1,721,002 research outputs found
Genetic Testing
No full textThe transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2003.©The Trustee of the Wellcome Trust, London, 2003.All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a meeting held on 13 July 2001. Introduction by Professor Peter Harper.Annotated and edited transcript of a meeting held on 13 July 2001. Introduction by Professor Peter Harper.Annotated and edited transcript of a meeting held on 13 July 2001. Introduction by Professor Peter Harper.Annotated and edited transcript of a meeting held on 13 July 2001. Introduction by Professor Peter Harper.Annotated and edited transcript of a meeting held on 13 July 2001. Introduction by Professor Peter Harper.Annotated and edited transcript of a meeting held on 13 July 2001. Introduction by Professor Peter Harper.Remarkable strides were made in the twentieth century in understanding the basis of heredity and in deciphering how the genes, the units of heredity, function. Chaired by Professor Marcus Pembrey, and attended by a group of leading experts in the field at the time, this Witness Seminar discussed the development of genetic testing to identify chromosomal and gene variations associated with health problems. The seminar also examined the contributions of research by UK laboratories that provided keys to the development of genetic medicine and use of genetic testing in clinical practice. Participants discussed specific areas of research such as cytogenetics, linkage analysis and DNA testing, biochemical genetics, prenatal screening and testing, preimplantation diagnosis, and immunogenetics and blood groups. Christie D A, Tansey E M. (eds) (2003) Genetic testing, Wellcome Witnesses to Twentieth Century Medicine, vol. 17. London: Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
Maternal Care
No full textThis is the edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 6 June 2000. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2001.©The Trustee of the Wellcome Trust, London, 2001. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 6 June 2000. Introduction by Dr Hilary Marland, University of Warwick.Annotated and edited transcript of a Witness Seminar held on 6 June 2000. Introduction by Dr Hilary Marland, University of Warwick.Annotated and edited transcript of a Witness Seminar held on 6 June 2000. Introduction by Dr Hilary Marland, University of Warwick.Annotated and edited transcript of a Witness Seminar held on 6 June 2000. Introduction by Dr Hilary Marland, University of Warwick.In June 2000 a distinguished group of obstetricians, midwives, general practitioners, and medical statisticians came together to discuss maternal care. Chaired by Professor James Drife from Leeds, discussion ranged over many topics, including: the changing role of the obstetrician, general practitioners, and the increasing status and responsibility of midwives. Other subjects include the induction of labour, obstetric analgesia and anaesthesia, and debates about the place and kind of delivery that women wanted. Among those who attended and contributed were: Ms Beverley Beech, Dr Michael Bull, Sir Iain Chalmers, Professor Geoffrey Chamberlain, Ms Mary Cronk, Professor Peter Dunn, Ms Chloe Fisher, Mrs Caroline Flint, Ms Rosemary Jenkins, Dr Irvine Loudon, Professor Alison Macfarlane, Professor Lesley Page, Mr Roger Peel, Mr Elliot Philipp, Mrs Wendy Savage, Mrs Vicky Tinsley, Dame Margaret Wheeler and Professor Charles Whitfield. Christie D A, Tansey E M. (eds) (2001) Maternal care, Wellcome Witnesses to Twentieth Century Medicine, vol. 12. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
Intestinal Absorption
No full textThis is the edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine,in London, on 9 February 1999. First published by the Wellcome Trust, 2000. ©The Trustee of the Wellcome Trust, London, 2000.All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edtied transcript of a Witness Seminar held on 9 February 1999. Introduction by Sir Christopher Booth.Annotated and edtied transcript of a Witness Seminar held on 9 February 1999. Introduction by Sir Christopher Booth.Annotated and edtied transcript of a Witness Seminar held on 9 February 1999. Introduction by Sir Christopher Booth.Annotated and edtied transcript of a Witness Seminar held on 9 February 1999. Introduction by Sir Christopher Booth.A record of a meeting chaired by Lord Turnberg that brought together those from laboratory research and medical practice to discuss some of the key aspects of intestinal absorption, including work on basic physiological mechanisms and techniques, such as the discovery of dedicated transport systems and their localization, and their clinical impact in intestinal disorders and oral rehydration therapy. Participants include: Sir Christopher Booth, Dr Richard Boyd, Professor Ramsey Bronk, Professor Hermon Dowling, Professor Michael Gardner, Dr Michael Hellier, Dr Roy Levin, Professor Richard Naftalin, Professor Timothy Peters, Professor John Walker-Smith and Professor Oliver Wrong. Christie D A, Tansey E M. (eds) (2000) Intestinal absorption, Wellcome Witnesses to Twentieth Century Medicine, vol. 8. London: The Wellcome Trust.The Wellcome Trust is a registered charity, no. 210183
Looking at the Unborn: Historical aspects of obstetric ultrasound
