1,366 research outputs found
Open WIN Ambassadors: Call notes and documentation drafts
No full textCall notes, documentation and comms created by the Open WIN Ambassadors, Wellcome Centre for Integrative Neuroimaging, University of Oxford.
Please refer to the GitLab repository for most up-to-date materials and contributions: https://git.fmrib.ox.ac.uk/open-science/community/open-win-ambassadors
This version issued at the end of the 2021-2022 cohort.
Author Contributions (credit):
Conceptualization: Stuart Clare, Cassandra D. Gould van Praag, Clare E. Mackay.
Data curation: Cassandra D. Gould van Praag.
Formal analysis: Cassandra D. Gould van Praag.
Funding acquisition: Stuart Clare, Clare E. Mackay.
Investigation: Cassandra D. Gould van Praag.
Methodology: Stuart Clare, Cassandra D. Gould van Praag, Clare E. Mackay.
Project administration: Stuart Clare, Dejan Draschkow, Yingshi Feng, Cassandra Gould van Praag, Clare E. Mackay, Verena Sarrazin, Bernd Taschler.
Resources: Dejan Draschkow, Yingshi Feng, Cassandra Gould van Praag, Verena Sarrazin, Bernd Taschler.
Software: Dejan Draschkow, Yingshi Feng, Cassandra Gould van Praag, Verena Sarrazin, Bernd Taschler.
Supervision: Stuart Clare, Cassandra D. Gould van Praag, Clare E. Mackay.
Visualization: Dejan Draschkow, Yingshi Feng, Cassandra Gould van Praag, Verena Sarrazin, Bernd Taschler.
Writing - original draft: Dejan Draschkow, Yingshi Feng, Cassandra Gould van Praag, Verena Sarrazin, Bernd Taschler.
Writing - review & editing: Dejan Draschkow, Yingshi Feng, Cassandra Gould van Praag, Verena Sarrazin, Bernd Taschler
Detailed cloth-backed map of Clare Station
No full textDetailed cloth-backed map of Clare Station – Counties of Waljeers and Manara within the Western Land Division. No date known, thought to be mid 1880s. Details of vegetation, landscape and improvements with costing – houses, huts, fences, sheep yards, tanks. Homestead Leaseholder: Angus Nicholson Mackay (86-13 North Clare B, 10 240 acres). Proposed resumed area (North Clare and B/ Clare C.) Proposed leasehold (southern section of property)
Environmental change and skin cancer in Mackay
No full textThis paper aims to describe the incidence of skin cancer in Mackay to assess strategies aimed at reducing the incidence and to examine this problem using an ecological perspective
The future of pornography - panel debate. Speakers | Finn Mackay, Rowan Pelling, Peter Tatchell
No full textMany believe that porn's dark fantasies risk corrupting relationships and society. Has this arisen because pornography is largely created by men? Could feminist pornography featuring authentic sex, diverse bodies and female perspectives offer a truly liberating alternative? Or is porn fundamentally incompatible with intimacy and a problem for all of us until its abolished? Feminist thinker Finn Mackay, author of Belle de Jour: Diary of a London Call Girl Brooke Magnanti, human rights campaigner Peter Tatchell and Erotic Review editor Rowan Pelling imagine the future of pornography.In association with the New College of the Humanities
Duurzame energie: Een nuchter verhaal
No full textEen samenvatting van het boek 'Sustainable Energy - without the hot air' van David J.C. MacKay. Professor MacKay is hoogleraar aan de Universiteit van Cambridge en Chief Scientific Advisor to the Department of Energy and Climate Change van de Britse regering. In het boek vergelijkt hij het gebruik van energie met de hoeveelheid energie die opgewekt kan worden met duurzame energie.Delft Research Initiative
Risk and resilience in cognitive ageing
No full textWhilst advancing age is, on average, associated with declining cognitive abilities, the course of cognitive ageing is highly variable at the individual level. The overall aim of this thesis was to improve understanding of risk and protective factors associated with variability in cognitive ageing. I first explored the effect of Alzheimer’s risk gene ‘APOE’ on cognition in healthy adults, and by reviewing the extensive literature, I showed that APOE genotype can have diverse cognitive consequences via multiple neurobiological mechanisms, each with applications to distinct aspects of cognitive ageing and Alzheimer’s disease (AD). I also investigated