1,552 research outputs found
Redemption in the work of Francis Stuart
No full textThe idea of redemption is central to an understanding of the work
of Francis Stuart. Through an examination of its development and
expression, it is possible to demonstrate the integrity of his work and
its distinctive qualities. Such a demonstration is necessary because
Stuart's writing has been subjected to comparatively little scholarly
inquiry, although reviews of his work, especially that produced since
1949, suggest that it is impressive and important.
First, a general background to Stuart's work, a discussion of the
special problems associated with reading it, and a summary of his corpus
is provided. This indicates that the idea of redemption is important to
his earliest writing. The state of redemption is shown to be a
necessary apotheosis for Stuart's outcast heroes; it involves spiritual
suffering through which may be found a sense of reintegration and a
higher reality. This is expressed through interrelated themes such as
those of gambler, artist and ordinary man; mystic and criminal; sacred
and profane love; and spirituality and the mundane. The nature of the
redemptive experience is further elaborated by distinctive, complex
motifs, especially the hare, the ark and the woman-Christ. Their
recurrence provides an important element in the unity of Stuart's work.
Because Stuart's idea of the outcast raises important biographical
questions, an examination of the relationship between Stuart's life and
his work is made. Finally, the way in which the idea of redemption
exists in the language structures of Stuart's novels is examined, with
especial reference to his most recent work, The High Consistory. The
thesis shows that the development of the these of redemption
demonstrates the integrity of Stuart's work
John Stuart Mill’s projected science of society: 1827-1848
No full textThe purpose of the thesis is to examine John Stuart Mill’s political thought from
about 1827 to 1848 as an exercise in intellectual history. It focuses, first, on Mill’s view,
formulated by the late 1830s, that contemporary society was ‘civilized’, and second, on
his project of a science of society, which he aspired to develop in the late 1830s and
early 1840s.
By the late 1830s, Mill came to the view that his contemporary society was a
‘commercial society or civilization’, dominated by the middle, commercial class. The
first part of my thesis, constituted by Chapters 2-4, discusses the way in which Mill
formed his notion of civilization, and what he meant by the term ‘civilization’. Mill paid
attention to the implications of the rise of the middle class, and regarded such
phenomena of contemporary society as the corruption of the commercial spirit and
excessive social conformity as an inevitable consequence of the rise of the middle class.
The second part of the thesis, constituted by Chapters 5-9, examines Mill’s
projected science of society. In the late 1830s and early 1840s, Mill attempted to
develop a new science of society whose subject-matter was the nature and prospects of
commercial, civilized society. This aspiration culminated in A System of Logic,
published in 1843. In examining Mill’s projected science, I pay particular attention to
the fact that he conceived new sciences of history and of the formation of character,
both of which were indispensable in his project, although he failed to give a complete
account of these sciences. My thesis shows that the implications of his interest both in
history and in the formation of character are more significant than Mill scholars have
assumed
Mrs. Sterling Hamlet with Jesse Stuart (on right), ca. 1958,
No full textMrs. Sterling Hamlet with Jesse Stuart (on right), ca. 1958, b&w. Note on back reads: L. Mrs. Sterling Hamlet (nee Theodosia Kirkland), past president, Women\u27 s Club of Huntington. R. Jesse Stuart (Author\u27s luncheon).https://mds.marshall.edu/doris_miller_papers/1106/thumbnail.jp
In the space behind his eyes : Donald R. Stuart : a biography
No full textThe major part of this thesis, In the Space Behind His Eyes, is a biography of Western Australian author, Donald Robert Stuart (1913-1983), a colourful life story woven around accepted and persistent myths found in the Australian psyche. In his childhood, Donald Stuart listened to stories about his Scottish immigrant grandfather finding gold on the Victorian fields and his father\u27s part in the 1891 Queensland Shearers strike. His poverty-stricken, but peaceful, upbringing in suburban Perth, Western Australia, was overtaken by the 1930s Depression and, as a rebellious fourteen-year old, he left home and took to the road. In the next decade or so, as he adopted the north-west outback life, he was exposed further to Australia\u27s traditional yarns and philosophies. He emerged from this period as the outrageous ‘Scorp’ Stuart, who drank too much and took advantage of the freedoms on offer. At the start of World War II, Scorp volunteered for the 2nd AlF. He served in the Middle East and somehow survived three-and-a-half years as a Prisoner of the Japanese, including a time on the infamous Burma-Thailand railway. On his