437 research outputs found
Phytochemical and Biological Studies of <i>Nepeta asterotricha</i> Rech. f. (Lamiaceae): Isolation of Nepetamoside
No full textThe n-butanolic extract, from an Iranian specimen of Nepeta asterotricha Rech. f. (NABE), displayed anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated J774A.1 macrophages, which reduced nitrites and cytokines production. Bioassay guided fractionation of the extract led to the isolation of four iridoid glycosides, including a new one known as nepetamoside (1), one hexenyl-diglycoside, and some polyphenol and flavonoid components. None of the isolated iridoid components displayed significant effects on nitrites formation in an in vitro LPS-induced model of inflammation, thus suggesting that the plant anti-inflammatory effect is probably due to a synergistic action among its constituents
THE NEWSPAPER “RECH" IN 1941-1944 AS A SOURCE OF THE RUSSIAN ORTHODOX CHURCH HISTORYDURING THE GREAT PATRIOTIC WAR
No full textThe article analyzes the materials on religious themes, published in the collaborationist newspaper “Rech” on the occupied territory in 1941-1944. The main focus is on the classification of publications (there were selected factual, idiomatic, comparative, anti-Semitic and historical articles) and their propaganda component. The author considers the qualitative and quantitative evolution of the newspaper materials on religious life. The conclusion is drawn on their scientific potential and connection with military operations and changes in the policy of the Soviet state. The analysis of the central line of comparison of religious life during the pre-revolutionary period, the Soviet period and during the occupation in all publications enables to reveal the methods of invaders’ propaganda activities. The consideration of other thematic lines and their literary features helps to present the ideological potential of the newspaper in the creation of the collaborationist movement, and to characterize “Rech” as the information source for the population of the occupied territories
Efeito do resveratrol complexado à hidroxipropil-β-ciclodextrina sobre parâmetros do estresse oxidativo em ratos normais e hiperglicêmicos
No full textMade available in DSpace on 2018-06-27T18:56:14Z (GMT). No. of bitstreams: 3
Claudia Grigolo Pinto.pdf: 1176064 bytes, checksum: 59a91895834e923c2658353b7e595164 (MD5)
Claudia Grigolo Pinto.pdf.txt: 107937 bytes, checksum: 1b0f8213d3d5c275ed204303dd4db6c4 (MD5)
Claudia Grigolo Pinto.pdf.jpg: 3006 bytes, checksum: 39d1ff3d9bf0d2f9de94bcb4adf42377 (MD5)
Previous issue date: 2014-03-31Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThe use of nanoparticles as carriers of drugs has been widely studied. These include cyclodextrins (CDs), cyclic oligosaccharides that allow the formation of inclusion complexes with lipohilic substances such as resveratrol (RSV). RSV is a polyphenol with antioxidant characteristics; when consumed, a great part is excreted, while the remainder is quickly metabolized in the body. The anti-inflammatory, antioxidant and preventive of metabolic diseased properties such as diabetes, stimulate the complexation of RSV to the hydroxypropyl-beta-cyclodextrin (HP-β-CD), thus enabling the increase of the bioavailability of an orally RSV. Hyperglycemia, a marker by which diabetes is diagnosed, promotes increased production of species reactive to oxygen by various routes that lead to cell damage and potentially to cell death. The oxidative stress parameters can be determined through certain techniques. The reduction in the amount or in the activity of endogenous antioxidant defenses is and indicative of oxidant injury and may, therefore, is considered as an excellent marker of oxidative stress. In this context, nanotechnology can contribute to the development of new therapeutic approaches for various diseases, including diabetes. The objective of this study is to investigate the in vivo effects of free and complex resveratrol to HP-β-CD on parameters of oxidative stress, based on the measurements of GSH, TBARS, total content of carbonyls, activity of SOD, CAT and GPx enzymes and determination of total protein in the cerebral cortex, liver, kidney and heart of normal and hyperglycemic rats. For this study, 70 male Wistar rats were used, form the vivarium of the Federal University of Santa Maria, randomly divided into five diabetic groups induced by streptozotocin (STZ), and five non-diabetic groups with seven animals per group. The hyperglycemic and normoglycemic groups daily received, through intragastric gavage, the following substances: water (control