7,761 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Full text linkThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Selective reaction of camphor-derived exo-formyl [2.2.1]bicyclic carbinol with alkyl primary amines: application to the preparation of new chiral catalysts for asymmetric reduction of aryl ketones
No full text[[abstract]]Reaction of camphor-derived exo-formyl [2.2.1]bicyclic carbinol with various alkyl primary amines gave regio- and stereo-specific [3.2.1]bicyclic alpha-amino ketones. A detailed mechanism of the reaction was discussed. This reaction was further applied to the preparation of some camphor-derived oxazaborolidines, one of which proved to be an efficient chiral catalyst for the asymmetric borane reduction of prochiral aryl ketones at room temperature. (C) 2010 Elsevier Ltd. All rights reserved.[[note]]SC
Condensation-ring Expansion Reaction of Formyl[2.2.1]bicyclic Carbinols with Para-substituted Phenyl Amines: Application to the Preparation of [3.2.1]bicyclic N-aryl-1,2,3-oxathiazolidine-2-oxide Agents
No full text[[abstract]]Individual reaction of camphene-derived endo-formyl[2.2.1]bicyclic carbinol and that of camphor-derived exo-formyl[2.2.1]bicyclic carbinol with parent and para-substituted phenyl amines gave regio- and stereospecific corresponding [3.2.1]bicyclic (para-substituted) phenyl amino ketones. Mechanism of each reaction was discussed. Some camphor-derived [3.2.1]bicyclic amino ketones were reduced to [3.2.1]bicyclic (para-substituted) phenyl amino alcohols, which were then treated with mesyl chloride to provide [3.2.1]bicyclic N-phenyl/aryl-1,2,3-oxathiazolidine-2-oxide agents. The mechanism of this final reaction was discussed as well.[[note]]SC
An ‘axe for the frozen sea’ : Estrin’s magic agential realism, insect thigmotaxis, and the problem with Kafka
Full text linkThis paper seeks to demonstrate how Marc Estrin’s Insect Dreams: the Half Life of Gregor Samsa constitutes the first piece of magic agential realist literature about insects. The term ‘magic agential realism’ has been coined from an observed coincidence in the literary commitments of Estrin’s novel to the literary genre of magic realism and the posthumanist assumptions it shares with the agential realism of Karen Barad. Given Kafka’s axiom that a literary work ought to function as an ‘axe for the frozen sea within us’. A further claim will be defended is the claim that Estrin’s Insect Dreams is the magic agential axe that shatters the frozen sea of liberal humanist representationalism within Kafka. In providing us with a book that affects us like a disaster and like a suicide (both of which are evoked and exceeded by the ever-more pressing concerns of posthumanism), I will demonstrate how Estrin both fulfils the literary criteria laid out by Kafka to Oskar Pollak and opens up the possibility of re-configuring ethics in order to account for insects through the observed phenomenon of thigmotaxis.peer-reviewe
Complications of varicella requiring hospitalization before and after the introduction of varicella vaccine in a Children’s Hospital in Taiwan
No full textFirst-principles investigation of the adsorption behaviors of CH <sub>2</sub> O on BN, AlN, GaN, InN, BP, and P monolayers
No full text CH 2 O is a common toxic gas molecule that can cause asthma and dermatitis in humans. In this study the adsorption behaviors of the CH 2 O adsorbed on the boron nitride (BN), aluminum nitride (AlN), gallium nitride (GaN), indium nitride (InN), boron phosphide (BP), and phosphorus (P) monolayers were investigated using the first-principles method, and potential materials that could be used for detecting CH 2 O were identified. The gas adsorption energies, charge transfers and electronic properties of the gas adsorption systems have been calculated to study the gas adsorption behaviors of CH 2 O on these single-layer materials. The electronic characteristics of these materials, except for the BP monolayer, were observed to change after CH 2 O adsorption. For CH 2 O on the BN, GaN, BP, and P surfaces, the gas adsorption behaviors were considered to follow a physical trend, whereas CH 2 O was chemically adsorbed on the AlN and InN monolayers. Given their large gas adsorption energies and high charge transfers, the AlN, GaN, and InN monolayers are potential materials for CH 2 O detection using the charge transfer mechanism. Electronic Components, Technology and Material
Quantum tight-binding chains with dissipative coupling
No full textGS acknowledges support from the EU FP7 projects FP7 People 2009 IRSES 247007 CACOMEL and FP7 People 2013 IRSES 612285 CANTOR. This work was also supported by the National Academy of Sciences of Belarus through the program 'Convergence', by the External Fellowship Program of the Russian Quantum Center at Skolkovo (D M, S K and E G) and by FAPESP grant 2014/21188-0 (D M), NK and DM acknowledge the support provided by the Scottish Universities Physics Alliance (SUPA). The research leading to these results has received funding from the European Community Seventh Framework Programme (FP7/2007-2013) under grant agreement n. 270843 (iQIT) Date of acceptance: 31/03/2015We present a one-dimensional tight-binding chain of two-level systems coupled only through common dissipative Markovian reservoirs. This quantum chain can demonstrate anomalous thermodynamic behavior contradicting Fourier law. Population dynamics of individual systems of the chain is polynomial with the order determined by the initial state of the chain. The chain can simulate classically hard problems, such as multi-dimensional random walks.Peer reviewe
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