy (Umbria) were analyzed to: evaluate the occurrence of the fungal community in the grains, molecularly identify the Fusarium spp. which are part of the Fusarium head blight (FHB) complex and characterize the in vitro secondary metabolite profiles of a subset of Fusarium strains. The Fusarium genus was one of the main components of the durum wheat fungal community. The FHB complex was composed of eight species: Fusarium avenaceum (61%), F. graminearum (22%), F. poae (9%), F. culmorum (4%), F. proliferatum (2%), F. sporotrichioides (1%), F. sambucinum (0.5%) and F. langsethiae (0.5%). F. graminearum population was mainly composed of the 15-acetyldeoxynivalenol chemotype, while, F. culmorum population was composed of the 3-acetyldeoxynivalenol chemotype. In vitro characterization of secondary metabolite biosynthesis was conducted for a wide spectrum of substances, showing the mycotoxigenic potential of the species complex. F. avenaceum strains were characterized by high enniantin and moniliformin production. F. graminearum strains were in prevalence deoxynivalenol producers. F. poae strains were characterized by a high biosynthesis of beauvericin like the F. sporotrichioides strain which was also found to be a high T-2/HT-2 toxins producer. Production of aurofusarin, butenolide, gibepyrone D, fusarin C, apicidin was also reported for the analyzed strains
Self-love, growth, and competition in a public good game
No full textCompetition and cooperation are not always at odds and contributions to public goods are almost never one-off one-shot temporally isolated events. We examine voluntary contribution in a new public good experiment where "self-love" competitive motivations and time dynamic interdependencies are simultaneously considered. The competitive motivations are manipulated via subjects competing in each group (intragroup competition) for higher return factors on their public expenditure, whereas time dynamic interdependencies are modeled by letting returns from previous periods available for future contributions to public goods (CG). We ran two control conditions where intragroup competition (C) and time dynamic interdependencies (G) are separately implemented. Our findings showed that shares of endowment contributed were significantly greater and increasing over time when endowments growth and heterogeneous returns factors were simultaneously introduced. This effect can be attributed to return factors obtained in previous periods. Accordingly, wealth exponential growth has been greatly accelerated relative to our control condition. Distributive equity concerns have been also documented. Although Gini coefficients were significantly lower in the presence of heterogeneous return factors and endowments growth, inequality trends seemed to converge at control condition values in the long term
Italy’s functional ‘health federalism’ and dysfunctional cooperation
No full textAnalysis of the impact of the Covid-19 pandemic on the Italian regional system and of the performance of the different tiers of government in fighting the pandemi
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Preschoolers’ anticipation of sadness for excluded peers, sympathy, and prosocial behavior
No full textWe investigated the relations between anticipation of sadness for excluded peers, sympathy, and prosocial behavior in a sample of 127 Italian preschoolers (Mage= 4.84 years, SD = 0.85). Children attributed emotions to hypothetical excluded peers who exhibited withdrawn versus aggressive behavior, and these attributions were coded for the presence and intensity of sadness. Teachers rated children’s sympathy and prosocial behavior via questionnaire. In general, children attributed more sadness to the withdrawn excluded peer than the aggressive excluded peer. A path analysis revealed that those who anticipated higher levels of sadness for the withdrawn excluded peer were rated higher in sympathy and, in turn, higher in prosocial behavior. Attributing high levels of sadness to withdrawn excluded peers—who portray relatively heightened need—may be an early social-emotional characteristic of children who are more sympathetic and more likely to channel other-oriented concerns into prosocial actions
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