36 research outputs found
L’austro-nazionalismo dell’FPÖ e il processo di integrazione europea. La ricezione del “fenomeno Haider” nella stampa internazionale
No full textThe role of scrotal ultrasonography from infancy to puberty
No full textBackground: Scrotal ultrasonography is an essential diagnostic tool in daily clinical practice. The availability of new-generation ultrasound machines characterized by clearly improved image quality, low health cost, and higher patient safety, represents only some characteristics of ultrasound investigation. The usefulness of scrotal ultrasonography is particularly evident in the period of life from infancy to puberty, during which males undergo important morphofunctional changes, and several pathological conditions may occur. Objectives: This pictorial review primarily aimed to investigate the aspects of ultrasonography related to the normal physiological development of the gonads from mini-puberty to pubertal onset. This study also aimed to provide an update on the use of ultrasonography in main andrological pathologies that may occur during this period. The conditions that are discussed in depth are: cryptorchidism, inguinoscrotal hernias, and hydrocele in the neonatal phase; acute scrotum, epididymo-orchitis, and testicular cancers in childhood; and hypogonadism, varicoceles, testicular microlithiasis, and oncohematological pathology in puberty. Discussion: We provided an ultrasound slant for all the above-mentioned pathologies while purposely avoiding excessive deepening of the pathogenetic, clinical, and therapeutic aspects. Studying the ultrasound aspects of the gonads also facilitates differential diagnosis between various conditions and represents a good aid in evaluating therapeutic success (e.g., in hypogonadism or postsurgical evaluation of varicoceles and cryptorchidism). Conclusion: Scrotal ultrasonography is now globally recognized as the necessary completion of clinical–laboratory overview in gonads evaluation. This diagnostic procedure is even more indispensable in the infancy–childhood–puberty period for the evaluation of normal gonadal development as well as diagnosis of other possible diseases
3D printing of potassium sodium niobate by binder jetting: Printing parameters optimisation and correlation to final porosity
No full textBinder Jetting (BJT) is a non-fusion-based Additive Manufacturing (AM) technique. It consists of the selective deposition of a liquid binder to join powder particles, thereby enabling the creation of near-net-shaped parts. In this study, the main printing parameters correlated to the binder distribution and infiltration (binder saturation, binder set time, drying time, and target bed temperature) were optimised to improve the precision of green parts printed with potassium sodium niobate (KNN) powder. The optimisation procedure was conducted using the Taguchi statistical method. An L9 orthogonal array with four factors of control at three levels each was employed. The analysis showed that the drying time had the greatest influence on the precision of green parts, followed by binder saturation and target bed temperature. Binder set time did not seem to affect the results. Dimensional analysis, microstructural and piezoelectric characterisation of parts densified by pressureless sintering were conducted. The highest average relative density exceeded 80% for the specimens printed with the lower binder saturation. Piezoelectric properties exhibit more complex behaviour. The prolonged infiltration of larger binder volumes is correlated to higher g33, thus FOMh and FOM33, and lower values for ε33^T. On the other hand, d33 does not display a specific dependence on density or printing parameters. The results of this study indicate that BJT can be used to fabricate high-precision KNN components with good piezoelectric properties. The optimisation of printing parameters is essential to achieve the desired results.Binder Jetting (BJT) is a non-fusion-based Additive Manufacturing (AM) technique. It consists of the selective deposition of a liquid binder to join powder particles, thereby enabling the creation of near-net-shaped parts. In this study, the main printing parameters correlated to the binder distribution and infiltration (binder saturation, binder set time, drying time, and target bed temperature) were optimised to improve the precision of green parts printed with potassium sodium niobate (KNN) powder. The optimisation procedure was conducted using the Taguchi statistical method. An L9 orthogonal array with four factors of control at three levels each was employed. The analysis showed that the drying time had the greatest influence on the precision of green parts, followed by binder saturation and target bed temperature. Binder set time did not seem to affect the results. Dimensional analysis, microstructural and piezoelectric characterisation of parts densified by pressureless sinterin..
