3,167 research outputs found
Properties of the Collaborative Systems Metrics
Full text linkThe paper describes the key properties of the collaborative systems. There are presented main quality characteristics for the collaborative systems. The paper analyzes different types of indicators. They represent the base for further metrics definition. There are described the indicators most important characteristics as sensitivity, non catastrophic, non compensatory and representatives.collaborative system, metric
PROPERTIES OF THE COLLABORATIVE SYSTEMS METRICS
Full text linkThe paper describes the key properties of the collaborative systems. There are presented main quality characteristics for the collaborative systems. The paper analyzes different types of indicators. They represent the base for further metrics definition. There are described the indicators most important characteristics as sensitivity, non catastrophic, non compensatory and representatives.collaborative systems
Providence College Faculty Author Series 2012-2013: Dr. Adrian Weimer
Full text linkDr. Adrian Weimer (History, Providence College) discusses her new book Martyrs\u27 Mirror: Persecution and Holiness in Early New England and the cultural importance of martyrdom within Colonial America
Providence College Faculty Author Series 2012-2013: Dr. Adrian Weimer
No full textDr. Adrian Weimer (History, Providence College) discusses her new book Martyrs\u27 Mirror: Persecution and Holiness in Early New England and the cultural importance of martyrdom within Colonial America
Adrian Matejka, 34th Annual ODU Literary Festival
No full textAdrian Matejka is the author of The Devil’s Garden and Mixology, which was a winner of the 2008 National Poetry Series. He is the recipient of two Illinois Arts Council Literary Awards and fellowships from Cave Canem and the Lannan Foundation. His work has been featured in American Poetry Review, The Best American Poetry 2010, and Ploughshares, among other journals and anthologies. He teaches at Southern Illinois University Edwardsville
Patients with ankylosing spondylitis present a distinct CD8 T cell subset with osteogenic and cytotoxic potential.
Full text linkOBJECTIVES
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease affecting mainly the axial skeleton. Peripheral involvement (arthritis, enthesitis and dactylitis) and extra-musculoskeletal manifestations, including uveitis, psoriasis and bowel inflammation, occur in a relevant proportion of patients. AS is responsible for chronic and severe back pain caused by local inflammation that can lead to osteoproliferation and ultimately spinal fusion. The association of AS with the human leucocyte antigen-B27 gene, together with elevated levels of chemokines, CCL17 and CCL22, in the sera of patients with AS, led us to study the role of CCR4+ T cells in the disease pathogenesis.
METHODS
CD8+CCR4+ T cells isolated from the blood of patients with AS (n=76) or healthy donors were analysed by multiparameter flow cytometry, and gene expression was evaluated by RNA sequencing. Patients with AS were stratified according to the therapeutic regimen and current disease score.
RESULTS
CD8+CCR4+ T cells display a distinct effector phenotype and upregulate the inflammatory chemokine receptors CCR1, CCR5, CX3CR1 and L-selectin CD62L, indicating an altered migration ability. CD8+CCR4+ T cells expressing CX3CR1 present an enhanced cytotoxic profile, expressing both perforin and granzyme B. RNA-sequencing pathway analysis revealed that CD8+CCR4+ T cells from patients with active disease significantly upregulate genes promoting osteogenesis, a core process in AS pathogenesis.
CONCLUSIONS
Our results shed light on a new molecular mechanism by which T cells may selectively migrate to inflammatory loci, promote new bone formation and contribute to the pathological ossification process observed in AS
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study
Full text linkBACKGROUND The link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated.
OBJECTIVES The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients.
METHODS The effects of different concentrations of glucose and fructose (1000 mg%, 500 mg%, 250 mg% and 100 mg% w/v) on the growth rate of CA have been studied by flow-cytometry.
FINDINGS We found that glucose concentration is directly related to CA growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients; we also show that fructose inhibits CA growth rate.
MAIN CONCLUSIONS As a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites
Mobile Learning Applications Audit
Full text linkWhile mobile learning (m-learning) applications have proven their value in educational activities, there is a need to measure their reliability, accessibility and further more their trustworthiness. Mobile devices are far more vulnerable then classic computers and present inconvenient interfaces due to their size, hardware limitations and their mobile connectivity. Mobile learning applications should be audited to determine if they should be trusted or not, while multimedia contents like automatic speech recognition (ASR) can improve their accessibility. This article will start with a brief introduction on m-learning applications, then it will present the audit process for m-learning applications, it will iterate their specific security threats, it will define the ASR process, and it will elaborate how ASR can enhance accessibility of these types of applications.IT Audit, Software Testing, Penetration Testing, Mobile Applications, Multimedia, Automatic Speech Recognition
Performing the archive: following in the footsteps
Full text linkUsing documentation of Mike Pearson's performance 'Bubbling Tom', Deirdre Heddon attempts to step into his shoes and re-perform it
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