62,850 research outputs found
Prevalence of chronic kidney disease in Nigeria: systematic review of population-based studies
No full textInnocent Ijezie Chukwuonye,1 Okechukwu Samuel Ogah,2 Ernest Ndukaife Anyabolu,3 Kenneth Arinze Ohagwu,1 Ogbonna Collins Nwabuko,4 Uwa Onwuchekwa,5 Miracle Erinma Chukwuonye,6 Emmanuel Chukwuebuka Obi,1 Efosa Oviasu7 1Division of Nephrology, Department of Internal Medicine, Federal Medical Centre, Umuahia, Abia State, 2Division of Cardiology, Department of Internal Medicine, University College Hospital Ibadan, Oyo State 3Division of Nephrology, Department of Internal Medicine, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital Awka, Anambra State, 4Department of Haematology, Federal Medical Centre, Umuahia, 5Division of Nephrology, Department of Internal Medicine, Abia State University Teaching Hospital, Aba, 6Department of Family Medicine, Federal Medical Centre, Umuahia, 7Division of Nephrology, Department of Internal Medicine, University of Benin Teaching Hospital, Benin City, Nigeria Background: The aim of this study was to identify and discuss published population-based studies carried out in Nigeria that have information on the prevalence of chronic kidney disease (CKD) and have also used the Kidney Disease Outcomes Quality Initiative (KDOQI) practice guidelines in defining CKD, with emphasis on the performance of three estimating equations for glomerular filtration rate (GFR) – Modification of Diet in Renal Disease (MDRD), Cockcroft–Gault, and CKD epidemiology collaboration (CKD-EPI) creatinine equation. Materials and methods: A systematic literature search was carried out in Google, MEDLINE, PubMed, and AJOL database, with the aim of identifying relevant population-based studies with information on the prevalence of CKD in a location in Nigeria. Results: Seven cross-sectional population-based studies were identified. Two of the studies used the Cockcroft–Gault and observed a prevalence of 24.4% and 26%. Four of the studies used the MDRD and the prevalences observed were 12.3%, 14.2%, 2.5%, and 13.4%. One of the studies used the CKD-EPI equation and the prevalence was 11.4%. The male to female ratios of CKD prevalence in six studies were 1:1.9, 0.8:1, 1:1.6, 1:2, 1:1.8, 1:1.4, and the observed risk factors in the studies were old age, obesity, diabetes mellitus, hypertension, family history of hypertension, family history of renal disease, low-income occupation, use of traditional medication, low hemoglobin, and abdominal obesity. Conclusion: The prevalence of CKD was high but variable in Nigeria, influenced by the equation used to estimate the GFR. MDRD and CKD-EPI results are agreeable. There is a need for more population-based studies, with emphasis on repeating the GFR estimation after 3 months in subjects with GFR <60 mL/min/1.7 m2. Keywords: CKD, Cockcroft–Gault, Modification of Diet in Renal Disease, CKD epidemiology collaboration creatinine equatio
Die Werteerziehung im Lehrwerk Johannes Pauls II.
No full textAn in‑depth analysis of writings of John Paul II leads to a conclusion that the Pope cared for upbringing that would foster to values. He clearly indicated that the person is to be viewed as the foundation of the process of upbringing and also stressed the significance of upbringing towards life in the family, nation and Church. The author of this article accounts for and presents the problem of upbringing towards values, which is interpreted from the teachings of John Paul II. First, the author indicates the complementary character of education, religion and faith, then they are oriented towards the world of values and the Christian hierarchization of these values
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
No full textMaternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
Święty Jan Paweł II o duchowości laikatu
No full textThe author of this article shows input of saint John Paul II in the understanding of spirituality of lay people. The article proves that the papal teaching about the laity is a continuation of the teaching of The Second Vatican Council and also brings some new elements. The particular attention paid to the communion dimension of the Church should be emphasized. The author also discusses the participation of lay people in the threefold office of the Christ, incarnational dimension of the lay spirituality and the question of the common call to sanctity.Autor artykułu ukazuje wkład św. Jana Pawła II w rozumienie duchowości ludzi świeckich. Udowadnia, że nauczanie papieża na temat laikatu stanowi kontynuację nauczania Soboru Watykańskiego II, ale wnosi też nowe akcenty. Na podkreślenie zasługuje szczególny akcent położony na komunijny wymiar Kościoła. Autor omawia też udział świeckich w potrójnym urzędzie Chrystusa, inkarnacyjny wymiar duchowości laikatu i kwestię powszechnego powołania do świętości
Święty Jan Paweł II o duchowości chrześcijańskiego Wschodu
No full textThe author of the article shows the major themes of the teaching of Saint John Paul II on Eastern Christian spirituality. He indicates the pope’s personal interest in the culture, especially philosophy and art developed in the orthodox environment. The article also presents the pope’s ecumenical efforts and the related difficulties. On the broader theological basis the author elaborates the most important elements of the orthodox spirituality, which the Slavic pope pointed out during his long pontificate.Autor artykułu ukazuje główne linie nauczania św. Jana Pawła II na temat duchowości chrześcijańskiego Wschodu. Wskazuje na osobiste zainteresowania papieża kulturą, zwłaszcza filozofią i sztuką rozwijaną w kręgu prawosławia. Ukazuje również wysiłki ekumeniczne i związane z nimi trudności. Na szerszym fundamencie teologicznym autor rozwija główne elementy duchowości prawosławnej, na jakie zwracał uwagę słowiański papież w czasie swego długiego pontyfikatu