Il contributo italiano allo sviluppo del Cile
No full textUn volume che restituisce insieme attualità e prospettiva storica alla presenza della comunità di origine italiana in Cile, colmando una lacuna storiografica e proponendosi come essenziale contributo agli studi sull’argomento.- Indice #9- Presentazione #13- Emigrazione spontanea o assistita? Un vecchio dilemma riproposto dagli insediamenti agricoli italiani in Cile, Luigi Favero #17- Dalla riflessione alla pratica storiografica: itinerario e senso di una ricerca sugli italiani in Cile, Maria Rosaria Stabili #45- Profilo demografico dell’immigrazione italiana in Cile, René Salinas Meza #89- La partecipazione italiana all’industrializzazione del Cile. Origini ed evoluzione fino al 1930, Baldomero Estrada #103- L’immagine e il ricordo: storie di donne italiane in Cile, Paula Zaldivar H. #139- I marinai italiani in Cile a metà del secolo XIX, Valeria Maino #173- La presenza italiana nel ciclo del salnitro: Tarapacà, 1860-1900, Julio Pinto Vallejos #213- Missionari italiani in Araucania, 1600-1900. Evangelizzazione e rapporti interculturali, Jorge Pinto Rodriguez #243- L’integrazione degli immigrati italiani nell’economia della provincia di Concepción, 1890-1930, Leonardo Mazzei de Grazia #283- Gli italiani al confine dell’America: Patagonia australe e Terra del Fuoco, Mateo Martinić B. #317- Alcuni protagonisti italiani nel Cile del parlamentarismo, Claudio Rolle #349- L’emigrazione italiana in Cile: le fonti in Italia, Patrizia Salvetti #383- Cronologia #433- Glossario #443- Bibliografia #44
Simvastatin Treatment Highlights a New Role for the Isoprenoid/Cholesterol Biosynthetic Pathway in the Modulation of Emotional Reactivity and Cognitive Performance in Rats.
No full textThe aim of the present work was to shed light on the role played by the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and memory consolidation in rodents through the inhibition of the key and rate-limiting enzyme 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) both in vivo and in vitro with simvastatin. Three-month-old male Wistar rats treated for 21 days with simvastatin or vehicle were tested in the social interaction, elevated plus-maze, and inhibitory avoidance tasks; after behavioral testing, the amygdala, hippocampus, prefrontal cortex, dorsal and ventral striatum were dissected out for biochemical assays. In order to delve deeper into the molecular mechanisms underlying the observed effects, primary rat hippocampal neurons were used. Our results show that HMGR inhibition by simvastatin induces anxiogenic-like effects in the social interaction but not in the elevated plus maze test, and improves memory consolidation in the inhibitory avoidance task. These effects are accompanied by imbalances in the activity of specific prenylated proteins, Rab3 and RhoA, involved in neurotransmitter release and synaptic plasticity, respectively. Taken together, the present findings indicate that the isoprenoid/cholesterol biosynthetic pathway is critically involved in the physiological modulation of both emotional and cognitive processes in rodents.Neuropsychopharmacology accepted article preview online, 10 October 2013. doi:10.1038/npp.2013.284
Validation of ACR TI-RADS performance in transition age. Results from a multicenter retrospective study by the TALENT study group
No full textPurpose: Although thyroid nodules are less common in the pediatric population, the risk of malignancy is higher than in adult patients. The aim of this study was to evaluate the ultrasonographic predictive factors of malignancy in thyroid nodules and to validate American College of Radiologists (ACR) TI-RADS performance in transition age patients. Methods: One hundred forty-two patients aged between 14 and 21 years referred to the participating centers for FNA biopsy of a thyroid nodule between 2007 and 2022 were included and ultrasound reports and sonographic images were retrospectively analyzed. Nodule features were defined according to the ACR-TIRADS lexicon. Two reference standards were applied: FNA cytology and surgical histology. The diagnostic performance of single sonographic features was estimated. Significant predictors were then included in a multivariate regression model. Results: Nodules included in ACR-TIRADS categories TR4 or TR5 had 10-fold increased risk of indeterminate or suspicious/malignant