subjective memory impairment (SMI), which like APOE is associated with increased AD risk, but is also commonly reported by healthy older adults. By presenting a clinical case of persistent SMI, and reviewing evidence for the long-term relevance of brain characteristics in SMI, I reported that MRI can detect early differences in brain structure that herald subsequent cognitive impairment, valuable in clinical settings to identify the most at-risk SMI cases. I also investigated protective factors that preserve cognitive ability in some older adults, particularly whether the brain supports this superior cognitive ageing in multiple ways, via some older adults maintaining more ‘youthful’ brains, and others harnessing additional functional resources to ‘adapt’ to the challenge of brain ageing. Using structural and functional brain metrics alone, I identified multiple patterns of brain ageing predicted to be associated with superior cognitive ageing, and compared cross-sectional and longitudinal cognitive performance, as well as multi-modal MRI metrics acquired at multiple time points between groups. Across these analyses, I found convergent evidence that maintenance of more ‘youthful’ brain structure and function is associated with prior and continued superior cognitive and brain outcomes, particularly in grey and white matter structure, so promotion of this brain profile should be a goal of interventions. High frontal resting- state connectivity in older adults with poorer brain structure was not associated with the predicted cognitive performance benefit, when compared to those with lower structural and functional brain characteristics. Overall, this thesis provides novel insights into risk and protective factors related to variability in cognitive ageing, upon which further use of sensitive cognitive and imaging measures, and unique populations such as the oldest-old, can expand to inform markers and interventions to maximise cognitive abilities in later life
WIN MR Protocol: Oxford Brain Health Centre (2019_102_BHC)
No full textProtocol for the acquisition of MRI data for the study "Oxford Brain Health Centre".
Conducted at the Wellcome Centre for Integrative Neuroimaging (WIN), University Oxford.
Please see the entry of this protocol in the WIN MR Protocols Database to ensure this is the latest version: https://open.win.ox.ac.uk/protocols/stable/6974395a-3745-4861-b8cc-1887e787d1c4
Author list and CRediT roles:
M Clare O’Donoghue (ORCID: 0000-0003-0819-2513) (Conceptualization; Data curation; Investigation; Methodology; Formal Analysis; Project Administration; Writing – original draft)
Jasmine Blane (ORCID: 0000-0002-3363-462X) (Data curation; Formal Analysis; Investigation; Project Administration; Writing – original draft)
Juliet Semple (ORCID: 0000-0001-5752-3572) (Methodology; Resources; Project administration; Writing – original draft)
Sebastian Rieger (ORCID: 0000-0001-5414-645X) (Methodology; Resources)
Nicola Aikin (Methodology; Resources)
Jon Campbell (ORCID: 0000-0003-4757-1655) (Methodology; Resources)
Pieter Pretorius (ORCID: 0000-0003-4929-6175) (Conceptualization; Methodology; Resources)
Ludovica Griffanti (ORCID: 0000-0002-0540-9353) (Conceptualization; Methodology; Software; Investigation; Formal Analysis)
Grace Gillis (ORCID: 0000-0002-6123-3647) (Data curation; Investigation; Formal Analysis)
Thomas Okell (ORCID: 0000-0001-8258-0659) (Methodology; Software)
Mark Chiew (ORCID: 0000-0001-6272-8783) (Methodology; Software)
Stephen Smith (ORCID: 0000-0001-8166-069X) (Conceptualization; Funding acquisition; Methodology; Software)
Karla L Miller (ORCID: 0000-0002-2511-3189) (Conceptualization; Funding acquisition; Methodology; Software)
Clare Mackay (ORCID: 0000-0001-6111-8318) (Conceptualization; Funding acquisition; Methodology; Supervision, Writing – review & editing)
Additional papers to be cited:
Melissa Clare O'Donoghue, Jasmine Blane, Grace Gillis, Robert Mitchell, Karen Lindsay, Juliet Semple, Pieter M Pretorius, Ludovica Griffanti, Jane Fossey, VanessaRaymont, Lola Martos, Clare E Mackay. The Oxford Brain Health Clinic: Protocol and Research Database. medRxiv 2022.05.26.22275565; doi:https://doi.org/10.1101/2022.05.26.22275565
Acknowledgments:
The development of this resource was funded by the NIHR Oxford Health Biomedical Research Centre, the NIHR Oxford Cognitive Health Clinical Research Facility, the Wellcome Centre for Integrative. The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z). The authors would also like to acknowledge support from Wellcome Trust Collaborative Award (215573/Z/19/Z). LG was supported by an Alzheimer’s Association (AARF-21-846366, PI: Griffanti). TO was supported by the Royal Academy of Engineering (RF/132) and a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 220204/Z/20/Z)
Politics of Feminist Revision in di Prima\u27s Loba
No full textIn her article Politics of Feminist Revision in di Prima\u27s Loba Polina Mackay explores Diane di Prima\u27s two-volume epic Loba (1998) and, through a comparison of di Prima to the work of Adrienne Rich, argues that Loba practices a politics of feminist revision. Further, Mackay examines the ways in which di Prima starts to move away from the recovery project of female voices in patriarchal culture, associated with late twentieth-century Feminism, towards a women\u27s literature which need not be defined entirely through its resistance to patriarchal narratives of gender in men\u27s literature. Here it focuses on di Prima\u27s revisionist critique of another epic by a modern female writer, H.D.\u27s Helen in Egypt (1961), where di Prima rewrites the mythical Helen into a single mother facing modern-day hardship. Mackay concludes that di Prima\u27s decision to appropriate H.D.\u27s Helen in Egypt is suggestive of the politics of feminist revision the author practices. It shows that, in addition to the rewrite of straightforwardly patriarchal narratives, such as the story of Mary in the Christian discourse, a fully revised script of female presence in literature and culture would also have to include a critique of women\u27s literature
Donepezil Enhances Frontal Functional Connectivity in Alzheimer's Disease: A Pilot Study
No full textBackground: We have previously shown that increased resting-state functional magnetic resonance imaging (fMRI)-based functional connectivity (FC) within the frontal resting-state networks in Alzheimer's disease (AD) patients reflects residual, possibly compensatory, function. This suggests that symptomatic treatments should aim to enhance FC specifically in these networks. Methods: 18 patients with probable AD underwent brain MRI and neuropsychological assessment at baseline and after 12 weeks of treatment with donepezil. We tested if changes in cognitive performance after treatment correlated with changes in FC in resting-state networks known to be altered in AD. Results: We found increases in FC in the orbitofrontal network that correlated with cognitive improvement after treatment. The increased FC was greatest in patients who responded most to treatment. Conclusion: This 'proof of concept' study suggests that changes in network-specific FC might be a biomarker of pharmacological intervention efficacy in AD
Dorothy Mackay: A Forgotten Female Pioneer in Archaeology
No full textIn 2022, the author of this paper came across four letters regarding epigraphic documentation of some elite tombs in the Theban necropolis, Egypt, written by Dorothy Mackay and addressed to Alan H. Gardiner, at the archive of the Griffith Institute, University of Oxford. The author of the letters was the wife of Ernest Mackay (1880–1943), a British archaeologist best known for his later work on the Indus Valley Civilisation, who was excavating on the Theban west bank between 1913 and 1916. However, as further investigation revealed, Dorothy, until recently an obscure figure, was an accomplished scholar in her own right, who worked together with her husband, acted as a curator of two museums, and published extensively in times when it was far from easy for women to obtain an education, let alone conduct research. Despite that, the only recent sources discussing Dorothy and her scholarly accomplishments lack some vital details on her life. The aim of this contribution is to provide some further information and context on Dorothy Mackay and her research in the first half of the twentieth century
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