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    Evidence for an altered dopamine beta-hydroxylase activity in migraine and tension-type headache

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    Sympathetic dysfunction is often present in migraine. It has been suggested that serum dopamine-beta-hydroxylase (D beta H) can be taken as an index of peripheral sympathetic activity. We studied the serum D beta H activity in migraine with and without aura and in tension-type headache patients compared with healthy control subjects. The serum D beta H activity was significantly lower in migraine and tension-type headache patients than in the control group. No significant difference was observed among the three groups of patients studied. These findings suggest that patients with migraine and tension-type headache have a sympathetic hypofunction that may play an important role in the pathogenesis.Sympathetic dysfunction is often present in migraine. It has been suggested that serum dopamine‐β‐hydroxylase (DβH) can be taken as an index of peripheral sympathetic activity. We studied the serum DβH activity in migraine with and without aura and in tension‐type headache patients compared with healthy control subjects. The serum DβH activity was significantly lower in migraine and tension‐type headache patients than in the control group. No significant difference was observed among the three groups of patients studied. These findings suggest that patients with migraine and tension‐type headache have a sympathetic hypofunction that may play an important role in the pathogenesis. 1992 Blackwell Munksgaar
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