117,538 research outputs found
Design synthesis, in vitro biological evaluation and anti-biofilm activity of new beta-lactam and linezolid-like compound as potential antibacterial agents against Staphylococcus aureus infections in cystic fibrosis patients.
No full textProgetto interdisciplinare sulla progettazione e sintesi di nuovi antibiotici specifici per contrastare le infezioni da Staffilococco aureo in pazienti di fibrosi cistic
Terremoti e sanità. Considerazioni e proposte per il miglioramento della sicurezza sismica delle strutture ospedaliere
No full textThe Italian territory faces a high seismic risk. Moreover, the high vulnerability of health facilities increases the
danger for the population. This study departs from an analysis of the state of conservation of the national hospitals
and builds upon the data gathered on the recent earthquakes that have shaken Italy. Indeed, the study provides a
bulk of preventive measures directed to improve seismic safety of both the national health system and the hospitals
strategic value.
The focus is mainly centered on emergency management aspects and the maintenance of the functionality of the
medical services necessary to overcome the health crisis following an earthquake of high intensity.
The research is conducted considering how these issues were addressed in foreign countries. In particular, California
represents a central case study, since the high seismicity of the territory requires heavy investments to deal with the
seismic safety of the hospitals
Drug development of new beta-lactam and linezolid-like compounds active against Staphylococcus aureus isolated from cystic fibrosis patients: in vitro and in vivo biological evaluation
No full textIl progetto è volto alla progettazione e sintesi di nuovi agenti antibatterici a base beta-lattamica con attività duale antibiotica ed antiossidante capaci di agire efficacemente su ceppi di Staffilococco aureo meticillino resistente e sensibile provenienti da isolati clinici di pazienti di fibrosi cistic
Cost efficient master fabrication process on copper substrates
No full textIn this work a rapid and low cost process for master fabrication was carried out. Thick epoxy SU-8 photoresist was employed as sacrificial patternable layer for the definition of metal deposition area. An SU-8 photolithographic recipe was employed on low cost copper substrates, without the use of a seed layer. In particular an improvement of SU-8 adhesion, for structures with 7:1 aspect ratio, was obtained. This process was characterized by Field Emission Scanning Electron Microscope analysis on metallic substrates and it was compared with other UV-LIthographie Galvanoformung Abformung processes. An electrolytic Cu deposition was used to fabricate the master and, since the metal was deposited directly onto the copper substrate, the simplified LIGA-like process did not require silicon substrate removal or mechanical polishing. Hence, the fabrication steps and process time were considerably decreased. Finally, different molds with microfluidic patterns for hot embossing replication were obtained in 24 h with a significant costs reduction. © 2011 Elsevier B.V. All rights reserved
Lower IQ is associated with decreased clinical response to atomoxetine in children and adolescents with attention-deficit hyperactivity disorder
No full textAtomoxetine is commonly used to treat attention-deficit hyperactivity disorder (ADHD) in children with a broad range of cognitive abilities. We examined the association between level of cognitive functioning as determined by IQ and clinical response during treatment with atomoxetine
Design, synthesis, in vitro biological evaluation and anti-biofilm activity of new beta-lactam and linezolid-like compounds as potential antibacterial agents against Staphylococcus aureus infections in cystic fibrosis patients
No full textIn view of the widespread problem of antibiotic-resistance, innovative antibacterial strategies are required to improve the clinical outcome in CF infections. This project aims to develop new potential therapeutic alternatives for the treatment of respiratory staphylococcal infections in CF patients.
New anti-staphylococcal compounds, with beta-lactam or oxazolidinones-like structures, will be developed. The multidisciplinary approach of this project will involve the Unit of Milano isolating and characterising strains of S. aureus which will be used for screening libraries of compounds developed by the Bologna Unit during the first part of the project. Lead compounds will be optimized on the basis of antibacterial activity assessed by Milano-Bicocca Unit; lead compounds and their chemical modifications will be also be further analysed. Finally electron microscopy and cytotoxicity studies will also be carried out to determine their possible mechanism of action of the most promising compounds.
The goal of this research is the development of new lead compounds active against antibiotic-resistant strains of Staphylococcus aureus within the two years duration of the project
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