8,314 research outputs found
Taylor_et_al._Supplementary_material – Supplemental material for Predictors of response to augmentation treatment in patients with treatment-resistant depression: A systematic review
No full textSupplemental material, Taylor_et_al._Supplementary_material for Predictors of response to augmentation treatment in patients with treatment-resistant depression: A systematic review by Rachael W Taylor, Lindsey Marwood, Ben Greer, Rebecca Strawbridge and Anthony J Cleare in Journal of Psychopharmacology</p
Is there a 'bipolar iceberg' in UK primary care psychological therapy services?
Get PDFBackground: Improving Access to Psychological Therapies (IAPT) is a primary care therapy service commissioned by England’s National Health Service (NHS) for people with unipolar depression and anxiety-related disorders. Its scope does not extend to ‘severe mental illness’, including bipolar disorders (BD), but evidence suggests there is a high BD prevalence in ostensibly unipolar major depressive disorder (uMDD) samples. This study aimed to indicate the prevalence and characteristics of people with BD in a naturalistic cohort of IAPT patients. Methods: 371 participants were assessed before initiating therapy. Participants were categorised by indicated diagnoses: BD type-I (BD-I) or type-II (BD-II) as defined using a DSM diagnostic interview, bipolar spectrum (BSp, not meeting diagnostic criteria but exceeding BD screening thresholds), lifetime uMDD or other. Information about psychiatric history and co-morbidities was examined, along with symptoms before and after therapy.Results: 10% of participants were grouped as having BD-I, 20% BD-II, 40% BSp, 25% uMDD and 5% other. BD and uMDD participants had similar demographic characteristics, but patients meeting criteria for BD-I/BD-II had more complex psychiatric presentations. All three ‘bipolar’ groups had particularly high rates of anxiety disorders. IAPT therapy receipt was comparable between groups, as was therapy response (F9,704=1.113, p=0.351). Conclusions: notwithstanding the possibility that bipolar diathesis was overestimated, findings illustrate a high prevalence of BD in groups of people notionally with uMDD or anxiety. As well as improving the detection of BD, further substantive investigation is required to establish whether individuals affected by BD should be eligible for primary care psychological intervention
sj-docx-1-jop-10.1177_02698811221104058 – Supplemental material for Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression
No full textSupplemental material, sj-docx-1-jop-10.1177_02698811221104058 for Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression by Fraser Scott, Elliot Hampsey, Sam Gnanapragasam, Ben Carter, Lindsey Marwood, Rachael W Taylor, Cansu Emre, Lora Korotkova, Jonatan Martín-Dombrowski, Anthony J Cleare, Allan H Young and Rebecca Strawbridge in Journal of Psychopharmacology</p
Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome
No full textObjective: Enhancement of negative feedback control of the HPA axis in patients with chronic fatigue syndrome (CFS) has been reported using the low dose dexamethasone suppression test. We have developed the use of prednisolone (5 mg) as a more physiologically appropriate alternative to dexamethasone in the investigation of mild degrees of glucocorticoid resistance or supersensitivity. The objective of the study was to use this test to look for alterations in negative feedback control of the HPA axis in CFS patients.Methods: Fifteen patients with CFS were recruited after fulfilling strict criteria including the absence of comorbid psychiatric diagnosis. They collected urine between 0900 and 1800 h and saliva at 0900 h pre-prednisolone. At midnight, they took prednisolone (5 mg) orally and then collected urine and saliva at the same intervals the following day.Results: Salivary cortisol was lower in CFS subjects pre-prednisolone than controls. Urinary cortisol metabolites were lower in CFS subjects pre-prednisolone, but did not reach significance. Both measures were significantly lower in CFS subjects post-dose. Mean percentage suppression of both salivary cortisol and urinary cortisol metabolites was significantly higher in CFS compared to controls.Conclusion: There is enhanced sensitivity of the HPA axis to negative feedback in CFS as demonstrated using the prednisolone suppression test. This provides further evidence of alterations in the control of the HPA axis in patients with established CFS
Interview with Anthony F. Janson
