321 research outputs found
Portrait of Fred Hilmer [transparency] /
No full textCondition: Good.; Title supplied by artist, see acquisition file number 204/08/00063-02.; Part of the collection of photographs of portraits of prominent Australians. "Fred Hilmer (& Prof Lex Donaldson), Prof, associate dean author of the Hilmer Report, AGSM, University of New South Wales."--Note from artist
Portrait of Helen Hughes [transparency] /
No full textCondition: Good.; Title supplied by artist, see acquisition file number 204/08/00063-02.; Part of the collection of photographs of portraits of prominent Australians. Emeritus Professor of Economics Helen Hughes AO joined the CIS staff as a Senior Fellow in April 1998. Helen has had a long association with the Centre, and is co-author of the CIS Monographs Australias Asian Challenge and Working Youth. Helen has worked at the University of New South Wales, the University of Queensland and the World Bank before taking the position of Professor of Economics at the Australian National University in 1983. She was also Director of the National Centre for Development Studies, and presented the Boyer Lectures in 1985
Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress
No full textIn yeast as in human, DNA helicases play critical roles in assisting replication fork progression. The Saccharomyces cerevisiae MPH1 gene, homologue of human FANCM, has been involved in homologous recombination and DNA repair. We describe a synthetic growth defect of an mph1 deletion if combined with an srs2 deletion that can result - depending on the genetic background - in synthetic lethality. The lethality is suppressed by mutations in homologous recombination (rad51, rad52, rad55, rad57) and in the DNA damage checkpoint (rad9, rad24, rad17). Importantly, rad54 and mph1, epistatic for damage sensitivity, are subadditive for spontaneous mutator phenotype. Therefore, Mph1 could be placed at the Rad51-mediated strand invasion process, with a function distinct from Rad54. Moreover, siz1 mutation is viable with mph1 and additive for DNA damage sensitivity. mph1 srs2 double mutants, isolated in a background where they are viable, are synergistically sensitive to DNA damage. Moderate overexpression of SGS1 partially suppresses this sensitivity. Finally, we observe an epistatic relationship in terms of sensitivity to camptothecin of mms4 or mus81 to mph1. Overall, our results support a role of Mph1 in assisting replication progression. We propose two models for the resumption of DNA synthesis under replicative stress where Mph1 is placed at the sister chromatid interaction step. Copyright (C) 2009 John Wiley & Sons, Ltd
Budding yeast Mph1 promotes sister chromatid interactions by a mechanism involving strand invasion
No full textStalling of replication forks at lesions is a serious threat to genomic integrity and cell viability. Cells have developed a variety of pathways that allow continuation of synthesis, including translesion synthesis, postreplication repair and homologous recombination. We have devised a sensitive genetic system for detection of sister chromatid interactions in Saccharomyces cerevisiae. A 266 bp sequence duplication in the KanMX4 module was generated and reversions were scored via G418 resistant colonies. Both 4-NQO induced and spontaneous reversions are strictly dependent on RAD52. Damage-induced reversions are also largely dependent on RAD51. Thus, most damage-induced events require a strand invasion step. Induced reversions were not affected in rev3 mutants and partially reduced in rad30 mutants indicating an involvement of Pol eta. In cells lacking Mph1, a member of the FANCM family of DNA helicases, that has been implicated in a pathway for fork reactivation involving homologous recombination, damage-induced events are significantly reduced. Together with the spontaneous mutator phenotype of mph1 mutants this data strongly suggest that Mph1 has an additional function in recombination besides its previously described ability to disrupt D-loops. We propose that Mph1 promotes D-loop formation. (C) 2010 Elsevier B.V. All rights reserved.FAZIT-Stiftung; Studienstiftung des Deutschen Volkes; Leverhulme Trus
Eating disorder examination questionnaire (EDE-Q): psychometric properties and norms for the Portuguese population
No full textObjectiveThe first aim of the current study was to establish general population norms for the Portuguese version of the Eating Disorder Examination Questionnaire (EDE-Q) in a large community sample of female adolescents and young women, as well, for a diverse Eating Disorder (ED) clinical sample, and for women with obesity without an ED. A second aim of the study was to assess the discriminant validity of the EDE-Q and providing cut-off scores for the total scale and subscales.MethodA sample of female adolescents and young women (N=4091) from the general population, 416 women who met diagnostic criteria for an ED and 138 women seeking obesity treatment completed the EDE-Q.ResultsNorms for the EDE-Q global subscale were provided. Within the community sample, norms were provided for both high school and college samples. Receiver operating characteristic analysis showed that the EDE-Q total score accurately discriminate between participants with and without an ED. Current norm contributes to the clinical utility of the EDE-Q, providing both a cut-off score and reliable change index. Results showed that the EDE-Q is a reliable instrument, but the theorized four subscales structure was not supported by an explorative factor analysis.ConclusionResults will help both researchers and clinicians interpreting the EDE-Q scores and to establish comparison with data produced in different countries. Copyright (c) 2014 John Wiley & Sons, Ltd and Eating Disorders Association.FCT - Fundação para a Ciência e a Tecnologia()This research was partially supported by a Fundação para a Ciência e a Tecnologia (FCT) /Foundation for Science and Technology, Portugal research grant to the first author (PTDC/PSI-PCL/099981/2008.info:eu-repo/semantics/publishedVersio
sj-pdf-1-inc-10.1177_17511437221092685 – Supplemental Material for Building a Covid-19 secure intensive care unit: A human-centred design approach
