188,840 research outputs found
Cockcroft presentations
No full textAbstractLet p be a prime or 0. A presentation P (defining a group G) is said to be p-Cockcroft if the map π2(P) → H2(P, Zp) is 0 (where Z0 = Z). Moreover, if H is a subgroup of G then P is pH-Cockcroft if the covering of P (regarded as a 2-complex) corresponding to H is p-Cockcroft. These concepts, and other Cockcroft notions, are related to the minimality and efficiency of presentations, and to the “relation gap” problem (in particular, a finite presentation is efficient if and only if it is p-Cockcroft for some prime p). If P is p-Cockcroft then there exist minimal subgroups H of G for which P is pH-Cockcroft, called p-Cockcroft thresholds (these were introduced by Harlander and Gilbert — Howie when p = 0). We investigate these thresholds. Finally, we obtain necessary and sufficient conditions for the “natural” presentations for various group constructions ((generalized) graphs of groups, split extensions, direct products) to be p-Cockcroft. In particular, we see why it is difficult to find minimal presentations for direct products
Cockcroft properties of Thompson's group
No full textIn a study of the word problem for groups, R. J. Thompson considered a certain group F of self-homeomorphisms of the Cantor set and showed, among other things, that F is finitely presented. Using results of K. S. Brown and R. Geoghegan, M. N. Dyer showed that F is the fundamental group of a finite two-complex Z2 having Euler characteristic one and which is Cockcroft, in the sense that each map of the two-sphere into Z2 is homologically trivial. We show that no proper covering complex of Z2 is Cockcroft. A general result on Cockcroft properties implies that no proper regular covering complex of any finite two-complex with fundamental group F is Cockcroft.</p
An introduction to practice-based veterinary clinical research
No full textPeter D. Cockcroft and Mark A Holme
The Shetland Islands scrapie monitoring and control programme: Analysis of the clinical data collected from 772 scrapie suspects 1985-1997
No full textP.D. Cockcroft, A.M. Clar
Assessment of GFR by four methods in adults in Ashanti, Ghana : the need for an eGFR equation for lean African populations
No full textBackground. Equations for estimating glomerular filtration rate (GFR) have not been validated in Sub-Saharan African populations, and data on GFR are few.
Methods. GFR by creatinine clearance (Ccr) using 24-hour urine collections and estimated GFR (eGFR) using the four-variable Modification of Diet in Renal Disease (MDRD-4)[creatinine calibrated to isotope dilution mass spectrometry (IDMS) standard], Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Cockcroft–Gault equations were obtained in Ghanaians aged 40–75. The population comprised 1013 inhabitants in 12 villages; 944 provided a serum creatinine and two 24-hour urines. The mean weight was 54.4 kg; mean body mass index was 21.1 kg/m2.
Results. Mean GFR by Ccr was 84.1 ml/min/1.73m2; 86.8% of participants had a GFR of 60 ml/min/1.73m2. Mean MDRD-4 eGFR was 102.3 ml/min/1.73m2 (difference vs. Ccr, 18.2: 95% CI: 16.8–19.5); when the factor for black race was omitted, the value (mean 84.6 ml/min/1.73m2) was close to Ccr. Mean CKD-EPI eGFR was 103.1 ml/min/1.73m2, and 89.4 ml/min/1.73m2 when the factor for race was omitted. The Cockcroft–Gault equation underestimated GFR compared with Ccr by 9.4 ml/min/1.73m2 (CI: 8.3–10.6); particularly in older age groups. GFR by Ccr, and eGFR by MDRD-4, CKD-EPI and Cockcroft–Gault showed falls with age: MDRD-4 5.5, Ccr 7.7, CKD-EPI 8.8 and Cockcroft–Gault 11.0 ml/min/1.73m2/10 years. The percentage of individuals identified with CKD stages 3–5 depended on the method used: MDRD-4 1.6% (7.2 % without factor for black race; CKD-EPI 1.7% (4.7% without factor for black race), Ccr 13.2% and Cockcroft–Gault 21.0%.
Conclusions. Mean eGFR by both MDRD-4 and CKD-EPI was considerably higher than GFR by Ccr and Cockcroft–Gault, a difference that may be attributable to leanness. MDRD-4 appeared to underestimate the fall in GFR with age compared with the three other measurements; the fall with CKD-EPI without the adjustment for race was the closest to that of Ccr. An equation tailored specifically to the needs of the lean populations of Africa is urgently needed. For the present, the CKD-EPI equation without the adjustment for black race appears to be the most useful
The Cockcroft Institute Wakefields Interest Group
No full textThe Cockcroft Institute is a newly created international centre for Accelerator
Science and Technology in the UK. It is a joint venture between the Universities of
Lancaster, Liverpool and Manchester, and the Science and Technology Facilities
Council. The Cockcroft Institute has a large expertise base in Wakefields and
Impedances which is linked through the Cockcroft Institute Wakefields Interest Group.