cytology [p < 0.001]. In univariate analysis, solid composition [p = 0.016] and presence of hyperechoic foci [p = 0.040] significantly increased the likelihood of malignant histology. In multivariate regression analysis, irregular margins [p = 0.011] and hyperechoic foci [p = 0.019] were independent predictors of indeterminate or suspicious/malignant cytology. Conclusion: Nodules included in ACR-TIRADS categories TR4 or TR5 had 10-fold increased risk of indeterminate or suspicious/malignant cytology in transition age. ACR-TIRADS was not able to rule-out malignancy compared to FNAB alone, suggesting the need to reconsider recommendations in the transition age group
Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities
No full textJMJD6 is known to localize in the nucleus, exerting histone arginine demethylase and lysyl hydroxylase activities. A novel localization of JMJD6 in the extracellular matrix, resulting from its secretion as a soluble protein, was unveiled by a new anti-JMJD6 mAb called P4E11, which was developed to identify new targets in the stroma. Recombinant JMJD6 binds with collagen type I (Coll-I), and distinct JMJD6 peptides interfere with collagen fibrillogenesis, collagen-fibronectin interaction, and adhesion of human tumor cells to the collagen substrate. P4E11 and collagen binding to JMJD6 are mutually exclusive because the amino acid sequences of JMJD6 necessary for the interaction with Coll-I are part of the conformational epitope recognized by P4E11. In mice injected with mouse 4T1 breast carcinoma cells, treatment with P4E11 reduced fibrosis at the primary tumor and prevented lung metastases. Reduction of fibrosis has also been documented in human breast and ovarian tumors (MDA-MB-231 and IGROV1, respectively) xenotransplanted into immunodeficient mice treated with P4E11. In summary, this study uncovers a new localization and function for JMJD6 that is most likely independent from its canonical enzymatic activities, and demonstrates that JMJD6 can functionally interact with Coll-I. P4E11 mAb, inhibiting JMJD6/Coll-I interaction, represents a new opportunity to target fibrotic and tumor diseases
CO2 transoral microsurgery for supraglottic squamous cell carcinoma
No full textThe present study analyzed the results of the endoscopic approach to T1, T2 and selected T3 supraglottic carcinoma with the aim of reviewing functional and oncologic outcomes after different types of endoscopic supraglottic laryngectomies. This is a retrospective clinical study of 42 consecutive patients (mean age of 61.8 years, 33 males, 9 females) treated by the senior author for supraglottic squamous cell carcinoma with a transoral CO2 laser approach and reviewed from November 2010 to September 2017. Surgical procedures were classified according to the European Laryngological Society. In addition to the standardized transoral supraglottic laryngectomies, we introduced a modified type IVb by sparing the inferior third of the arytenoid if not directly involved in the tumor. Swallowing was evaluated with the Swallowing Performance Status Scale reported by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. Survival probabilities were estimated using Kaplan-Meier curves. Two type I, 2 type IIa, 2 type IIb, 3 type IIIa, 12 type IIIb, 13 type IVa, 3 type modified IVb, and 5 type IVb supraglottic laryngectomies were performed. Twenty-one patients (50%) underwent primary neck dissection. The pathologic TNM classification according to the 8th edition of the American Joint Committee on Cancer system was as follows: 9 pT1cN0, 2 pT1N0, 1 pT1N1, 7 pT2cN0, 1 rypT2cN0, 9 pT2N0, 4 pT2N1, 2 ypT2N1, 2 pT3cN0, 2 rypT3cN0, 1 pT3N1, and 2 pT3N2b. Mean follow-up was 3.4 years (range of 9 months to 6 years). According to the Kaplan–Meier analysis, 5-year disease-specific survival, local-relapse-free survival, nodal-relapse-free survival, overall laryngeal preservation and overall survival of patients without previous head and neck radiotherapy/open surgery were 100%, 95.2%, 87.8%, 100%, and 64.6%, respectively. Patients who underwent type I, IIa, and IIb resections (n = 6) started oral feeding the day after surgery, patients who underwent type III-IVb modified resections (n = 31) started oral feeding 3–4 days after surgery, and patients who underwent standard type 4b resections (n = 5) started oral feeding 7 days after