Multiple myeloma in Niger Delta, Nigeria: complications and the outcome of palliative interventions
No full textOgbonna Collins Nwabuko,1,2 Elizabeth Eneikido Igbigbi,3 Innocent Ijezie Chukwuonye,4 Martin Anazodo Nnoli5 1Department of Haematology, Federal Medical Center, Umuahia, 2Department of Haematology, College of Health Science, Abia State University, Aba, Abia State, 3Department of Haematology, Blood Transfusion and Immunology, Faculty of Basic Medical Sciences, University of Port Harcourt, Port Harcourt, 4Department of Internal Medicine, Federal Medical Center, Umuahia, 5Department of Anatomic Pathology, University of Calabar, Calabar, Nigeria Background: Multiple myeloma (MM) is one of the hematological malignancies that require palliative care. This is because of the life-threatening nature and the suffering associated with the illness. The aim of this study is to bring to the fore the complications experienced by people living with MM in the Niger-Delta region of Nigeria and the outcome of various palliative interventions.Methods: This was a 10-year multi-center retrospective study of 26 patients diagnosed and managed in three major centers in the Niger-Delta region of Nigeria from January 2003 to December 2012. Information on the clinical, laboratory, radiological data, and palliative treatment was obtained at presentation and subsequently at intervals of 3 months until the patient was lost to follow-up.Result: The mean duration from onset of symptoms to diagnosis was 13.12 months (95% CI, 6.65–19.58). A total of 16 (61.5%), eight (30.8%), and two subjects (7.7%) presented in Durie–Salmon (DS) stages III, II, and I, respectively. The complications presented by patients at diagnoses included bone pain (84.6%), anemia (61.5%), nephropathy (23.1%), and hemiplegia (35%). All the patients received analgesics, while 50.0% received blood transfusion, 56.7% had surgery performed, 19% had hemodialysis, and 3.8% received radiotherapy. A total of 10 (38%) patients benefited from bisphosphonates (BPs). A total of 57.6% of patients were on melphalan–prednisone (MP) double regimen, while 19% and 8% patients were on MP–thalidomide and MP–bortezomib triple regimens, respectively. A total of 3.8% of patients at DS stage IIIB disease had autologous stem-cell transplantation (ASCT). Only 7.6% of the myeloma patients survived up to 5 years post diagnosis. The overall mean survival interval was 39.7 months (95% CI, 32.1–47.2).Conclusion: Late diagnosis and inadequate palliative care account for major complications encountered by MM patients in the Niger-Delta region of Nigeria. This could be responsible for the poor prognostic outcome and low survival interval of MM individuals in this region. There is, therefore, a need to improve the quality of palliative care received by myeloma patients in this region. This is achievable via provision of relevant and affordable health care facilities for diagnosis and treatment of the disease. Keywords: multiple myeloma, palliative care, melphalan-prednisone, bone marrow plasma cells, autologous stem-cell transplantation, Niger Delt
Rola cudu w apologetyce przed II soborem watykańskim. Refleksja na podstawie analizy ówczesnych podręczników akademickich
No full textIn this article, the author made a reflection on the role of miracle in apologetics lecture before The Second Vatican Council. Looking for answers to this question, firstly the author presented the teaching of The First Vatican Council on miracle and its role. Then he analyzed several Polish academic textbooks of apologetics that had appeared before The Second Vatican Council in order to examine the function of miracle in relation to the Revelation.W niniejszym artykule autor podjął refleksję nad tym, jaka była rola cudu w wykładzie podręcznikowym apologetyki przed Vaticanum II. Szukając odpowiedzi na to pytanie, najpierw przedstawił nauczanie I Soboru Watykańskiego na temat cudu i jego roli. Następnie poddał analizie kilka polskojęzycznych podręczników akademickich do apologetyki, jakie pojawiły się przed II soborem watykańskim, aby zbadać w nich funkcję cudu w relacji do Objawienia
Evaluating the impact of type 2 diabetes mellitus on cardiovascular risk in persons with metabolic syndrome using the UKPDS risk engine