Members of this group have experience in wakefields in linear colliders, ring colliders,
light sources as well as generic fundamental research and focus on a wide range of
specialist areas. In this article we summarize the work performed in this important field
of research at the Cockcroft Institute
Creatinine clearance versus serum creatinine as a risk factor in cardiac surgery
No full textWalter JA, Mortasawi A, Arnrich B, et al. Creatinine clearance versus serum creatinine as a risk factor in cardiac surgery. BMC Surgery. 2003;3(1): 4.BACKGROUND: Renal impairment is one of the predictors of mortality in cardiac surgery. Usually a binarized value of serum creatinine is used to assess the renal function in risk models. Creatinine clearance can be easily estimated by the Cockcroft and Gault equation from serum creatinine, gender, age and body weight. In this work we examine whether this estimation of the glomerular filtration rate can advantageously replace the serum creatinine in the EuroSCORE preoperative risk assessment. METHODS: In a group of 8138 patients out of a total of 11878 patients, who underwent cardiac surgery in our hospital between January 1996 and July 2002, the 18 standard EuroSCORE parameters could retrospectively be determined and logistic regression analysis performed. In all patients scored, creatinine clearance was calculated according to Cockcroft and Gault. The relationship between the predicted and observed 30-days mortality was evaluated in systematically selected intervals of creatinine clearance and significance values computed by employing Monte Carlo methods. Afterwards, risk scoring was performed using a continuous or a categorical value of creatinine clearance instead of serum creatinine. The predictive ability of several risk score models and the individual contribution of their predictor variables were studied using ROC curve analysis. RESULTS: The comparison between the expected and observed 30-days mortalities, which were determined in different intervals of creatinine clearance, revealed the best threshold value of 55 ml/min. A significantly higher 30-days mortality was observed below this threshold and vice versa (both with p < 0.001). The local adaptation of the EuroSCORE is better than the standard EuroSCORE and was further improved by replacing serum creatinine (SC) by creatinine clearance (CC). Differential ROC analysis revealed that CC is superior to SC in providing predictive power within the logistic regression. Variable rank comparison identified CC as the best single variable predictor, even better than the variable age, former number 1, and SC, previously number 9 in the standard set of EuroSCORE variables. CONCLUSION: The renal function is an important determinant of mortality in heart surgery. This risk factor is not well captured in the standard EuroSCORE risk evaluation system. Our study shows that creatinine clearance, calculated according to the Cockcroft and Gault equation, should be applied to estimate the preoperative renal function instead of serum creatinine. This predictor variable replacement gains a significant improvement in the predictive accuracy of the scoring model
eGFR (Cockcroft-Gault) of patients included in follow-up phase.
No full texteGFR (Cockcroft-Gault) of patients included in follow-up phase.</p
Cimetidine improves GFR-estimation by the Cockcroft and Gault formula
No full textIn some patients with renal disease 24-hour cimetidine aided creatinine clearances cannot equal GFR even after administration of the maximum daily dose of cimetidine. Short duration cimetidine aided creatinine clearances can equal GFR but are inconvenient for clinical use and can be inaccurate due to incomplete urine collection. We studied how accurately GFR can be estimated without the need to collect urine, by applying the Cockcroft and Gault formula (CCock) on a single plasma creatinine concentration, after oral administration of 3 x 800 mg cimetidine during the preceding 24 hours. GFR was measured as standard clearance, using continuous infusion of 125I-iothalamate. Nineteen patients with various renal diseases, plasma creatinine 40 ml/min/1.73 m2. Tubular creatinine secretion was blocked completely in 14 of them. With cimetidine both accuracy and precision of the Cockcroft clearance improved: the mean (+/- SD) ratio of CCock to GFR decreased from 1.28 (+/- 0.21) to 0.98 (+/- 0.11) (p < 0.001) and the standard deviation of the difference (CCock-GFR) decreased from 9.23 to 7.07 ml/min/1.73 m2 (p < 0.05). With cimetidine the Cockcroft clearance correlated well with GFR (r = 0.974, p < 0.001) and this was as good as the correlation, between GFR and a 4-hour standard creatinine clearance (r = 0.972, p < 0.001). In conclusion, with a minimum of inconvenience, this method provides the clinician with accurate information on GFR for the outpatient follow-up of patients with a mild-to-moderate decrease in renal function, provided that no gross discrepancy between total bodyweight and muscle mass is presen
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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