4,914 research outputs found
Columbus, Christopher Inn on East Broad Street
No full textChristopher Inn [demolished in 1990's], Columbus, OhioColo
Predictive QSAR modeling of compounds inhibiting cytochrome P450 3A4-mediated metabolism of testosterone and 7-benzyloxy-4-trifluoromethylcoumarin
No full textEnzymes in the cytochrome P450 family are responsible for much of the first-pass metabolism of xenobiotic compounds. Within this family, the hepatic 3A4 isoform (CYP3A4) is responsible for the first-pass metabolism of over half of the drug compounds currently on the market. This substrate promiscuity increases the risk of dangerous drug-drug interactions (DDIs), in which a drug compound inhibits the metabolism of other compounds by CYP3A4, leading to drug inactivity or the accumulation of the non-metabolized drug in the body. These risks have led to numerous quantitative structure-activity relationship (QSAR) and SAR studies of CYP3A4 inhibitors to determine the structural characteristics common to inhibitor compounds. Evidence of multiple binding pockets necessitates the use of a variety of probe substrates, resulting in different. From the published literature and patents, we collected compounds with inhibition data against CYP3A4, using either 7-benzyloxy-4-trifluoromethylcoumarin (BFC) or testosterone (TST) as the probe substrate and measuring inhibition as –log10(IC50) (pIC50). We then developed QSAR models using two descriptor selection methods (random forest and genetic algorithm-k nearest neighbors (GA-kNN) and two descriptor sets (MOE and Dragon). The resulting eight models were validated via five-fold cross validation and external validation. While the cross-validation results are good for all models, most models had low external predictivity. By analyzing the models with the best external predictivity (those using Dragon descriptors and GA-kNN descriptor selection), we found several atom-type and P-VSA-like descriptors that showed a sizable difference in importance between the models from the BFC and TST data. These descriptors reflect studies from prior QSAR studies on characteristics of CYP3A4 inhibitors. Results from this study could be used to account for differences in in vitro inhibition screens using multiple probe substrates.M.S.Includes bibliographical referencesby Christopher Mayer-Baco
Neutral Network Analysis of the Lynx Data
No full text1 online resource (PDF, 32 pages)Mayer, C.; Bingham, Christopher. (1994). Neutral Network Analysis of the Lynx Data. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/199621
Jane Mayer, 32nd Annual ODU Literary Festival
No full textJane Mayer joined The New Yorker as a staff writer in 1995. She writes about politics for the magazine, and has been covering the war on terror. Recent subjects include Alberto Mora and the Pentagon’s secret torture policy, how the United States out-sources torture, the prison at Guantánamo Bay, and the legality of C.I.A. interrogations. She has also written about George W. Bush, the bin Laden family, and Sarah Palin. Mayer was the 2008 winner of the John Chancellor Award for Journalistic Excellence. She was also a 2009 finalist for the National Book Award and the National Book Critics Circle Award. Mayer is the author of the best-selling 2008 book The Dark Side: The Inside Story of How the War in Terror Turned into a War on American Ideals, which was chosen as one of the ten best books of the year by The New York Times, The Economist Magazine, Salon, Slate and Bloomberg
Columbus, Alphons Pelzer's statue of Christopher Columbus at the Ohio Statehouse
No full textColumbus monument and State House west façade, Columbus, OhioColo
POLICY SPACE: WHAT, FOR WHAT, AND WHERE?
No full textThe paper examines how developing countries can use existing policy space, and enlarge it, without opting out of international commitments. It argues that: (i) a meaningful context for policy space must extend beyond trade policy and include macroeconomic and exchange-rate policies that will achieve developmental goals more effectively; (ii) policy space depends not only on international rules but also on the impact of international market conditions and policy decisions taken in other countries on the effectiveness of national policy instruments; and (iii) international integration affects policy space through several factors that pull in opposite directions; whether it increases or reduces policy space differs by country and type of integration.
And Justice for All: An Alternative Decision to Williams v. Nassau County Medical Center to Ameliorate the Harsh Impact of New York’s Late Notice of Claim Statute on Infant Medical Malpractice Plaintiffs
No full textMayer, David A.; McGrath, Christopher. (2011). And Justice for All: An Alternative Decision to Williams v. Nassau County Medical Center to Ameliorate the Harsh Impact of New York’s Late Notice of Claim Statute on Infant Medical Malpractice Plaintiffs. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/155799
The Roman Inquisition : A Papal Bureaucracy and Its Laws in the Age of Galileo /
No full textAs Thomas F. Mayer demonstrates in this first study of the Roman Inquisition as an institution, the Inquisition underwent constant modification as it expanded. Originally aimed to eradicate Protestant heresy, it went beyond medieval antecedents by becoming a highly articulated centralized organ directly dependent on the pope.As Thomas F. Mayer demonstrates in this first study of the Roman Inquisition as an institution, the Inquisition underwent constant modification as it expanded. Originally aimed to eradicate Protestant heresy, it went beyond medieval antecedents by becoming a highly articulated centralized organ directly dependent on the pope.Electronic reproduction. ,Mode of access: Internet via World Wide Web.Thomas F. Mayer is Professor of History at Augustana College. He is author of Reginald Pole: Prince and Prophet, and editor and translator of The Trial of Galileo, 1612-1633.Description based on online resource; title from PDF title page (publisher’s Web site, viewed March 24, 2015
Rezension | Marianne Koos: Haut, Farbe und Medialität. Oberfläche im Werk von Jean-Étienne Liotard (1702–1789) + Christopher Baker/William Hauptman/Mary Anne Stevens (Hg.): Jean-Etienne Liotard, Kat. Ausst.
No full textMarianne Koos: Haut, Farbe und Medialität. Oberfläche im Werk von Jean-Étienne Liotard (1702–1789), Paderborn: Wilhelm Fink Verlag 2014, 440 S., ISBN 978-3-7705-5687-8. Christopher Baker/William Hauptman/Mary Anne Stevens (Hg.): Jean-Etienne Liotard, Kat. Ausst. (Scottish National Gallery, Edinburgh 2015; Royal Academy, London 2015/6), London 2015, 224 S., ISBN: 978-1-907533-99-0. Gernot Mayer (Wien) Die Ausstellung zu Jean-Étienne Liotard (1702–1789), die unlängst in der Scottish National Ga..
AN OVERVIEW OF MAJOR SOURCES OF DATA AND ANALYSES RELATING TO PHYSICAL FUNDAMENTALS IN INTERNATIONAL COMMODITY MARKETS
No full textThe debate on whether price movements in commodity markets are determined by changes in physical supply and demand fundamentals or by the speculative effects of financial investors seems to find some element of agreement on one particular point: the need for increased transparency and improved information on futures markets and physical commodity markets. This discussion paper provides an assessment of the current situation with regard to availability of information on physical commodity markets, pointing to some of the existing information gaps and areas for improvement. The paper presents a comprehensive account of the different information sources for physical commodity markets (including their websites), and could therefore be considered a practical information tool in itself, of use to different stakeholders interested in knowing about developments in these markets.
- …
