1,721,406 research outputs found
Metamucil as an additional source of dietary fiber: impact of the quality of healthcare professionals' recommendations on users' experience
No full textMetamucil® is a fiber supplementation formed by 100% natural psyllium. This study, conducted in Italy, assessed the impact of quality of pharmacists' instruction to use this product on subjects' adherence to and overall satisfaction with this test product
Nutraceuticals with clinically detectable blood pressure lowering effect: a review of available randomized clinical trials and their meta-analyses
No full textAIM:
To review and comment the available evidence on nutraceuticals with clinically demonstrated blood pressure (BP) lowering effect.
METHODS:
We reviewed studies published in English language from 1990 to 2015 on dietary supplements or nutraceuticals claiming to show an effect on human BP. An initial list of possibly effective agents and studies was obtained from the online reference Natural Medicine Comprehensive Database. Using PubMed, we searched agents identified from this list and the MeSH terms "hypertension", "blood pressure", "dietary supplement", and "nutraceuticals" alone and in combination. Then we focused our attention on meta-analyses and randomized clinical trials (RCTs).
RESULTS:
Beyond the well-known effects on BP of the DASH (Dietary Approaches to Stop Hypertension) and the Mediterranean diets, a large number of studies has investigated the possible BP lowering effect of different dietary supplements and nutraceuticals, the most part of them being antioxidant agents with a high tolerability and safety profile. In particular, a relatively large body of evidence supports the use of potassium, magnesium, L-arginine, vitamin C, cocoa flavonoids, beetroot juice, coenzyme Q10, controlled-release melatonin, and aged garlic extract. The antihypertensive effect of all these nutraceuticals seems to be dose-related and the tolerability is overall good.
CONCLUSION:
Some nutraceuticals could have a positive impact on BP in humans. Further, clinical research is advisable to identify between the available active nutraceuticals those with the best cost-effectiveness and risk-benefit ratio for a large and long-term use in general population with low-added cardiovascular risk related to uncomplicated hypertension
Dietary Practices
No full textFrom the era of the ‘fathers’ of medicine, like Aesculapius, a
large attention has been given to a correct diet as the best way
to maintain health. During the last century, we have sampled
many data on diets or specific diet components that could have
positive or deleterious effects on health. Nevertheless, what
kinds of data are available
Dislipidemia e coronaropatia.
No full textEpidemiologia della malattia coronarica e possibilità di intervento terapeutico
Ruolo di lacidipina nel paziente iperteso
No full textReview delle evidenze cliniche di efficacia preventiva del farmaco lacidipina nel paziente ipertes
Approccio mutraceutico alla ipertensione arteriosa
No full textRuolo della nutrizione, alimentazione funzionale ed integrazione alimentare sui valori della pressione arteriosa ed implicazioni cliniche
Inner ear symptoms: can we use them to approach cardiovascular diseases?
No full textSensory organs are programmed to detect external stimuli, and inform about possible threats. In general, they are characterized by a complex architecture, a highly energy-requiring function, a peripheral location and a vascular supply depending on a terminal circulation usually under systemic control. Their function may be highly sensitive to more general disorders primarily involving other organs or physiological systems. Consequently, the onset of transient or persistent symptoms of impairment of sensory organs might be the expression of abnormalities in the integrity of more general systems, especially in the elderly population. In the otologic area, despite the availability of evidence supporting the negative impact of some systemic conditions negatively affecting the local blood supply at the labyrinth level, the possibility that the inner ear can reveal the presence of sub-clinical, non-otologic disorders has never been the topic of a constructive investigation. The present review summarizes the preliminary available evidence suggesting a possible negative impact of early systemic hemodynamic changes on the function of the inner ear, as well as the possibility that some audiological symptoms may play some role in the early detection of cardiovascular diseases. In particular, we hypothesize that some cardiovascular diseases may cause an impairment in correct labyrinthine function as a result of a negative interaction between systemic hemodynamic changes, a reflex activation of the autonomic nervous system, and a local vascular response. A multidisciplinary approach to the interpretation of inner ear disorders may increase the possibility of an earlier recognition and understanding of systemic dysfunctions in clinical practice
Serum Uric Acid and Cardiometabolic Disease: Another Brick in the Wall?
No full textno abstract availabl
Inflammatory Modulation by Statins and Heart Failure
No full textHeart failure (HF) results from a variety of processes leading to deregulation and damage of cellular and interstitial components of the heart, such as endothelial cells, myocytes, fibroblasts, conduction system fibers, extracellular matrix, and structural interstitial proteins. In vitro and ex-vivo studies as well as observational studies support a possible preventive role of statins in HF prevention and evolution, while clinical data are more contrasting. In this chapter, we will summarize the evidence for the regulatory effects of statins on cellular pathways possibly implicated in HF, approaching, in particular, inflammation and the functions of immune cells, endothelial cells, fibroblasts, and cardiomyocytes. Then, we will shortly evaluate how this vast preclinical data relate to the clinical evidence of statin efficacy in HF patients
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