57 research outputs found
Intra and post-operative bleeding and healing in patients using anticoagulant therapy: a large cohort study.
No full textThe efficacy and effectiveness induced by diode laser biostimulation on the rate of orthodontic tooth movement
No full textDebittering of Grape Juice by Electrospun Nylon Nanofibrous Membranes: Impact of Filtration on Physicochemical, Functional, and Sensory Properties
No full textThe effect of electrospun nylon-6 nanofibrous membranes (NFMs) on the concentration of bitter compounds and antioxidants of grapefruit juices during dead-end filtration processes was studied. Filtration experiments with aqueous standard solutions of different molecules showed that NFMs retain low molecular weight antioxidants (i.e., ascorbic and caffeic acids) only at early filtration stages, whereas they remove bitter glycosylated phenolics (i.e., naringin and narirutin) at a more stable ratio, variable according to the membrane thickness. Experiments with fresh grapefruit juice of two varieties (pink and yellow) showed that NFM-filtration reduces (17 to 30%) flavanones associated with the immediate bitterness and allows for the complete removal (>99.9%) of limonin, responsible for the persistent bitterness of many citrus juices. In contrast, the same process causes a lower loss of ascorbic acid (5%) and does not affect acidity, nor sugar concentration. The results confirmed that NFMs feature permselectivity towards bitterness-related compounds. This work highlights the NFM potential as filter devices for the selective reduction of the bitter terpenoid (limonin) and glycosylated flavonoids (naringin and narirutin) from grape juice citrus juices in the production of industrially-relevant beverages
Risk association between scleroderma disease characteristics, periodontitis, and tooth loss
No full textLymph-vascular Space Involvement and Outer One-third Myometrial Invasion Are Strong Predictors of Distant Haematogeneous Failures in Patients with Stage I-II Endometrioid-type Endometrial Cancer
No full textThe aim of this retrospective study was to assess the predictive value of different clinicopathological variables (patient age, tumour size, FIGO grade, myometrial invasion, lymph-vascular space involvement [LVSI], invasion margins, peri-tumour phlogistic infiltrate and mitotic activity) for the risk of distant haematogenous recurrences in patients with endometrioid-type stage Ib-II endometrial cancer. Between August 1990 and April 2005, 259 patients had undergone laparotomy, peritoneal washing, total abdominal hysterectomy and bilateral salpingo-oophorectomy, with or without pelvic +/- para-aortic lymphadenectomy for endometrioid-type endometrial cancer. Thirty-six (13.9%) patients had developed recurrent disease after a median time of 17 months (range, 2-128 months). The relapse had been locoregional in 9, distant in 21 and both locoregional plus distant in 6 cases. This study assessed 12 patients with FIGO stage Ib-II disease who had developed distant haematogenous recurrences and 20 randomly chosen control patients with FIGO stage Ib-II disease who had remained recurrence-free after a median follow-up of 52 months (range, 37-66 months). Adjuvant therapy had been: no further treatment in 15 patients, external pelvic irradiation in 14 patients, adjuvant external pelvic irradiation plus brachytherapy in 2 patients and platinum-based chemotherapy followed by external pelvic irradiation in I patient. The site of distant failure had been the lung in 9 patients, liver in 2 patients and lung plus liver in I patient. A concomitant locoregional relapse (vagina or lymph nodes) had occurred in 3 patients. The median interval between surgery and the development of distant failure had been 16.5 months (range, 5-113 months). On univariate analysis, a higher incidence of FIGO grade 3 (50% versus 10%, p=0.0114), outer one-third myometrial invasion (91.7% versus 35.0%, p=0.0051) and LVSI (75.0.% versus 20.0%, p=0.0022) was found in the patients who had developed distant haematogeneous metastases compared to the recurrence-free women. Multivariate analysis showed that LVSI (p=0.0264) and deep myometrial invasion (p=0.0345) were independent predictive variables for the risk of distant haematogeneous failure. Patients with these pathological findings should be enrolled in randomised trials designed to assess the role of adjuvant chemotherapy alone or combined with sequential and /or concomitant external pelvic irradiation
THE EMERGING OF A MULTILATERAL FORUM FOR DEBT RESTRUCTURING: THE PARIS CLUB
No full textThis paper describes the evolution of intergovernmental relationships on debt rescheduling. It starts describing some experiences that aroused in the 18th Century and which negotiations were carried out, in many occasions, with the help of gunboat diplomacy. The settlement of liabilities that were created at the aftermath of the two 20th Century World Wars, which were – at least for some countries –- not exactly debt but war reparations, gave some insights in how to deal with these problems allowing the debtor country to find its own path to get out of the debt overhang. The settlement of these foreign liabilities may give some guidelines for dealing with debt restructuring in more general cases The creation of the Paris Club – which is a very civilized way to settle debt defaults compared to gunboat diplomacy – is analyzed and described here: first its emergency as an ad hoc transitory institution and later its evolution toward its definitive establishment in the international financial system landscape. It is also suggested that for a combination of events, which included the launch in Evian of the G-8’s so-called Evian Approach for the Paris Club, as well as the lack of support of some major industrialized countries to the implementation of a Sovereign Debt Restructuring Mechanism (SDRM), the Paris Club has become the only feasible international intergovernmental debt restructuring mechanism in spite of numerous shortcomings embodied in it. On this basis, some improvements of the actual mechanism are proposed, without precluding the possibility of the implementation of a more equilibrated SDRM in the future.