groups), free RSV in concentration of 1mg/kg (RSV groups), concentration of HP- β-CD equivalent to that present in complex (HP- β-CD groups), RSV complexed to the cyclodextrin at a concentration of 1 mg/kg body weight (complex groups) and a solution of 15% ethanol (ethanol group). After two months of treatment and 12 hours fasting, the animals were killed by decapitation. According to the data obtained, it was found that treatment with HP- β-CD caused a decrease of endogenous antioxidant molecules. When complexed to RSV, this decrease was lower; indicating a protective effect by RSV to the damage caused by the medium, in this case HP- β-CD. In the measurements of TBARS it was observed that there was a decrease in the RSV group and HP- β-CD, indicating a protective behavior to lipid peroxidation.O emprego de nanopartículas como carreadores de fármacos vem sendo vastamente estudado. Entre elas, estão as ciclodextrinas (CDs), que são oligossacarídeos cíclicos que permitem a formação de complexos de inclusão com substâncias lipofílicas, como o resveratrol (RSV). O RSV é um polifenol com características antioxidantes; quando consumido, há uma grande parte excretada, enquanto o restante é rapidamente metabolizado no organismo. As propriedades antioxidantes, anti-inflamatórias e preventivas de doenças metabólicas, como o diabetes, estimulam a complexação do RSV à hidróxi-propil-beta-ciclodextrina (HP--CD), possibilitando, dessa forma, o aumento da biodisponibilidade do RSV por via oral. A hiperglicemia, marcador por meio do qual se diagnostica o diabetes, promove aumento na produção de espécies reativas de oxigênio por diversas rotas, que levam a lesões celulares e potencialmente à morte celular. Os parâmetros de estresse oxidativo podem ser determinados através de diversas técnicas. A redução da quantidade ou da atividade das defesas antioxidantes endógenas é indicativa de lesão oxidante, podendo, portanto, ser considerada como excelente marcador de estresse oxidativo. Nesse contexto, a nanotecnologia pode contribuir para o desenvolvimento de novas abordagens terapêuticas para diversas doenças, entre elas o diabetes. O objetivo deste trabalho é investigar o efeito in vivo do resveratrol livre e complexado à HP-β-CD sobre parâmetros do estresse oxidativo, com base nas medidas de Glutationa reduzida (GSH), espécies reativas ao ácido tiobarbitúrico (TBARS), conteúdo total de carbonilas, atividade das enzimas superóxido dismutase (SOD), catalase (CAT), glutationa peroxidase (GPx) e dosagem de proteínas totais, no córtex cerebral, no fígado, nos rins e no coração de ratos normais e hiperglicêmicos. Para este trabalho, foram utilizados 70 ratos Wistar machos, provenientes do biotério da Universidade Federal de Santa Maria, separados aleatoriamente em cinco grupos diabéticos, induzidos por estreptozotocina (STZ) e cinco grupos não diabéticos, com sete animais por grupo. Os grupos normoglicêmicos e hiperglicêmicos receberam diariamente, por gavagem intragástrica, as seguintes substâncias: grupos controles receberam água, os grupos RSV receberam 1mg/kg de massa corporal, os grupos HP-β-CD receberam concentração de HP-β-CD equivalente àquela presente no complexo, os grupos complexo (RCD) receberam 1mg/kg e os grupos etanol (E) receberam solução de etanol a 15%. Os animais foram mortos, após dois meses de tratamento e com 12 horas em jejum, por decapitação, sem anestesia. De acordo com os dados obtidos, concluiu-se que o tratamento com HP-β-CD provocou uma queda das moléculas antioxidantes endógenas. Quando complexada ao RSV, tal queda foi menor, indicando uma proteção exercida pelo RSV ao dano causado pelo veículo, neste caso a HP-β-CD. Nas medidas de TBARS, observou-se que ocorreu uma queda nos grupos RSV e HP-β-CD o que indica um comportamento de proteção à lipoperoxidação
Unternehmergesellschaft (haftungsbeschränkt) im Vergleich zur englischen Limited Darstellung und kritische Betrachtung
No full textWirtschaft / Rech
Bagatellverstöße im Arbeitsverhältnis außerordentliche Kündigungsgründe für den Arbeitgeber sowie wirtschaftliche Schädigung der Unternehmen
No full textWirtschaft / Rech
Hydrogen-Methane Blend Storage in Depleted Reservoirs: An Option for Reusing Decommissioned Offshore Platforms
