19 research outputs found
Frequency of sister chromatid exchanges in the lymphocytes of patients with atopic dermatitis
No full textThe combination of genetic susceptibility and environmental factors can induce allergic sensitization and subsequent local inflammation, resulting in atopic dermatitis (AD). Sister chromatid exchange (SCE) is a sensitive method that may reflect an instability in DNA or a deficiency in DNA repair. The aim of the present study was to investigate whether patients with AD have defects in DNA repair and whether SCE frequency can be used as a genetic marker in the pathogenesis of AD. Between September 2004 and July 2005, SCE was analyzed in the peripheral blood lymphocyte chromosomes of 32 patients with AD and 28 control subjects at the Dermatology Unit of Erzurum State Hospital. This study found that the SCE frequency was significantly increased in patients with AD (P < 0.00001). The prevalence of SCE was not correlated with patient age, sex, disease duration or AD disease severity. Our results indicate that increased chromosome instability may play an important role in the etiology of AD
Is confluent and reticulated papillomatosis without papillomatosis early or late stage of confluent and reticulated papillomatosis?
No full textThe histologic findings of confluent and reticulated papillomatosis include papillomatosis, hyperkeratosis, and minimal or no acanthosis. We present a patient with the clinical findings of confluent and reticulated papillomatosis who responded dramatically to azithromycin, but histologic examination did not reveal papillomatosis. We observed invagination of basket-weave hyperkeratosis through the epidermis. We considered this finding may give a clue for the diagnosis of confluent and reticulated papillomatosis
A case of early onset confluent and reticulated papillomatosis with an unusual localization
No full textConfluent and reticulated papillomatosis is a relatively rare dermatosis of unknown origin. It is characterized by papules that become confluent in the center and reticulated at the periphery. The sites of predilection are the neck, interscapular region, inframammary area and abdomen. In a 15-year-old girl diagnosed with confluent and reticulated papillomatosis, the lesions first appeared on her knees and elbows when she was 4-years-old, and on the interscapular area when she was 13. Similar lesions arose on the left hand a few weeks previous to her visit. Two biopsy specimens were taken from the interscapular and elbow areas. The histopathological findings of this case fit the diagnosis of confluent and reticulated papillomatosis. We expect good results from azithromycin therapy
Purpuric pityriasis rosea
Get PDFPityriasis rosea (PR) is a common self-limited exanthem of unknown
cause. The typical presentation of PR is easily recognized. Since
purpuric PR is a very rarely seen variant, its diagnosis is sometimes
difficult. In our 16-year-old female patient, maculopapular eruptions
were healed spontaneously after one month. Erythrocyte extravasation in
the dermis was observed in the histopathologic examination
Purpuric pityriasis rosea
No full textPityriasis rosea (PR) is a common self-limited exanthem of unknown
cause. The typical presentation of PR is easily recognized. Since
purpuric PR is a very rarely seen variant, its diagnosis is sometimes
difficult. In our 16-year-old female patient, maculopapular eruptions
were healed spontaneously after one month. Erythrocyte extravasation in
the dermis was observed in the histopathologic examination
Comedonal, cornifying and hypertrophic Darier's disease in the same patient: A Darier combination
No full textOur 42-year-old patient had comedonal Darier's disease (DD) on the face, comedonal cornifying DD on the upper back, and hypertrophic DD on both legs. Biopsies taken from face, upper back and medial sides of the legs were found to be compatible with these clinical subtypes. The comedonal type was in the classical place, but the hypertrophic and cornifying types were not in the usual sites. In addition to the classic histopathology of DD, we noted multiple, warty dyskeratoma-like structures in the comedonal type, marked compact hyperkeratosis in the cornifying type, and marked papillomatosis in the hypertrophic type
