1,980 research outputs found
Extension of timeline-based editing for non-deterministic temporal behavior in SMIL2.0 authoring
No full text[[abstract]]Timeline-based editing provides nonprofessional users an intuitive and friendly way for multimedia authoring, but the schedule-based and deterministic property of timeline results in the lack of the ability for Supporting non-deterministic temporal behavior, which is one of the key features of SMIL2.0. This paper presents our elaborate effort of supporting non-deterministic temporal behavior by timeline-based editing. The concept of Dividable Dynamic Timeline (DDTL) is proposed in the paper, which includes two novel features: dividable timeline and dynamic section. With DDTL, authors can create interactive multimedia presentations while enjoying the convenience of timeline. Mechanisms of converting from DDTL editing results to SMIL2.0 and the reuse of SMIL2.0 scripts are presented in the paper. By the reuse of existing SMIL2.0 scripts and the flexible features of DDTL, an efficient and friendly authoring environment for SMIL2.0-based interactive multimedia presentations can be provided. Implementation of the system provides a friendly WYSIWYG environment and multiple views/windows are provided by the systems to help SMIL2.0 authors compose multimedia presentations efficiently.[[note]]SC
Ck-Log, A Calculus for Knowledge Processing in Logic
No full textThis paper introduces the principal concepts in the organization and operation of the logic based knowledge processing system, called CK-LOG (A Calculus for Knowledge in Logics). CK-LOG uses the frame based system MDS (the Meta Description System) for knowledge representation and for modeling world states. It uses an inference engine based on Natural Deduction for stating and solving problems. As a knowledge processing system CK-LOG has several capabilities, which are new to the technology of knowledge representation systems: CK-LOG has special facilities to represent and reason about actions and their time dependencies. Actions that occur in a world state may create or destroy objects in the world or modify their properties, or prevent or support other actions. The effects of actions are described in CK-LOG using modal operators like CREATE, DESTROY, PREVENT, SUPPORT, KEEP, etc. These operator expressions are also used to represent and reason about possible worlds that the actions might lead to. Most significantly, CK-LOG is a logic-based knowledge processing system, just as PROLOG is logic based programming system. CK-LOG uses a three valued logical system with truth values T (true),? (Unknown) and F (false) to build partial models of world states, and the two valued logic's system of T and F in its theorem proving System. The use of the three valued logical system in its models of world states enables CK-LOG to do problem solving in the context of incomplete information about world states. The theorem proving system of CK-LOG uses a variant of the calculus of sequents first proposed by Kanger (which itself is a variant of Gentzen's system). The two variations in CK-LOG are, (i). the use of a new algorithm called the mating algorithm for testing proof terminations, and (ii) the use of specialized inference rules for reasoning about modal expressions using the possible world semantics.. The mating algorithm gives the theorem proving system of CK-LOG several new capabilities: to identify information that is pertinent to a given problem and retrieve it from its knowledge base, to update its models of possible worlds during the problem solving process based on the findings of the theorem proving system, to use these models of world states to test proof terminations, and to generate hypotheses during the problem solving process that are based on unknown information. These various features of CK-LOG are described here. The paper concludes with a discussion of the logic of frames as used in CK-LOG and establishes a condition called locality condition as a sufficient condition for creating knowledge representations with requisite completeness.Technical report DCS-TR-15
Highly parallel and energy-efficient exhaustive minimum distance search engine using hybrid digital/analog circuit techniques
No full textA minimum distance search engine (MDSE) is presented as a hardware. accelerator for various exhaustive pattern-matching systems. This chip executes highly parallel computations of L-1-norms between an input query and stored multiple reference records, and searches for the minimum distance among them in a highly parallel fashion. Our architectural-level estimation shows that this MDSE can reduce energy dissipation by orders of magnitude as the number of records increases, compared with the conventional systems. We have designed a prototype 4-bit 8-word MDSE composed of merged memory logic (MML) and digital/analog-mixed winner-take-all circuit (DAM-WTAC) by using hybrid digital/analog circuit techniques. It was fabricated with a 0.6-mum single-poly triple-metal CMOS technology. Experimental results show that our chip works properly at 3 V/10 MM and has approximately four times larger throughput as well as four times higher energy efficiency, compared with the existing 8-bit microcontrollers.The author would like to thank MICROS, IDEC and Samsung Electronics
Company for their support. They would also like to thank the
reviewers for their valuable comments and Dr. K. Kim, Samsung Electronics
Company, for useful discussion
Involvement of p29 in DNA damage responses and Fanconi anemia pathway.
No full text[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Drexel&SrcApp=hagerty_opac&KeyRecord=0143-3334&DestApp=JCR&RQ=IF_CAT_BOXPLO
Common and specific sequences between CK and TR lirbary.