No full textSupplemental Material, sj-pdf-1-inc-10.1177_17511437221092685 for Building a Covid-19 secure intensive care unit: A human-centred design approachl by Jody Ede, David Garry, Graham Barker, Owen Gustafson, Elizabeth King, Hannah Routley, Christopher Biggs, Cherry Lumley, Lyn Bennett, Stephanie Payne, Andrew Ellis, Clinton Green, Nathan Smith, Laura Vincent, Matthew Holdaway and Peter Watkinson in Journal of the Intensive Care Society</p
sj-pdf-2-inc-10.1177_17511437221092685 – Supplemental Material for Building a Covid-19 secure intensive care unit: A human-centred design approach
No full textSupplemental Material, sj-pdf-2-inc-10.1177_17511437221092685 for Building a Covid-19 secure intensive care unit: A human-centred design approachl by Jody Ede, David Garry, Graham Barker, Owen Gustafson, Elizabeth King, Hannah Routley, Christopher Biggs, Cherry Lumley, Lyn Bennett, Stephanie Payne, Andrew Ellis, Clinton Green, Nathan Smith, Laura Vincent, Matthew Holdaway and Peter Watkinson in Journal of the Intensive Care Society</p
Sowing in the autumn season : exploring benefits of green care farms for dementia patients
No full textIn the Netherlands an increasing number of farms combine agricultural production with care services for people with care needs. It is generally believed that these green care farms (GCFs) have beneficial effects on the health status of a diversity of target groups. At present, empirical studies testing this hypothesis are scarce. The main objective of the studies described in this thesis was to gain insight into the potential benefits of day care at GCFs for community‐dwelling older dementia patients. Day care at GCFs was therefore compared with day care at regular day care facilities (RDCFs). In view of the differences between both day care types regarding the day care setting and day care program it was hypothesized that they would differ in their effects on the health status of dementia patients. In two cross‐sectional studies it was tested to what extent the day program of dementia patients at GCFs differed from those at RDCFs. It appeared that at GCFs, dementia patients were (physically) more active, participated in more diverse activities, were more outdoors, and had more opportunities to perform activities in smaller groups than those at RDCFs. It was tested whether these differences resulted into different effects for five domains of health: dietary intake, cognition, emotional well‐being, behaviour, and functional performance. In a comparative cross‐sectional study dietary intake of dementia patients attending day care at GCFs or RDCFs was recorded both at home and during their time at the day care facility. The study showed that dementia patients attending day care at GCFs had significantly higher intakes of energy, carbohydrate, and fluid than their counterparts attending day care at RDCFs. In a cohort study, rates of change during 1 year in cognitive functioning, emotional well‐being, behavioural symptoms, and functional performance were compared between dementia patients attending day care at GCFs and RDCFs. Functioning in these domains remained rather stable and no differences were observed between subjects from GCFs and RDCFs. In the cohort study, also caregiver burden of family caregivers of these dementia patients was assessed. Caregivers’ quality of life, emotional distress, and feelings of competence remained rather stable in family caregivers of dementia patients from both day care settings. In conclusion, the present work has shown that GCFs exceeded RDCFs in offering older dementia patients a diverse day program and in stimulating their dietary intake. The latter may result into a better preserved nutritional status in dementia patients attending day care at GCFs than in those attending day care at RDCFs. GCFs and RDCFs were equally effective in preventing significant decrease of cognitive functioning, emotional well‐being, and functional performance and in preventing significant increase of the number of behavioural symptoms. Both day care types further prevented significant increase of caregiver burden. Day care at GCFs is a new and valuable addition to the present care modalities for community‐dwelling older dementia patients and their caregiver
Eating Disorder Examination-Questionnaire as a measure of change in patients with bulimia nervosa.
No full textOBJECTIVE: The current study evaluated the agreement between the Eating Disorder Examination and the Eating Disorder Examination-Questionnaire in assessing eating disorder pathology in a sample of women with bulimia nervosa. METHOD: Patients with broadly defined bulimia nervosa were enrolled in a double-blind, placebo-controlled treatment study of fluoxetine, with and without guided self-help. The current study presents information from 50 patients with data from both the EDE and EDE-Q at study entry and treatment termination. RESULTS: The EDE and EDE-Q produced more similar scores for compensatory behaviors (vomiting/laxative use) than complex eating-disordered features (binge eating/importance of shape and weight) at the pretreatment and posttreatment assessments, and for change during the study. DISCUSSION: The EDE and EDE-Q are highly correlated for many of the behavioral and attitudinal features of bulimia nervosa. There is substantial variability in agreement for individual patients, but on average, the EDE and EDE-Q will yield similar assessments of eating disorder symptoms and change in symptoms over time
EDE TERÉNYI IS 80 YEARS OLD. A LIFE SERVING ART, TEACHING AND THE MUSICAL SCIENCES
No full textAuthor of several hundred musical works, Ede Terényi (b. 1935) is a weighty and original personality within the cultural life of Transylvania. Composing did not mean to him merely a process of artistic creation based on incidental mathematical formulas. His entire being is continuously living within and through music. Music is the meaning of his life, his motivation for existence. He is a man with great sensitivity who lets himself be inspired by a word, an image, a gesture, a verse or a wonderful piece of music he has just heard. His works have been created by spontaneous inspiration, on the one hand and by a steady, conscious work on fine tuning his music, everything that belongs to the so called craftsmanship in composing, on the other
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