6,006 research outputs found
Clark Memorandum: Spring 1999
No full textWeightier Matters (Elder Dallin H. Oaks) The Constitutional Thought of J. Reuben Clark, Jr. (J. David Gowdy) A Courtroom with a View (Joyce Janetski) The Challenge (Alexander B. Morrison)https://digitalcommons.law.byu.edu/clarkmemorandum/1024/thumbnail.jp
Pachyonychis paradoxus H. Clark 1860
No full textPachyonychis paradoxus Clark 1860 (Figures 2, 3) Pachyonychus dimidiaticornis Dejean 1836:384 (nomen nudum) Pachyonychis paradoxus Clark 1860:63 + Plate II Fig. 7 (type locality: North America (Pennsylvania)) Hamletia dimidiaticornis Crotch 1873:59 (replacement name for Pachyonychis paradoxus Clark 1860). Mignot 1969:100 (synonymy). Material examined: Lectotype: 67.56; [illegible]; Pachyonychis paradoxus 163 Mels [pz.ac 3] Clark [illegible] dimidiaticornis Pensylvania Dg C 3p; Hamletia dimidiaticornis Crotch (1 syntype BMNH, male). Non-type material: 1 ♀: St. Simon Island, GA; 20-VII-1931, Quersfeld; Property of USNM; USNM 2037268; Pachyonychis paradoxus H. Clark det. A.S. Konstantinov, 2005 (USNM); 1♁: Mobile, ALA, H. P. Loding; male; Hamletia dimidiaticornis 15864 l.g.g. Cr.; Property of USNM (USNM); 1♁: Jacksonville Fla.; Coll Hubbard & Schwarz; Hamletia dimidiaticornis Cr.; Property of USNM (USNM); 1♀, dissected: Myrtle Beach, Horry Co. S. C., Apr. 22. 1919; ER Kalmbach Collector; Property of USNM; Hamletia dimidiaticornis Crotch det. H. F. Wickham (USNM). Distribution: USA — Alabama, Florida, Georgia, Maryland, North Carolina, New Jersey, Pennsylvania, South Carolina. (Riley et al. 2003, CSM personal data). Body size: length 4.1–4.9 mm, width 2.1–2.5 mm, illustrated specimen— 4.9 mm long. Description of female genitalia. Spermathecal pump clearly separated from receptacle, about two-thirds as long as receptacle, slightly arched, with top rounded. Apex of spermathecal pump flattened; length about one-third of spermathecal pump. Receptacle elongate, constricted at spermathecal pump, forming clear neck; maximum width situated at about one-third from basal part of pump, followed by slight constriction. Canal long, attached to base of receptacle, slightly widened at connection with duct, with two coils. Ramus widening near top, attached to canal via short bifurcation. Gland elongate. Posterior sclerotization of tignum broadly Y-shaped, much wider than midsection. Midsection of tignum nearly straight. Anterior sclerotization of tignum about as wide as midsection; apex blunt. Vaginal palpi shaped as conical funnels. Apex of vaginal palpus evenly rounded, facing anteromedially. Anterior sclerotization of vaginal palpus much wider than posterior sclerotization. Posterior sclerotization of vaginal palpi bearing multiple setae. Comments. The lectotype for Pachyonychis paradoxus Clark is designated here to fix the identity of this species.Published as part of Roie, Martijn Van, Clark, Shawn, Konstantinov, Alexander, Furth, David & Linzmeier, Adelita M., 2023, A paradox indeed: description of genitalia and clarification of the subtribal classification of Pachyonychis paradoxus Clark and Pachyonychus paradoxus Melsheimer (Coleoptera: Chrysomelidae: Galerucinae: Alticini), pp. 127-136 in Zootaxa 5227 (1) on pages 129-132, DOI: 10.11646/zootaxa.5227.1.6, http://zenodo.org/record/751846
Studies of the Newbury mining area
No full textThesis. (B.S.) Massachusetts Institute of Technology. Dept. of Geology and Geophysics, 1956.MIT copy bound with: A nuclear free precession magnetometer for prospecting / Alexander Richard Aitken. 1956.Bibliography: leaf 44.by Robert Bucknam Clark and Peter David Engels.B.S
Re-description of Chinese mitten crab Eriocheir sinensis H. Milne Edwards, 1853 (Crustacea: Brachyura: Grapsoidea: Varunidae) zoeal development using confocal laser scanning microscopy
No full textKamanli, Seyit A., Morritt, David, Ball, Alexander D., Goral, Tomasz, Clark, Paul F. (2018): Re-description of Chinese mitten crab Eriocheir sinensis H. Milne Edwards, 1853 (Crustacea: Brachyura: Grapsoidea: Varunidae) zoeal development using confocal laser scanning microscopy. Zootaxa 4507 (1): 1-67, DOI: https://doi.org/10.11646/zootaxa.4507.1.