No full text<p>Common and specific sequences between CK and TR lirbary.</p
Variability study of Si nanowire FETs with different junction gradients
Full text linkRandom dopant fluctuation effects of gate-all-around Si nanowire field-effect transistors (FETs) are investigated in terms of different diameters and junction gradients. The nanowire FETs with smaller diameters or shorter junction gradients increase relative variations of the drain currents and the mismatch of the drain currents between source-drain and drain-source bias change in the saturation regime. Smaller diameters decreased current drivability critically compared to standard deviations of the drain currents, thus inducing greater relative variations of the drain currents. Shorter junction gradients form high potential barriers in the source-side lightly-doped extension regions at on-state, which determines the magnitude of the drain currents and fluctuates the drain currents greatly under thermionic-emission mechanism. On the other hand, longer junction gradients affect lateral field to fluctuate the drain currents greatly. These physical phenomena coincide with correlations of the variations between drain currents and electrical parameters such as threshold voltages and parasitic resistances. The nanowire FETs with relatively-larger diameters and longer junction gradients without degrading short channel characteristics are suggested to minimize the relative variations and the mismatch of the drain currents. (C) 2016 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).1163Ysciescopu
Immune-mediated myopathy related to anti 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies as an emerging cause of necrotizing myopathy induced by statins
No full textInternational audienceImmune-mediated necrotizing myopathy (IMNM) associated with statin use and anti 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMGCR) antibody is a new and emerging entity that supports a link between statin use and IMNM and raises the questions of distinct clinical phenotypes and treatment strategy. We describe the clinical and histopathological characteristics of a patient and discuss the spectrum of IMNM and statin-induced myopathies. A 65-year-old man was suffering from proximal muscle weakness and elevated CK levels, following exposure to statin therapy. The symptoms worsened despite discontinuation of the drug. At that point, no myositis-specific or -associated antibodies were detected. Malignancy screening did not reveal abnormalities. Muscle biopsy demonstrated a predominantly necrotizing myopathy with minimal lymphocytic infiltrates, MHC class I expression in necrotic muscle fibers, and complement deposition on scattered non-necrotic muscle fibers. Muscle protein analysis by western blot was normal. The patient did not improve with steroid and methotrexate and required monthly intravenous immunoglobulin (IVIG) therapy. Muscle strength gradually improved, CK levels normalized and IVIG were stopped 1 year later. Screening for anti-HMGCR antibodies, not available at the time of presentation, was highly positive. Identification of anti-HMGCR antibodies in statin-exposed patients with myopathy appears to be helpful both for differential diagnosis and for treatment strategy. In patients who did not improve after discontinuation of the statin treatment, a muscle biopsy should be performed as well as screening for anti-HMGCR antibodies. Patients with this disorder require aggressive immunosuppressive treatment.</div
Radical-Mediated Peptide Tyrosine Nitration In Vacuo: Experimental Evidence and Theoretical Examination
No full textProtein tyrosine nitration (PTN)—a hallmark of post-translational modification of proteins under nitrative stress in vivo—modification is believed to occur regioselectively and site-specifically at diverse local sequences with no observed consensus modification motif.1 The mechanistic details governing the site-specificity of the ortho-tyrosine nitration are largely unknown. Herein, the mechanism of radical-mediated PTN has been elucidated in detail at the molecular level using an integrated approach combining gas phase synthesis of prototypical tyrosine-containing peptide radical cations, ion–molecule reactions with nitrogen dioxide, isotopic labelling MS experiments, and DFT calculations at the B3LYP/6-31++G** level of theory. First, π-centered molecular radical cationic tyrosine-containing peptides were generated in situ through collision-induced intramolecular one-electron transfer oxidation of copper(II)–peptide complexes In Vacuo.2,3 The representative radical cationic tyrosine-containing tetrapeptide was mass-selected, trapped, and reacted with •NO2. Recombination of •NO2 with radical cationic peptide led to a substantial yield of a stable closed-shell nitrated product. Our experimental and theoretical investigations into radical-mediated tyrosine nitration revealed the necessity for phenoxyl radical formation prior to the production of distinct 3-nitrotyrosine (3-NT) products, which are influenced by the location of the radical site and the tautomerization barriers for radical and proton mobility; 3,4 a two-step mechanism, involving the generation of phenoxyl radical intermediates with viable isomerization
barriers (<10 kcal mol–1) and concerted proton rearrangement prior to the formation of the stable
closed-shell ortho-nitration product of the tyrosyl residue, has been determined unambiguously. The
spin state of the phenoxyl radical governs the regioselectivity of the ortho-tyrosine nitration (3-NT).
To better understand the site-specific formation of endogenous PTNs, the fundamental factors
governing the site-specificity of the 3-NT have been investigated using computationally tractable
prototypical dityrosyl-containing peptides that mimic the local topological characteristics of peptides found in PTNs in vitro from a M. fascicularis model of cerebral ischemia; 5 these nitrated peptides have been validated and shortlisted as potential selectivity determinants for the model peptides in their subsequent gas phase PTN reactions; selective tyrosine nitrations have been verified in several other instances of prototypical dityrosyl-containing peptides. A crucial aspect of the formation of the site-specific nitrated product ions is that they are likely preceded by favorable interconversion barrier(s) to generate phenoxyl radical intermediate structures prior to the formation of distinct 3-NT products; the exact site of tyrosyl nitration also depends on the local sequence; the types and locations of the essential neighboring residues and their proximity to the tyrosyl residue appear to significantly influence the competition between the isomerization and the site-specific phenoxyl radical formation.
References:
1. Radi, R. Acc. Chem. Res. 2013, 46, 550-559.
2. Turecek, F.; Julian, R. R. Chem. Rev. 2013, 113, 6691-6733.
3. Laskin J. ; Yang Z.; Chu I. K. J. Am. Chem. Soc. 2008, 130, 3218-3230.
4. Chu I. K.; Zhao J.; Xu M.; Siu S. O.; Hopkinson A. C.; Siu K. W. M. J. Am. Chem. Soc. 2008, 130, 7862-7872.
5. Quan Q., Szeto S. S. W.; Law C. H.; Zhang Z.; Wang Y.; Chu I. K. Anal. Chem. 2015, 87, 10015- 1002
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