49 research outputs found
When the Others Become Us: A Chemist’s Perspective of the COVID-19 Outbreak in Italy
No full textThe spread of COVID-19 has been declared a pandemic, and we as a global community are watching as hot spots of this illness emerge across not only countries but continents. As the situation has progressed, the focus of scientists and their ability to undertake most experiments has been limited to facilitating physical distancing. Still, research addressing varied aspects of diagnosing, treating, and mitigating the spread of COVID-19 is not only continuing but accelerating with the goal of reducing loss of life. Chemical biologists have integral contributions to make: Chemical tools can address challenges in biology, which is what is required to understand and mitigate SARS-CoV-2. Given that Italy is now under tremendous stress from COVID-19, we asked an Italian scientist to discuss the strategies that academic and industrial laboratories in Italy are pursuing to limit the impact of the virus both on their research and on society. We hope that this perspective along with that of our Chinese colleagues will provide insight into the important scientific advancements and the human aspects of advancing science in the face of a rapidly growing pandemic
Profile of author and Portland native Heidi Julavits, featuring an interview in
No full textProfile of author and Portland native Heidi Julavits, featuring an interview in question-and-answer format. Julavits\u27s third novel, The Uses of Enchantment, is about a 17-year-old girl in West Salem, Mass., who may or may not have faked her own abduction. In addition to fiction writing, Julavits is founding editor of the Believer magazine. Julavits splits her time between Manhattan and Brooklin, Maine
Introducing the 2023 Bioconjugate Chemistry Editorial Team
No full textAlong with the celebration of the new year, we celebrate many successes at Bioconjugate Chemistry. This includes additions and renewal of our editors, who play a critical role in service to our research community of authors, reviewers, and readers. As highlighted in our January 2023 editorial, (1) we sincerely thank Prof. Vince Rotello, who stepped down after a decade of success as Editor-in-Chief. We also extend a sincere thank you to Prof. Bradley Smith, who also stepped down after 10 years of service as Associate Editor for the journal. With great enthusiasm, we introduce the 2023 editorial team at Bioconjugate Chemistry, which includes five new additions to the editorial staff: Prof. Gonçalo Bernardes from the University of Cambridge, Prof. Peng Zou, from the Peking University, Mr. Nathan Quinn and Dr. Christina MacLaughlin from ACS Publications, and Prof. Theresa Reineke from the University of Minnesota. We also introduce and celebrate the team of four editors that are continuing in dedicated service to our community and ACS Publications: Prof. Zhifei Dai from Peking University, Prof. Jan van Hest from Eindhoven University of Technology, Prof. Erin Lavik from the University of Maryland Baltimore Country, and Prof. Gang Zheng from the University of Toronto. We wish our entire scientific community a happy, healthy, and productive 2023 and look forward to working with you all to disseminate many exciting advances in Bioconjugate Chemistry
Surface Enhanced Raman Scattering Nanoparticles as Optical Labels for Imaging Cell Surface Proteins
No full textAssaying the expression of cell surface proteins has widespread application for characterizing cell type, developmental stage, and monitoring disease transformation. Immunophenotyping is conducted by treating cells with labelled targeting moieties that have high affinity for relevant surface protein(s). The sensitivity and specificity of immunophenotyping is defined by the choice of contrast agent and therefore, the number of resolvable signals that can be used to simultaneously label cells. Narrow band width surface-enhanced Raman scattering (SERS) nanoparticles are proposed as optical labels for multiplexed immunophenotying.
Two types of surface coatings were investigated to passivate the gold nanoparticles, incorporate SERS functionality, and to facilitate attachment of targeting antibodies. Thiolated poly(ethylene glycol) forms dative bonds with the gold surface and is compatible with multiple physisorbed Raman-active reporter molecules. Ternary lipid bilayers are used to encapsulate the gold nanoparticles particles, and incorporate three different classes of Raman reporters. TEM, UV-Visible absorbance spectroscopy, DLS, and electrophoretic light scattering were used characterize the particle coating. Colourimetric protein assay, and secondary antibody labelling were used to quantify the antibody conjugation.
Three differentPh.D.2016-11-16 00:00:0
Role for Standardization in Electrocatalytic Ammonia Synthesis: A Conversation with Leo Liu, Lauren Greenlee, and Douglas MacFarlane
No full textSurface Enhanced Raman Scattering Nanoparticles as Optical Labels for Imaging Cell Surface Proteins
No full textAssaying the expression of cell surface proteins has widespread application for characterizing cell type, developmental stage, and monitoring disease transformation. Immunophenotyping is conducted by treating cells with labelled targeting moieties that have high affinity for relevant surface protein(s). The sensitivity and specificity of immunophenotyping is defined by the choice of contrast agent and therefore, the number of resolvable signals that can be used to simultaneously label cells. Narrow band width surface-enhanced Raman scattering (SERS) nanoparticles are proposed as optical labels for multiplexed immunophenotying.
Two types of surface coatings were investigated to passivate the gold nanoparticles, incorporate SERS functionality, and to facilitate attachment of targeting antibodies. Thiolated poly(ethylene glycol) forms dative bonds with the gold surface and is compatible with multiple physisorbed Raman-active reporter molecules. Ternary lipid bilayers are used to encapsulate the gold nanoparticles particles, and incorporate three different classes of Raman reporters. TEM, UV-Visible absorbance spectroscopy, DLS, and electrophoretic light scattering were used characterize the particle coating. Colourimetric protein assay, and secondary antibody labelling were used to quantify the antibody conjugation.
Three differentPh.D.2016-11-16 00:00:0
Opportunities and Challenges in Perovskite-Based Display Technologies: A Conversation with Andrey Rogach and Haibo Zeng
No full textInnovations in Lithium Ion Battery Technologies: A Conversation with Will West, Nancy Dudney, and Andrew Westover
No full textWH-movement in ASL: A modern analysis of leftward vs. rightward movement
No full text[ABSTRACT ONLY; NO FULL TEXT] This paper seeks to address a continuing debate over the direction of movement of WH-questions in the syntax of American Sign Language (ASL). Various sources have contributed to this discussion, but this paper focuses on the arguments of two main parties. They are Petronio and Lillo-Martin (1997), and Neidle, MacLaughlin, Lee, Bahan, and Kegl (1998). The former group argues that WH-questions ('who, what, when, where, why' and 'how') move to a leftward specifier of the clause phrase (Spec-CP) while the latter argues in favor of movement to a rightward Spec-CP. This conflict in stances is the issue addressed in this paper. After a primer of the mechanisms of ASL both sides are summarized to introduce the leftward/rightward debate. A feature of language is that it is always changing, and as such the structure of ASL may have changed since the emergence of these two papers, calling for a need of further, more recent data. In this way, this paper contributes to the discussion of WH-movement in ASL; data was collected from current users of ASL to help determine whether WH-questions are moved to a leftward Spec-CP in the syntax or to a rightward one. The data uncovered with this study contributes to the field of linguistics in the way that it provides a modern take on ASL syntax, and also contributes to how we as a society view ASL