surgery. Three months after surgery, patients without a clinical history of previous head and neck radiotherapy/open surgery who underwent type III, IVa, and modified IVb resections showed significantly better swallowing compared to patients who underwent standard type IVb resection: grade 4–6 impairment of swallowing in 8 and 66.7% of cases, respectively (p = 0.006072); patients with a clinical history of previous head and neck radiotherapy/open surgery who underwent type III, IVa, and modified IVb resections showed not statistically significant better swallowing compared to patients who underwent standard type IVb resection: grade 4–6 impairment of swallowing at 3 months in 16.7% and 50% of cases, respectively (p = 0.23568). Transoral CO2 laser supraglottic laryngectomy is an oncologic sound alternative to traditional open neck surgery and chemo-radiotherapy. Recovery of swallowing is significantly worsened after total resection of the arytenoid. Modified type IVb procedure leaving intact, when possible, the inferior third of the arytenoid and consequently the glottic competence, improves functional outcome
Hermeneutics and Epistemology
No full textIn a collection of essays published in the 1970s under the title Vernunft in die Zeitalter der Wissenschaft, Gadamer confronts developments in analytical epistemology, arguing about epistemology from a hermeneutical point of view. Relations between the two traditions remain difficult. Paolo Parrini was among the few who opened to a real dialogue, neither superficial nor formal. He considered the hermeneutical tradition from an epistemological point of view, finding many connections via a third view between metaphysical realism and strong relativism. This theoretically dense and challenging perspective was expressed in two essays – “Ermeneutica ed epistemologia” (1998) and “Ermeneutica ed epistemologia 2: Heidegger, Kant e la verità” (2011). Parrini focused on the concept of Offenheit der Erfahrung in Gadamer’s Wahrheit und Methode and, later, on Heidegger’s theory of truth as alètheia. In this paper the author argues that original results of Parrini’s research confirm the fruitfulness of the encounter between hermeneutics and epistemology. He tries at the same time to identify some friction points and theoretical constraints, for further comparative development, in theory of language and theory of history, on which Gadamer’s ontological hermeneutics lies. The first tends to eliminate any distance between experience and language; the second presents conflicting aspects about identity conditions of past events, as investigated in history. To become fully productive, the dialogue between epistemological and hermeneutical traditions will be able to face a deep revision about these topics.In a collection of essays published in the 1970s under the title Vernunft in die Zeitalter der Wissenschaft, Gadamer confronts developments in analytical epistemology, arguing about epistemology from a hermeneutical point of view. Relations between the two traditions remain difficult. Paolo Parrini was among the few who opened to a real dialogue, neither superficial nor formal. He considered the hermeneutical tradition from an epistemological point of view, finding many connections via a third view between metaphysical realism and strong relativism. This theoretically dense and challenging perspective was expressed in two essays – “Ermeneutica ed epistemologia” (1998) and “Ermeneutica ed epistemologia 2: Heidegger, Kant e la verità” (2011). Parrini focused on the concept of Offenheit der Erfahrung in Gadamer’s Wahrheit und Methode and, later, on Heidegger’s theory of truth as alètheia. In this paper the author argues that original results of Parrini’s research confirm the fruitfulness of the encounter between hermeneutics and epistemology. He tries at the same time to identify some friction points and theoretical constraints, for further comparative development, in theory of language and theory of history, on which Gadamer’s ontological hermeneutics lies. The first tends to eliminate any distance between experience and language; the second presents conflicting aspects about identity conditions of past events, as investigated in history. To become fully productive, the dialogue between epistemological and hermeneutical traditions will be able to face a deep revision about these topics
