14,625 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Full text linkThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Dietary oxidized frying oil compromised vitamin A value of b-carotene in rats.(in Chinese)
No full textDistal Extension Denture – Case Report and Overview [Corrigendum]
No full textYeung C, Leung KCM, Yu OY, Lam WYH, Wong AWY, Chu CH. Clin Cosmet Investig Dent. 2020;12:493—503.
Details of the same case report were previously reported by the authors in Yeung C, Leung KCM, Yu OY, Lam WYH, Wong AWY, Chu CH. Prosthodontic Rehabilitation and Follow-Up Using Maxillary Complete Conventional Immediate Denture. Clin Cosmet Investig Dent. 2020;12:437–445.
Figures 1-5, 11 and 12-14 on pages 494, 496 and 497, respectively, should have included the following note:
Note: Copyright ©2020. Dove Medical Press. Reproduced from Yeung C, Leung KCM, Yu OY, Lam WYH, Wong AWY, Chu CH. Prosthodontic Rehabilitation and Follow-Up Using Maxillary Complete Conventional Immediate Denture. Clin Cosmet Investig Dent. 2020;12:437–445.
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Symphonie au CHU
Full text linkEntretien avec l'ingénieur Georges de Mullewie, le chef d'orchestre Pierre Bartholomée et l'administrateur du CHU Georges Bovy au sujet d'un concert symphonique organisé au Centre Hospitalier Universitaire du Sart Tilman, sur les conditions acoustiques, artistiques et symboliques d'un tel événement en milieu hospitalier et sous la verrière du CH
Increased carrying angle is an individual risk factor of non-traumatic ulnar neuropathy at the elbow.
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Generalized immunosppression-associated type kaposi’s sarcoma in a patient with severe refractory bullous pemphigoid.
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