1,279 research outputs found
Social turkey
No full textSocial Turkey is a short digital dance video developed\ud
over a series of weekly meetings with a group of\ud
sprightly and defiant sixty-plus year olds resident in\ud
Limerick. Very early in the process artist Ciara\ud
Finnegan and choreographer Jenny Roche found\ud
each individual expressing a wonderful enthusiasm\ud
for dance, an eagerness to perform and a healthy\ud
refusal to conform to stereotypes of aging. Finnegan\ud
was keen that this project should support an\ud
exchange of ideas rather than employ a top-down\ud
directorial structure. While Roche devised the\ud
fundamentals of the dance and Finnegan manned\ud
the camera, each participant contributed thereafter -\ud
improvising on a step sequence and collaborating on\ud
patterns that ultimately determined much of the look\ud
of the result. The work seeks to amplify the\ud
represented interests of a wider community while\ud
celebrating the vivacity of the particular group and\ud
the sheer fun of the collaboration
Review of van der Meulen and Heynen’s Expanding the Gaze: Gender and the Politics of Surveillance
No full textPRC2.1 and PRC2.2 Specific Accessory Proteins Drive Recruitment of Different Forms of Canonical PRC1
No full textPRC2.1 and PRC2.2 Specific Accessory Proteins Drive Recruitment of Different Forms of Canonical PRC1.Eleanor Glancy1*, Cheng Wang1*, Ellen Tuck1, Evan Healy1, Simona Amato2, Hannah K. Neikes3, Andrea Mariani2, Marlena Mucha1, Michiel Vermeulen3, Diego Pasini2,4, Adrian P. Bracken1,5.1Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.2IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy.3Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands.4University of Milan, Via A. di Rudini 8, Department of Health Sciences, 20142 Milan, Italy.*These authors contributed equally.5Lead Contact.*Corresponding author: Adrian P. Bracken ([email protected]).Summary: Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is believed to direct recruitment of canonical PRC1 (cPRC1) to promote stable repression of developmental genes. PRC2 forms two major subcomplexes, PRC2.1 and PRC2.2, but their specific roles remain unclear. Through genetic knockout and replacement of PRC2 subcomplex-specific accessory proteins, we discover that PRC2.1 and PRC2.2 function through distinct mechanisms. During the transition from naïve to primed pluripotency, PRC2.1 accumulates in sharp defined peak-like profiles at CpG islands, dependent on the DNA and histone modification binding activities of MTF2. In contrast, PRC2.2 is recruited in broader profiles, mirroring H2AK119ub1 accumulation, dependent on the ubiquitin-binding abilities of JARID2 and AEBP2. Surprisingly, we uncover distinct roles for PRC2.2 and PRC2.1 specific accessory proteins in specifically mediating the recruitment of either CBX7- or CBX2/4- containing canonical PRC1 (cPRC1), respectively. PRC2.1 mediates the majority of H3K27me3 deposition at Polycomb target genes, which is sufficient to promote recruitment of CBX2/4-cPRC1, but not CBX7-cPRC1. Conversely, while PRC2.2 is poor at mediating H3K27me3 deposition, we find that JARID2 is essential for recruitment of CBX7-cPRC1 and its consequent 3D chromatin interactions at Polycomb target genes. We therefore define distinct contributions of PRC2.1 and PRC2.2 specific accessory proteins to Polycomb mediated repression and uncover distinct mechanisms for cPRC1 recruitment.Highlights •PRC2.1/PRC2.2 are co-recruited to promote de novo Polycomb target gene repression.•PRC2.1 binds in sharp peaks specialising in H3K27me3 deposition and CBX2/4-cPRC1 recruitment.•PRC2.2 binds in broader H2AK119ub1-like profiles and has weak H3K27me3 acivity.•PRC2.2 component JARID2 specifically recruits CBX7-cPRC1. Keywords: Polycomb, PRC2.1, PRC2.2, H3K27me3, JARID2, Polycomb-like protein, PRC1, CBX2, CBX4, CBX7
Domestic drones: the politics of verticality and the surveillance industrial complex
No full textDrones are being introduced as innovative and
cost-effective technologies for civil, commercial, and recreational purposes
in the domestic realm. While the presence of these technologies is
increasing, regulations are being introduced in order to ensure their safe
and responsible use. As drones are adopted for a number of purposes, the
“de facto practices settle around it, rendering change much more
difficult” (Gersher, 2014), and so the policy debates must consider all
contingencies and unintended consequences of their use. This paper discusses
the background of unmanned aerial vehicles (UAVs), their role as surveillance technologies, and how
they reinforce asymmetries in power and visibility that contribute to a
politics of verticality, ultimately arguing that surveillance concerns must
become part of the discussion at the policy and regulatory level in order to
mitigate any harms. Where drones are already used for care and control as
technologies of surveillance, privileged use of drones by public and police
agencies could further reinforce a politics of verticality (Weizman, 2002),
resulting in specific types of space, risk, and population management
Handwritten note by Judge Michael J. Roche
No full textNote by United States District Judge Michael J. Roche: "Filed July 2, 1943 In the above-entitled cause it appearing upon the face of the petition that petitioner is not entitled to a writ of habeas corpus, and it further appearing that she has not exhausted her administrative remedies under the provisions of Executive Order No. 9102 (7 Fed. Reg. 2165) and the regulations promulgated thereunder, IT IS THEREFORE ordered that the petition for a write of habeas corpus be, and the same is, hereby denied, dated: July 2, 1943." Note is written on the back of a document titled "Statement of Oswald Garrison Villard on Chinese Exclusion before the H. R. Committee on Immigration and Naturalization on May 20, 1943."The ACLU-Northern California case file records contain legal documents and correspondence pertaining to the case Ex parte Mitsuye Endo (1944), in which the United States Supreme court unanimously ruled that the federal government could not indefinitely detain United States citizens who were loyal to the government. Files include documents related to the Gordon Hirabayashi Supreme Court case Hirabayashi v. United States
Teaching Theories of Urbanism
No full textThis chapter introduces the theories of urbanism courses offered at the Urbanism Department in the Faculty of Architecture and the Built Environment, TU Delft. Urbanism is a discipline which has a crucial impact on how humans interact with the built environment. Understanding its theories is important and will be increasingly so in the twenty-first century as the world’s population becomes ever more urban. This chapter begins with a brief introduction outlining its contents. Section two then asks the question What is urbanism? and answers it by looking at how cities developed before going on to describe the discipline of urbanism itself. Section three highlights three theories of urbanism courses run by the Urbanism Department, showcasing their teaching methods, and showing how they are targeted to students’ different levels. The course deliverables, which are essays, are also explained here, including how they are graded and the feedback given. Section 4 deals with the courses’ learning objectives, explaining both explicit and implicit ones: the former being about understanding theories of urbanism and demonstrating that understanding; the latter being about professionalism more generally, e.g. how to communicate, meet deadlines, and write academically correct English. Finally, a brief conclusion recapitulates the importance of urban theory in the twenty-first century.Spatial Planning and Strateg
The secondary punishment: a scoping study on employer attitudes to hiring people with criminal convictions.
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