1,721,049 research outputs found
AN IMPROVED PROCEDURE FOR THE PREPARATION OF SUBSTITUTED THIAZOLES
No full textThe reaction between 3-amino-3-(dialkylamino)propenenitriles 1 and sodium thiocyanate in presence of bromine, provides an efficient route for the synthesis of 2-amino-5-cyano-4-(dialkylamino)thiazoles 3
Propenethioamides in the synthesis of heterocyclic systems. Synthesis of pyrrole and 1,4-thiazepine derivatives
No full textThe reaction of propenethioamides 1 with bromoketones 2 and 3 led in acidic medium to the formation of 1,4-thiazepines 6 and 7. The pyrrole derivatives 4 and 5 were obtained by reaction of 1 with 2 and 3 in basic medium
Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues
No full textA series of new 1,4-diarylimidazol-2(3H)-one derivatives and their 2-thione analogues has been prepared and evaluated
in vitro for antitumor activity against the NCI human cancer cell panel. Compounds bearing a 3,4,5-trimethoxyphenyl ring linked to
either N-1 or C-4 position of the imidazole core demonstrated an interesting profile of cytotoxicity with preferential activity against
leukemic cell lines. Compound 13 exhibited a potent antitumor activity against MOLT-4 (GI50 = 20 nM) and SR (GI50 = 32 nM)
cell lines
Synthetic potentialities of alkyl and aryl cyclopropylidenealkyl sulfides: Access to 1-(arylthio)vinylcyclopropanes by a 1,3-shift of an arylthio group
No full textAlkyl and aryl cyclopropylidenealkyl sulfides 2, 4 and 5 were converted to give access to 1-(arylthio)vinylcyclopropanes 3 by light induced or acid catalyzed 1,3-shift of the arylthio group. Some results on the reactivity of sulfides 2, 4 and 5 are reported
Simple synthesis of polyfunctional nitropyridines
No full textUpon treatment with nitroketene dithioacetal (2) in refluxing acetonitrile, enaminonitriles (1) afforded nitrodienamines (3). Polysubstituted nitropyridines (4 and 5) were obtained by cyclization of intermediates (3) with orthoformate and acetic anhydride respectively
17) Derivati propenetioamidici quali precursori sintetici di eterociclici biologicamente attivi
No full textNew potential imidazole-based antitumor agents. Synthesis and antiproliferative activity
No full textSynthesis and in vitro antitumoral activity of new N-phenyl-3-pyrrolecarbothioamides
No full textA new series of N-phenylpyrrolecarbothioamides were obtained from base catalyzed intramolecular cyclization of 3-amino-3-(alkyl or arylamino)propenethioamides. Pyrrole derivatives were evaluated for their in vitro anticancer activity toward cell lines of nine different types of human cancer. Some of newly prepared compounds demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10−6 M level and in some case at 10−8 M concentrations
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