No full textAnthony F. Janson is a retired professor and former Department Chair for the UNCW Department of Art and Theatre [retired December 2002]. This interview covers his complete life and career. He discusses his relationship with his art historian father, H.W. Janson, including his relationship as son and co-author and editor of the Janson texts on art history. The interview covers Tony's career as a scholar, book editor, author, art museum curator [at Indianapolis Art Museum and North Carolina Art Museum], and as a professor. Throughout, he comments on important artists in history and his philosophy of art history. He also includes stories of his time in the Vietnam War
Interview with Anthony F. Janson
No full textAnthony F. Janson is a retired professor and former Department Chair for the UNCW Department of Art and Theatre [retired December 2002]. This interview covers his complete life and career. He discusses his relationship with his art historian father, H.W. Janson, including his relationship as son and co-author and editor of the Janson texts on art history. The interview covers Tony's career as a scholar, book editor, author, art museum curator [at Indianapolis Art Museum and North Carolina Art Museum], and as a professor. Throughout, he comments on important artists in history and his philosophy of art history. He also includes stories of his time in the Vietnam War
Assessment of subtle changes in glucocorticoid negative feedback using prednisolone: Comparison of salivary free cortisol and urinary cortisol metabolites as endpoints
No full textBackground
Prednisolone is better than dexamethasone to probe subtle changes in HPA axis sensitivity but cortisol assay as an endpoint risks cross-reaction with prednisolone. We compared capillary gas chromatography, which distinguishes urinary cortisol and prednisolone metabolites, and salivary cortisol immunoassay.Methods
Twenty adult volunteers (10 m) collected urine for consecutive 3 h periods and saliva at 3 h intervals from 2100 for 24 h, took prednisolone (5 mg) at midnight and continued collecting until 2100.Results
Suppression of urine cortisol metabolites began at 0600 and ceased after 1800. The lowest CV was obtained for the period 0900–1800: mean suppression was 56 ± 7% for males and 55 ± 9% for females. Suppression of salivary cortisol was only consistently seen at 0900: mean suppression was 41 ± 5% in males and 47 ± 9% in females. Chromatography revealed significant cross reactivity of prednisolone in saliva at 0300 and 0600, but not by 0900. Suppression of salivary cortisol and urinary cortisol metabolites was not correlated for either gender.Conclusion
Both urinary cortisol metabolite and salivary cortisol assay following administration of 5 mg prednisolone have potential for investigation of changed HPA axis negative feedback, based on a convenient pre- and post-dose urinary collection between 0900 and 1800 and salivary sampling at 0900
sj-docx-1-jop-10.1177_02698811221089042 – Supplemental material for Patient perspectives of lithium and quetiapine augmentation treatment in treatment-resistant depression: A qualitative assessment
No full textSupplemental material, sj-docx-1-jop-10.1177_02698811221089042 for Patient perspectives of lithium and quetiapine augmentation treatment in treatment-resistant depression: A qualitative assessment by Lucas McKeown, Rachael W Taylor, Elana Day, Rupal Shah, Lindsey Marwood, Helena Tee, Jess Kerr-Gaffney, Emanuella Oprea, John R Geddes, R Hamish McAllister-Williams, Allan H Young and Anthony J Cleare in Journal of Psychopharmacology</p
Letter from Anthony Brummelkamp to Mrs. G. Groen van Prinsterer
Get PDFIn a letter to Mrs. G. Groen van Prinsterer from Rev. Anthony Brummelkamp, the author is clearing up some statements of Rev. Budding and chiding Rev. Hendrik Scholte for having an arrogant and sharp tone. A foonote to the letter mentions the school operated by Rev. Brummelkamp and Rev. Albertus C. Van Raalte in Arnhem.https://digitalcommons.hope.edu/vrp_1840s/1193/thumbnail.jp
Fr. Anthony J. Gittins, C.S.Sp.
Get PDFFr. Anthony J. Gittins, C.S.Sp. [b. 1943] was ordained in 1967. He attended the University of Edinburgh from 1968-72 and received a doctorate in Social Anthropology in 1977. Fr. Gittins was a missionary to the Mende people in Sierra Leone from 1972-80. He went on to serve as a professor at the Missionary Institute and as Formation Director in London from 1980-84. He is the Emeritus Professor of Theology and Culture at the Catholic Theological Union in Chicago, Illinois, where he began teaching in 1984. Fr. Gittins has spent over thirty years ministering to homeless women and those leaving prostitution in Chicago, and is the author of several books.https://dsc.duq.edu/sohp/1000/thumbnail.jp
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