195 research outputs found
Novel challenges in exploring peptide ligands and corresponding tissue-specific endothelial receptors
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New insights into cardiovascular and lipid metabolomics
No full textMetabolomics is the study of metabolite profiles in biological samples, particularly urine, saliva, blood plasma and fat biopsies. The metabolome is now considered by some to be the most predictive phenotype: consequently, the comprehensive and
quantitative study of metabolites is a desirable tool for diagnosing disease, identifying new therapeutic targets and enabling appropriate treatments. A wealth of information about metabolites has been accumulated with global profiling tools and several candidate technologies for metabolomic studies are now available. Many high-throughput metabolomics methodologies are currently under development and have yet to be applied in clinical practice on a routine basis. In the cardiovascular field, few recent metabolomic studies have been reported so far. This minireview provides an updated overview of alternative technical approaches for metabolomics studies and reviews initial applications of metabolomics that relate to both cardiovascular disease and lipid metabolism research
Role of fruits in the diet of small mustelids (Mustela sp.) from the western Italian Alps.
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Exploitation of food resources by the Eurasian badger (Meles meles) at the altitudinal limit of its Alpine range (NW Italy).
No full textBlast resistance of tuff stone masonry walls
No full textGas explosions frequently occur in residential buildings inducing the out-of-plane collapse of single structural components which may trigger the progressive collapse of the structure. In this study, the out-of-plane collapse capacity of load-bearing tuff stone masonry (TSM) walls subjected to blast loading is investigated. A finite element macro-modelling strategy was adopted and dynamic analysis was carried out through LS-DYNA software to derive pressure impulse diagrams for blast resistant design and assessment. Different modelling assumptions were considered. A sensitivity analysis allowed the evaluation of the influence of vertical pre-compression level and aspect ratio of TSM walls on blast collapse capacity. Numerical predictions of blast capacity were then compared to those provided by simplified analytical models, design code pressures and peak pressures estimated after real incidents
Altitudinal gradient of Eurasian otter (Lutra lutra) food niche in Mediterranean habitats
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