No full textThe paper presents an innovative approach to studying the reuse of a decommissioned natural gas production platform for the seasonal storage and extraction of a hydrogen-methane (H2-CH4) mixture from a depleted reservoir. The reuse plan involves removing outdated equipment from the platform’s decks while retaining essential components such as wellheads and separators. Exploiting a depleted reservoir for the injection of an H2-CH4 mixture requires a thorough understanding of its specific characteristics. This paper focuses on the engineering approach adopted in the basic design phase for such a conversion, providing recommendations and HSE guidelines. Given the hazardous nature of substances like hydrogen in the gas mixture, the paper also examines potential risk scenarios, particularly those involving containment loss. A qualitative and quantitative assessment of these risks is conducted to evaluate their impact on the structure and equipment. The results of this assessment serve as a foundation for later studies on layout optimization and domino effect prevention. Additionally, some critical scenarios are simulated using an innovative approach known as the Source Box Accident Model (SBAM), which was proposed in previous works. SBAM leverages Computational Fluid Dynamics (CFD) but decouples the accidental phenomenon into a release phase and a dispersion phase. This method overcomes the challenges conventional CFD tools face in assessing congested plant configurations, providing more precise estimations of gas cloud behavior. The simulation results indicate that the released gas remains within the platform deck domain, and the flammable cloud is significantly smaller than what traditional, simplified tools predict
Recent Trends and Perspectives on Defect-Oriented Testing
No full textElectronics employed in modern safety-critical systems require severe qualification during the manufacturing process and in the field, to prevent fault effects from manifesting themselves as critical failures during mission operations. Traditional fault models are not sufficient anymore to guarantee the required quality levels for chips utilized in mission-critical applications. The research community and industry have been investigating new test approaches such as device-aware test, cell-aware test, path-delay test, and even test methodologies based on the analysis of manufacturing data to move the scope from OPPM to OPPB. This special session presents four contributions, from academic researchers and industry professionals, to enable better chip quality. We present results on various activities towards this objective, including device-aware test, software-based self-test, and memory test.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Quantum & Computer EngineeringComputer Engineerin
Contraintes d'intégrité et transactions imbriquées
No full textPARIS-BIUSJ-Thèses (751052125) / SudocCentre Technique Livre Ens. Sup. (774682301) / SudocPARIS-BIUSJ-Mathématiques rech (751052111) / SudocSudocFranceF
Application of a new optimal operating strategy to a smart energy system in the de-regulated electricity market
No full textOver the last years, the electricity sector has drastically changed due to an increasing penetration of renewable energy sources (RES). RES have a stochastic nature that can be predicted with a limited accuracy. This brings new challenges for the optimal operation of energy systems fueled by RES. Some studies in the literature show that the intermittent nature of RES can be smoothed by a proper coupling between renewable and conventional production units, responsive demand, or energy storages.
In this study, an original optimal market offering strategy suggested by the first author is applied to an energy system fueled by both dispatchable and non-dispatchable renewable sources. The goal is to operate the system according to smart rules which allow the system to maximize profits (i.e. to operate it as a “smart energy system”). The system includes a photovoltaic system, two CHP internal combustion engines (bio-oil and bio-gas fueled), six woodchip boilers and both an electric and a thermal storage system. These units generate electricity and heat for a group of users having variable demands and trade electricity with the grid through a two-settlement electricity market (i.e. day-ahead and balancing). Market participation is of crucial importance, since the offers in the day-ahead market need to be submitted from 12 to 36 hours prior to real-time operation and influence the future optimal operation. Thus, all variables related to the operation of the “smart system” have been modeled as “recourse” decisions in the developed tool for optimal offers at the day-ahead stage.
The offering strategy is tested against a deterministic alternative in a case study. Results show how a full information on the stochastic processes can help exploit synergies between the heat and electric systems, yielding to lower expected operating costs
- …