return to Australia, he began to tread the writer\u27s path, supplementing his memories with renewed visits to the outback of his youth and working on yet another railway. Encouraged by his sister and her friends, supported by two of his wives and recognised by the Western Australian writh1g community, Donald R. Stuart played the role of noted author, a construct only possible because of Scorp Stuart\u27s adventures. Calling on these experiences, in eleven novels and many short stories, he set down his record of a particular Australian life. The varying facets of his complex character come together in his writing, notably through his deep love of the land and in his sympathetic examination of the north-west Aborigines\u27 position since white settlement. This biography of a writer sets out to trace the life of Donald Stuart, examine the disparity between Stuart the bushman and Stuart the noted author, and to shed light on the man behind the writing. In the essay following In the Space Behind His Eyes, I explore the biographical form, consider directions the genre has taken in recent years, discuss aspects of biography generally and support choices made in the writing of this biography
Scene thinking
No full textAn introduction is presented in which the author discusses several articles within the issue on topics including social research for scene thinking , genealogy development and Actor-Network Theory.Peer reviewedFinal article publishe
Going ... Going ... Gone
No full textPhotograph used for a story in the Daily Oklahoman newspaper. Caption: "Welch Long, 18, 412 NE first, watches sadly as R. C. Stuart, president of the Fidelity National bank, counts part of the $13500 taken in Oklahoma City's bank robbery Wednesday afternoon.
Towards a CRISPR-mediated therapy for Rett Syndrome
No full textRett syndrome (RTT) is a severe neurological disorder which is caused by
mutations in the X-linked gene MECP2 (methyl-CpG binding protein 2). RTT-like symptoms can be reversed in Mecp2-null mice by restoring MeCP2
expression, which suggests that the disorder may be curable. Based on this,
there has been a major focus on developing therapeutic strategies which can
restore MeCP2 levels. However, MeCP2 overexpression also leads to
neurological dysfunction, and so achieving safe but effective MeCP2 levels is
a significant challenge for conventional gene therapy approaches.
Most RTT-causing mutations affect two discrete domains which are necessary
and sufficient for MeCP2 function. However, some RTT-causing mutations
affect the region C-terminal to these domains. These include the missense
mutation P322L and a group of C-terminal deletions which account for
approximately 10% of RTT cases. These mutations cause RTT due to a
dramatic reduction in MeCP2 protein levels. Since mouse models lacking the
C-terminus of MeCP2 express normal levels of MeCP2 and do not have RTT-like symptoms, we hypothesised that removal of the mutant C-terminus would
restore MeCP2 protein levels and alleviate RTT-like symptoms.
This work investigates the potential of using CRISPR (clustered regularly
interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9)
to restore protein levels of P322L and the most prevalent C-terminal deletion.
Guide RNAs can be designed which target Cas9 to the mutant allele, where it
introduces a double-stranded break in the DNA. Since endogenous repair of
CRISPR/Cas9-induced lesions often generates frameshift-causing mutations,
we predicted that most repair products would generate stable C-terminally
truncated MeCP2. The advantages of this approach are that MECP2 remains
under the control of its regulatory elements, circumventing any issues with
gene dosage, and that cutting by transient expression of CRISPR/Cas9
components should provide permanent correction.
Using cell culture models I have demonstrated that CRISPR/Cas9 targeting of
P322L and a C-terminal deletion predominantly generates repair products with
increased protein levels. The stage is therefore set to determine whether
CRISPR/Cas9 targeting in vivo also increases MeCP2 protein levels in mouse
models of RTT, and whether this is sufficient to alleviate RTT-like symptoms.
The promising results in cell culture suggest that there is potential to translate
these findings into a therapy for RTT patients
The design of virtual environments
No full textVirtual reality (VR) is a highly interdisciplinary field involving computer science, perceptual psychology, human factors engineering, signal processing, and electrical, mechanical, and optical engineering. This unique book brings together vital information from all of these fields, providing both the theoretical and practical knowledge required to design VR systems capable of solving real-world problems. A serious treatment fo VR written specifically for engineers, researchers, and designers in industry and the military, this advanced-level handbook is up to date in every respect. Author and VR expert Rory Stuart describes each stage of the VR design process in detail, explaining a rigorous methodology for the planning, design, and testing of VR systems
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