22,356 research outputs found
TRP Channels in Dental Pain
No full textDespite the high incidence of dental pain, the mechanism underlying its generation is mostly unknown. Functional expression of temperature-sensitive transient receptor potential (thermo-TRP) channels, such as TRPV1, TRPV2, TRPM8, and TRPA1 in dental primary afferent neurons and TRPV1, TRPV2, TRPV3, TRPV4, and TRPM3 in odontoblasts, has been demonstrated and suggested as responsible for dental pain elicited by hot and cold food. However, dental pain induced by light touch or sweet substance cannot be explained by the role of thermo-TRP channels. Most of current therapeutics of dentin hypersensitivity is based on hydrodynamic theory, which argues that light stimuli such as air puff and temperature changes cause fluid movement within dentinal tubule, which is then transduced as pain. To test this theory, various TRP channels as candidates of cellular mechanotransducers were studied for expression in dental primary afferents and odontoblasts. The expression of TRPV1, TRPV2, TRPA1, TRPV4, and TRPM3 in trigeminal neurons and TRPV1, TRPV2, TRPV3, TRPV4 and TRPM3 in odontoblasts has been revealed. However, their roles as cellular mechanotransducers are controversial and contribution to generation of dental pain is still elusive. This review discusses recent advances in understanding of molecular mechanism underlying development of dental pain. © Chung and Oh; Licensee Bentham Open.N
Korean music
No full textHan oh baek nyun ; Goo cho daeng gi ; Hwe sim kok ; Shi jo (Cheong sanri byeok kye soo ya) ; Jebi-Ka ; Jejun ; Honamka (with kayageum) ; Choonhyang-jun (only sarang ka) ; Instrumental music of peasants ; Soo je chun ; Chung sung ja jin han ip ; Nak yang choon ; Soo ryong um ; Ung an ji ak ; Tae pyung ka ; Chun nyun man sei ; Yum yang choon.Digitoitu 31. 12. 2008Kotelossa kappaleiden kohdalla sivunumerot ja merkintä "Reference; Korean Music by Chang Sa-Hun", ilmeisesti äänite liittyy siis tämännimiseen kirjaan
Impacts of glycans attached to therapeutic glycoproteins
No full textHigh value-added therapeutic proteins have been
leading the biologics industry and occupied major portion of
the market. More than 60% of the currently available protein
therapeutics are glycoproteins attached with glycans which
play crucial roles for the protein folding, therapeutic efficacy,
in vivo half-life and immunogenecity. This review
introduces the process of glycosylation and the impacts of
glycans in the aspects of therapeutics. The important glycan
structures in therapeutic performances were also summarized
focusing on three representative categories of glycoproteins,
cytokines, therapeutic antibody and enzyme. Currently,
mammalian expression systems such as Chinese hamster
ovary cells are preferred for the production of therapeutic
glycoproteins due to their ability to synthesize glycans
having similar structures with human type glycans. However,
recent advances of plant glycoengineering to overcome
the limitation originating from different glycan structures
will soon allow to develop more efficient and economic
plant-based production systems for therapeutic glycoproteins.open
Selectively Patterned Nanoplasmonic Nanoprobes for Microfluidic Surface-Enhanced Raman Spectroscopy
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Will investments in human resources during the COVID-19 pandemic crisis pay off after the crisis?
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