Efectos de la agitación y resonancia de los sitios de atraque debido a la construcción del frente N°3, Puerto de Iquique
No full textEl Puerto de Iquique está situado en la Región de Tarapacá, Chile, su ubicación geográfica lo posiciona como una puerta natural de exportación e importación para productos manufacturados y materias primas, producidas en el Cono Central de Sudamérica hacia los mercados internacionales y viceversa. El año 2014 el recinto portuario transfirió 2.2 millones de toneladas y se proyecta hacia el año 2030 en un escenario conservador y otro favorable 5.5 y 7.0 millones de toneladas respectivamente, donde el 75% corresponderán a contenedores. Por lo anterior, la Empresa Portuaria de Iquique (en adelante EPI) proyecta la construcción de un nuevo terminal marítimo denominado Frente N°3 con capacidad de atender una nave tipo New Panamax.
Para verificar los efectos de la construcción del Frente N°3 en la agitación de oleaje y resonancia del recinto portuario se utilizó el modelo numérico MIKE 21 BW, desarrollado por Danish Hydraulic Institute (DHI) el cual está basado en las ecuaciones de BOUSSINESQ desarrolladas por Madsen et al. (1991) y modificadas por Madsen & Sɸrensen (1992). La herramienta fue validada de acuerdo a lo indicado en el instructivo SHOA, Pub. N°3201, empleando mediciones de campo para verano e invierno de 2015. Posteriormente el modelo se explotó para dos escenarios de SIMULACIÓN. El primero correspondió a la situación actual y el segundo a la construcción del Frente N°3, este último analizado para la denominada Alternativa 1 (tipología de escolleras de protección) y Alternativa 2 (tipología de cajones de hormigón armado). Se determinó que actualmente todos los sitios de atraque presentan excedencias de olas menores a 0.75 [m] y que para la construcción del Frente N°3, la Alternativa 1 genera mejores condiciones de agitación, donde las alturas no excederían los 0.30 [m] para todos los sitios de atraque.
Con relación a la resonancia se obtuvieron las frecuencias naturales de los sitios de atraque mediante la implementación de espectros sintéticos de ruido blanco (white noise). La metodología está contenida en el estado del arte (Giervelvse et al. (2001) y Koef-Hansen et al. (2005)) con lo cual se determinó que para la situación actual y escenario de expansión, los períodos de oscilación están contenidos entre 0.5 y 4 minutos. El modo de oscilación más bajo (Helmholtz) se encuentra asociado a una longitud de onda de 6780 [m], el cual provocaría un movimiento vertical de la superficie del agua de pocos centímetros. En general, los períodos que podrían hacer resonar el Puerto de Iquique se encuentran entre 33 y 81 [s] (0.030 a 0.0127 [Hz]), sin embargo se desconoce si forzantes de dichas características (grupos de ondas u ondas largas libres) se presentan en la zona de estudio ni la forma en que podrían ingresar al recinto portuario
P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcome
No full textAN OVERVIEW OF MAJOR SOURCES OF DATA AND ANALYSES RELATING TO PHYSICAL FUNDAMENTALS IN INTERNATIONAL COMMODITY MARKETS
No full textThe debate on whether price movements in commodity markets are determined by changes in physical supply and demand fundamentals or by the speculative effects of financial investors seems to find some element of agreement on one particular point: the need for increased transparency and improved information on futures markets and physical commodity markets. This discussion paper provides an assessment of the current situation with regard to availability of information on physical commodity markets, pointing to some of the existing information gaps and areas for improvement. The paper presents a comprehensive account of the different information sources for physical commodity markets (including their websites), and could therefore be considered a practical information tool in itself, of use to different stakeholders interested in knowing about developments in these markets.
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