No full textO Stephen Ogedengbe,1 Ignatius U Ezeani,2 Ijezie I Chukwuonye,3 Ndukaife Anyabolu,4,5 Ikemefuna I Ozor,6 Aihanuwa Eregie1 1Department of Internal Medicine, University of Benin Teaching Hospital, Benin City, 2Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Federal Medical Center, Umuahia, 3Division of Nephrology, Department of Internal Medicine, Federal Medical Center, Umuahia, 4Division of Nephrology, Department of Internal Medicine, Imo State University Teaching Hospital, Orlu, 5Division of Nephrology, Department of Internal Medicine, Federal Medical Centre, Owerri, 6Division of Neurosurgery, Department of Surgery, University of Nigeria Teaching Hospital, Enugu, NigeriaBackground: The aim of this study is to evaluate the impact of coexistence of metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) on the estimated cardiovascular risk as calculated using the United Kingdom Prospective Diabetic Study risk engine (UKPDS-RE) and also to determine the impact of the coexistence of MS and T2DM on the 10-year risk of developing coronary heart disease and stroke.Methodology: This is a cross-sectional study in which convenience sampling technique was used to recruit 124 consecutive persons with T2DM and 96 controls using a questionnaire administered technique. The World Health Organization (WHO) criterion was used to define MS and the UKPDS-RE was used to identify persons with increased risk for stroke and those with increased risk for coronary heart disease. The data obtained were analyzed using SPSS version 16. Statistical comparisons were made with chi-square for comparison of proportions. A P-value of less than 0.05 was taken as statistically significant.Results: Fifteen subjects were identified as having an increased 10-year risk for stroke and ten as having an increased risk for a coronary event. The odds of a T2DM subject with MS having an increased risk for stroke compared with a T2DM subject without MS was 0.9579≈1 while the odds of a T2DM subject with MS developing an increased risk for a coronary event compared with a T2DM subject without MS was =3.451≈3.Conclusion: MS was more common in subjects with T2DM compared with controls (irrespective of the diagnostic criteria used) and MS appears to increase the risk of a coronary event in subjects with T2DM by threefold. Also from this study, MS did not appear to cause an additional increase in the risk of stroke in subjects with T2DM.Keywords: diabetes mellitus, metabolic syndrome, coronary heart disease, cardiovascular disease, UKPDS risk engin
Uniwersytecka „melodia”. Tarnowski przyczynek do współpracy międzynarodowej Uniwersytetu Papieskiego Jana Pawła II w Krakowie
No full textThe Erasmus exchange programme is one of the greatest culture and education programs, which helps students, teachers and administrative staff to explore and to grow their potential. Programme offers a chance to gain professional development through studying, teaching or training in a partner Higher Education Institution in Europe. Nine students and ten academic teachers from the Faculty of Theology, Section in Tarnow of the Pontifical University of John Paul II in Krakow have participated in programme since 2007. The author of this article presents contribution of the Faculty of Theology, Section in Tarnow to the international cooperation and development of the Pontifical University of John Paul II in Krakow.The Erasmus exchange programme is one of the greatest culture and education programs, which helps students, teachers and administrative staff to explore and to grow their potential. Programme offers a chance to gain professional development through studying, teaching or training in a partner Higher Education Institution in Europe. Nine students and ten academic teachers from the Faculty of Theology, Section in Tarnow of the Pontifical University of John Paul II in Krakow have participated in programme since 2007. The author of this article presents contribution of the Faculty of Theology, Section in Tarnow to the international cooperation and development of the Pontifical University of John Paul II in Krakow
Pastoralne implikacje encykliki Jana Pawła II Sollicitudo rei socialis
No full textThe canonization of Pope John Paul II constitutes a really great opportunity to rediscover the value of papal social thought. In this article, the author deals with the question of pastoral implications in the encyclical Sollicitudo rei socialis issued in 1987. The first part discusses the origins and socio – political context of the papal document. The second part presents the main ideas contained in the encyclical. The author analyses the range of problems present in the modern world, shows the integral understanding of human development and indicates the relationship between solidarity and peace. In the third and final part of the article, the author emphasizes the relevance of various aspects of the message contained in the encyclical and formulates particular indications for pastoral work. He draws attention to the necessity to enhance the social aspect of the Eucharist and the need to instil in believers attitudes of solidarity and responsibility for full human development, both on the individual and community level.Kanonizacja Jana Pawła II stanowi bardzo dobrą okazję do ponownego odkrycia wartości społecznej myśli papieża. W niniejszym artykule autor podejmuje kwestię duszpasterskich implikacji encykliki Sollicitudo rei socialis wydanej w 1987 roku. W pierwszej części omawia genezę i społeczno-polityczny kontekst papieskiego dokumentu. W drugiej części prezentuje najważniejsze idee zawarte w encyklice. Analizuje panoramę problemów współczesnego świata, przedstawia integralne rozumienie rozwoju człowieka oraz wskazuje na relacje między solidarnością i pokojem. W trzeciej i zarazem ostatniej części artykułu autor podkreśla aktualność wielu aspektów przesłania zawartego w encyklice oraz formułuje konkretne wskazania dla duszpasterstwa parafialnego. Zwraca uwagę na konieczność dowartościowania społecznego aspektu Eucharystii oraz na potrzebę kształtowania u wierzących postawy solidarności i odpowiedzialności za pełny rozwój człowieka zarówno w wymiarze indywidualnym, jak i wspólnotowym
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