3,897 research outputs found
Food habits of three carnivore species (Viverricula indica, Herpestes urva, and Melogale moschata) in Fushan Forest, northern Taiwan.
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Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death.
No full textThe concept of peace in the Tao Te Ching
No full textThis thesis represents a first attempt to analyze Lao Tzu's main method of resolving the social and political problems in Ch'un Ch'iu and Warring States Periods. Lao Tzu, the founder of Taoism, suggested many solutions that could bring an end to the conflicts and to the ending of the disunity of China. Examples of these include the reform or abolishment of some ancient Chinese institutions as well as new principles for the enhancement and preservation of life. All these ideas were to become crystallised in Tao Te Ch'ing, which became an important religious text. In particular, the aspect of Lao Tzu's methods for solving the social and political problems of China in the Warring States Period needs more attention. In each chapter of the Tao Te Ch'ing there was a main emphasis on peace as the main method of developing social cohesion and as a cure to all fundamental human problems. Therefore, Lao Tzu's ideas about peace and his methods of solving the problems of the Warring States period are significant and from the main focus of the thesis
Exploring the concept of the (future) mobile office
No full textThis video shows a concept of a future mobile office in a semi-automated vehicle that uses augmented reality. People perform non-driving tasks in current, non-automated vehicles even though that is unsafe. Moreover, even for passengers there is limited space, it is not social, and there can be motion sickness. In future cars, technology such as augmented reality might alleviate some of these issues. Our concept shows how augmented reality can project a remote conversant onto the dashboard. Thereby, the driver can keep an occasional eye on the road while the automated vehicle drives, and might experience less motion sickness. Potentially, this concept might even be used for group calls or for group activities such as karaoke, thereby creating a social setting. We also demonstrate how integration with an intelligent assistant (through speech and gesture analysis) might save the driver from having to grab a calendar to write things down, again allowing them to focus on the road
Natalia LL - artystka neoawangardowa
No full textThe paper shows Natalia Lach-Lachowicz (Natalia LL) as a neo avant-garde artist whose works in a specific maximalistic way are very close to the main currents of avant-garde trends: new mediality (photography), minimalism, conceptualism, performance, bodyart, pop-art, and feminist art. The author of the article concentrates mainly on the mutual influences of conceptualism, consumptionism, and feminism in Natalia LL’s works and pays attention to the emancipatory potential of her works of the seventies and the eighties
Energy flux in isotropic turbulence under large variations of external forcing
No full textWe investigate the response of energy flux in isotropic turbulence to step-function like perturbation in external forcing at large length scales. From both physical experiments and direct numerical simulations, we measured the evolution of the Eulerian velocity structure functions, such as , , before and after the perturbation in forcing. In both cases, we observed the cascade of the energy excess at large scales cascade through scales to the dissipative range, which can be used to study the dynamics of the cascade, and in particular, to estimate the relevant time scales
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Some rhetorical strategies in later nineteenth-century laboring-class poetry
No full textStructural and functional analysis of the pro-domain of human cathelicidin, LL-37
No full textCathelicidins form a family of small host defense peptides distinct from another class of cationic antimicrobial peptides, the defensins. They are expressed as large precursor molecules with a highly conserved pro-domain known as the cathelin-like domain (CLD). CLDs have high degrees of sequence homology to cathelin, a protein isolated from pig leukocytes and belonging to the cystatin family of cysteine protease inhibitors. In this report, we describe for the first time the X-ray crystal structure of the human CLD (hCLD) of the sole human cathelicidin, LL-37. The structure of hCLD, determined at 1.93 Å resolution, shows the cystatin-like fold and is highly similar to the structure of the CLD of the pig cathelicidin, protegrin-3. We assayed the in vitro antibacterial activities of hCLD, LL-37 and the precursor form, pro-cathelicidin (also known as hCAP18), and we found that the unprocessed protein inhibited the growth of Gramnegative bacteria with efficiencies comparable to the mature peptide, LL-37. In addition, the antibacterial activity of LL-37 was not inhibited by hCLD intermolecularly, since exogenously added hCLD had no effect on the bactericidal activity of the mature peptide. hCLD itself lacked antimicrobial function and did not inhibit the cysteine protease, cathepsin L. Our results contrast with previous reports of hCLD activity. A comparative structural analysis between hCLD and the cysteine protease inhibitor stefin A showed why hCLD is unable to function as an inhibitor of cysteine proteases. In this respect, the cystatin scaffold represents an ancestral structural platform from which proteins evolved divergently, with some losing inhibitory functions
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