1,721,109 research outputs found
safety and impact on diagnostic accuracy of early analgesia in suspected acute appendicitis: A meta-analysis
No full textLaparoscopic versus open appendectomy in obese patients: A meta-analysis of prospective and retrospective studies
No full textBackground: A meta-analysis of different kinds of studies was performed to assess outcomes of laparoscopic versus open appendectomy in obese patients. Materials and Methods: Retrospective and prospective studies enrolling patients with a body mass index greater than 30 kg/m 2 were included. Primary outcomes were days of hospital stay, surgical procedure duration, and overall post-operative complication rate. Secondary outcomes were wound infection and intra-abdominal abscesses formation rate, hospital charges. Results: Laparoscopic appendectomy showed to be significantly associated with lower wound infection (P < 0.001) and post-operative complication rate (P < 0.001). Surgical time was considered as a hallmark of technical challenge and resulted diminished in the laparoscopic group (P = 0.018). Although not clinically relevant per se, the statistically significant shorter hospital stay (P < 0.001) was probably the reason of decreased hospital charges (P < 0.001). Intra-abdominal abscesses formation rate was higher in the open appendectomy group (P = 0.058), although slightly above the statistical significance threshold. Conclusion: Laparoscopic approach seemed to show relevant advantages compared to open appendectomy, but a large prospective trial is necessary to collect high quality data and investigate long-term outcomes
Sporadic Carcinoma of the Colon–Rectum in Young Patients: A Distinct Disease? A Critical Review
No full textDiagnosis and Treatment of Primary Tumors of the Appendix: a Critical Review
No full textIntroduction: The aim of the current paper was to critically collect, select and summarize the evidence regarding diagnosis, treatment and follow up of primary tumors of the appendix. Methods: A literature review was performed by search and review of the scientific studies pertaining to the subject of our inquiry. Results: Recommendations regarding pimary tumors of the appendix were formulated on the basis of the collected evidence. Conclusion : Primary tumors of the appendix are rare and a high index of suspicion is required not to miss a potentially life threatening medical condition
Extensive surgery and lymphadenectomy do not improve survival in primary melanoma of the anorectum: results from analysis of a large database (SEER)
No full textPrimary anorectal melanoma is a rare disease with a dismal prognosis due to early distant metastasis. The prognostic value of positive loco-regional lymph nodes and the impact of lymphadenectomy on overall survival is unclear. We have investigated this by analysis of data obtained from a national representative database, controlling for potential confounders
BRAFV600E Mutation Does Not Mean Distant Metastasis in Thyroid Papillary Carcinomas
No full textContext: The oncogenic BRAFV600E mutation has been frequently associated with aggressive behavior of papillary thyroid carcinomas. However, controversy exists on the consistency of these data, and very little is known about the relationship between this genetic alteration and the tendency of papillary thyroid carcinoma (PTC) to develop metastasis at distant sites. Study Design: We analyzed by direct sequencing the frequency of BRAFV600E mutation within a group of 47 highly aggressive PTC, which had developed distant metastases. As control, we analyzed the BRAFV600E mutation in a group of 75 PTC without distant metastases who were disease free for a minimum 7-yr follow-up. Results: The BRAFV600E mutation was present in 29.8% of the distantly metastatic PTC, whereas it was detected in about 44.0% of the control tumors. Conclusion: These results clearly prove that the BRAFV600E mutation is not associated with the development of distant metastases or fatal outcome in PTC and may not predict aggressive behavior in this type of tumor. (J Clin Endocrinol Metab 97: E1745-E1749, 2012
Il rapporto tra l'uomo e gli animali. Progetto di educazione e promozione della salute dell'ASL 7 di Siena
No full textAcute chest pain and esophageal mucosal injury following an extreme yoga position: Case report
Full text linkA young lady complained of the sudden onset of intense chest pain, in consequence of an extreme hyperextension of the back in a yoga position. At endoscopy a large lesion of the esophageal epithelium was detected, involving the middle third of the anterior wall of the esophagus. Other symptoms reported by the patient were dysphagia and odynophagia, depicting the typical features of intramural hematoma, also known as intramural dissection or intramural perforation of the oesophagus. The patient was managed conservatively and symptoms disappeared within a week. A barium swallow at six months reported normal findings. Different types of accidents occurring during yoga practice are reported in the literature, mainly involving musculoskeletal or nervous systems. Visceral lesions are exceptional and no similar cases have been reported in the literature
Valutazione dell’efficacia di interventi educativi per la prevenzione del fumo in adolescenza
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