Episode 4: Alexander Hamilton and the Newburgh Conspiracy
No full textThe Department of History’s Holly Baker sat down with Dr. David Head, historian, author, and lecturer of history at the University of Central Florida in Orlando, Florida. Dr. Head recently gave a talk at the 2017 Research Colloquium titled “Alexander Hamilton and the Newburgh Conspiracy: Military Politics at the Anxious End of the American Revolution”. In the interview with Holly, Dr. Head discusses conspiracy thinking and Alexander Hamilton’s role in the Newburgh affair.https://stars.library.ucf.edu/knightshistorycast/1003/thumbnail.jp
Alexander polynomial
No full textTitle: Alexander polynomial Author: Ľubica Jančová Department: Department of Algebra Supervisor: doc. RNDr. David Stanovský, Ph.D., Department of Algebra Abstract: The subject of interest of this thesis is the Alexander polynomial in the knot theory as a knot invariant and various methods of its computa- tion. The thesis focuses on the description of the computation of the Alexander polynomial using four different methods, namely: colouring regions of the knot diagram, colouring arcs of the knot diagram, Seifert's method and the method using the Conway polynomial. In the first chapter we introduce basic notions of the knot theory. In the following chapters we describe methods of computa- tion of the Alexander polynomial. The final chapter deals with the possibility of using the Conway polynomial to show that all of the mentioned methods result in the same polynomial. The main result of this thesis are proofs that might lead to the complete proof of equivalence of algorithms of computation of the Alexander polynomial. Keywords: knot theory, Alexander polynomial, knot invarian
Data from: An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic proarrhythmia mechanisms
No full textPlease cite as:
Alexander P. Clark, Siyu Wei, Darshan Kalola, Trine Krogh-Madsen, David J. Christini. (2022) Data from: An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic proarrhythmia mechanisms. [Dataset] Cornell University eCommons Repository. https://doi.org/10.7298/c883-s773Background and Purpose: Before advancing to clinical trials, new drugs are screened for their proarrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the misclassification of beneficial drugs as proarrhythmic.
Experimental Approach: An in silico-in vitro pipeline was developed to circumvent these shortcomings. A computational human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CMs) model was used as part of a genetic algorithm to design experiments, specifically electrophysiological voltage-clamp (VC) protocols, to identify which of several cardiac ion channels were blocked during in vitro drug studies. Such VC data, along with dynamically clamped action potentials (AP), were acquired from iPSC-CMs before and after treatment with a control solution or a low- (verapamil), intermediate- (cisapride), or high-risk (quinidine or quinine) drug.
Key Results: Significant AP prolongation (a proarrhythmia marker) was seen in response to both high-risk drugs. The VC protocol identified block of IKr (a source of arrhythmias) by all strong IKr blockers, including cisapride, quinidine, and quinine. The protocol also detected block of ICaL by verapamil and Ito by quinidine. Further demonstrating the power of the approach, the VC data uncovered a previously unidentified funny current (If) block by quinine, which was confirmed with experiments using a HEK-293 expression system and automated patch-clamp.
Conclusion and Implications: We developed an in silico-in vitro pipeline that simultaneously identifies proarrhythmia risk and mechanism of ion channel-blocking drugs. The approach offers a new tool for evaluating cardiotoxicity in the preclinical drug screening phase.Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number F31HL154655 (to A.C.) and U01HL136297 (to D.J.C.)
Evidence-based recommendations for the use of antiemetics in radiotherapy
No full textBackground and purposeTo report recommendations given in the Multinational Association of Supportive Care in Cancer (MASCC) International Consensus Conference regarding the use of antiemetics in radiotherapy.Patients and methodsA steering committee under MASCC auspice chose panel participants for the guidelines development process on prevention of chemotherapy- and radiotherapy-induced emesis (RIE). Pertinent information from published literature as of March 2004 was reviewed for the guideline process. Both the MASCC level of scientific confidence and level of consensus, and the American Society of Clinical Oncology (ASCO) type of evidence and grade for recommendation were adopted.ResultsTotal body irradiation is classified at high risk, upper abdomen at moderate, lower thorax, pelvis, cranium (radiosurgery) and craniospinal at low, head and neck, extremities, cranium and breast at minimal risk. The recommendations for the use of antiemetics in radiotherapy are as follows: prophylaxis with a 5-HT3 antagonist in patients at high and moderate risk levels of RIE (+/-dexamethasone in the former group), prophylaxis or rescue with a 5-HT3 antagonist in the low risk group, and rescue with dopamine or a 5-HT3 receptor antagonist in minimal risk level.ConclusionsThese recommendations represent a valid tool for prophylaxis and treatment of RIE in clinical practice.Ernesto Maranzano, Petra Ch. Feyer, Alexander Molassiotis, Romina Rossi, Rebecca A. Clark-Snow, Ian Olver, David Warr, Concetta Schiavone, Fausto Roil
FIGURE 53 in Re-description of Chinese mitten crab Eriocheir sinensis H. Milne Edwards, 1853 (Crustacea: Brachyura: Grapsoidea: Varunidae) zoeal development using confocal laser scanning microscopy
No full textFIGURE 53. An example measurement of dorsal, lateral and rostral spines using a ZI stage of Cancer magister (adapted from Shirley et al. 1987).Published as part of Kamanli, Seyit A., Morritt, David, Ball, Alexander D., Goral, Tomasz & Clark, Paul F., 2018, Re-description of Chinese mitten crab Eriocheir sinensis H. Milne Edwards, 1853 (Crustacea: Brachyura: Grapsoidea: Varunidae) zoeal development using confocal laser scanning microscopy, pp. 1-67 in Zootaxa 4507 (1) on page 65, DOI: 10.11646/zootaxa.4507.1.1, http://zenodo.org/record/371378
David Weinberger, expert on impact of technology on society
No full textIncludes descriptive metadata provided by producer in MP4 file: "Science and Technology - Videos - David Weinberger, expert on impact of technology on society."As part of our library lecture series, David Weinberger, author of The Cluetrain Manifesto and Everything is Miscellaneous: The Power of the New Digital Disorder, will speak on Monday, December 6 about how knowledge has changed in the networked age.Jean and Alexander Heard Librar
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