No full textEdited trascript of a Witness Seminar held at the Wellcome Institute for the History of Medicine,in London, on 10 March 1998. First published by the Wellcome Trust, 2000. ©The Trustee of the Wellcome Trust, London, 2000. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 10 March 1998. Introduction by E M Tansey.Annotated and edited transcript of a Witness Seminar held on 10 March 1998. Introduction by E M Tansey.Annotated and edited transcript of a Witness Seminar held on 10 March 1998. Introduction by E M Tansey.Annotated and edited transcript of a Witness Seminar held on 10 March 1998. Introduction by E M Tansey.The obstetric ultrasound scanner had its major origins in a programme of research undertaken in Glasgow in the 1950s and 1960s, under the leadership of the obstetrician, Professor Ian Donald. Donald’s work was characterized by a remarkable series of collaborations between engineers and clinicians, many of whom took part in this Witness Seminar to consider the early history of ultrasound imaging, its technical development and significant clinical applications in the diagnosis of fetal abnormalities. Technical and engineering developments of the scanner were discussed and it was practical demonstrations of the early scanners that gradually convinced the majority of obstetricians to invest time and training in this new technology. Participants include: Mr Usama Abdulla, Mr Thomas Brown, Professor Dugald Cameron, Professor Stuart Campbell, Mr John Fleming, Professor John MacVicar, Professor Peter Wells and Dr James Willocks. Tansey E M, Christie D A. (eds) (2000) Looking at the unborn: Historical aspects of obstetric ultrasound, Wellcome Witnesses to Twentieth Century Medicine, vol. 5. London: The Wellcome Trust.The Wellcome Trust is a registered charity, no. 210183
Origins of Neonatal Intensive Care
No full textThis is the edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine,London, on 27 April 1999. First published by the Wellcome Trust Centre
for the History of Medicine at UCL, 2001.©The Trustee of the Wellcome Trust, London, 2001.All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 27 April 1999. Introduction by Professor Peter Dunn.Annotated and edited transcript of a Witness Seminar held on 27 April 1999. Introduction by Professor Peter Dunn.Annotated and edited transcript of a Witness Seminar held on 27 April 1999. Introduction by Professor Peter Dunn.Annotated and edited transcript of a Witness Seminar held on 27 April 1999. Introduction by Professor Peter Dunn.Chaired by Professor Robert Boyd, this seminar reviewed the development and changes in care of the newborn in the UK over the past 50 years. Advances in techniques were described, such as mechanical ventilation, total parenteral nutrition and continuous monitoring of vital signs, to care for ill or vulnerable newborn infnts. Diagnostic techniques that were developed and introduced in the 1970s and early 1980s were discussed, such as ultrasound imaging, magnetic resonance spectroscopy and imaging and near infrared spectroscopy, for the non-invasive investigation of the brain, as well as the setting up of neonatal intensive care units. Witnesses include: Professor Eva Alberman, Dr Herbert Barrie, Professor Richard Cooke, Dr Beryl Corner, Dr Pamela Davies, Professor John Davis, Professor David Delpy, Professor Victor and Dr Lilly Dubowitz, the late Professor Harold Gamsu, Professor David Harvey, Professor Colin Normand, Professor Tom Oppé, Professor Osmund Reynolds, Dr Jean Smellie, Professor Maureen Young and nurses, including Miss Anthea Blake, Miss Caroline Dux and Miss Mae Nugent. Christie D A, Tansey E M. (eds) (2001) Origins of neonatal intensive care, Wellcome Witnesses to Twentieth Century Medicine, vol. 9. London: The Wellcome Trust Centre for the History of Medicine at UCL. IBSN 978 085484 0762The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
Development of Physics Applied to Medicine in the UK, 1945–90
No full textAnnotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2006.©The Trustee of the Wellcome Trust, London, 2006.All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.Annotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.Annotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.Annotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.Annotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.Annotated and edited transcript of a Witness Seminar held on 5 July 2005. Introduction by Dr Jeff Hughes.Organized with the assistance of Professor John Clifton (UCL) and chaired by Professor Peter Williams (Manchester), this seminar examined the early developments of medical physics in the UK between 1945 and 1990. Participants discussed a range of themes including medical physics before and during the war, the role of the King's Fund and the formation of the Hospital Physicists' Association (HPA), expansion of medical physics outside radiotherapy and to non-radiation physics (ultrasound, medical instrumentation, bioengineering, use of digital computers), developing regional services and links with industry. The seminar finished with a discussion on the changing scene in the 1980s, covering topics such as funding, academic and undergraduate medical physics, imaging, CT, NMR and others. Participants included Mr Tom Ashton, Dr Barry Barber, Professors Roland Blackwell and Terence Burlin, Dr Joseph Blau, Mr Bob (John) Burns, Professors John Clifton, David Delpy, Philip Dendy and Jack Fowler, Dr Jean Guy, Mr John Haggith, Drs John Haybittle, Alan Jennings and John Law, Professors John Mallard and Joe McKie, Mr David Murnaghan, Professor Angela Newing, Dr Sydney Osborn, Professor Rodney Smallwood, Dr Adrian Thomas, Dr Peter Tothill, Mr Theodore Tulley, Professors Peter Wells and John West, and Mr John Wilkinson. Christie D A, Tansey E M. (eds) (2006) Development of physics applied to medicine in the UK, 1945–90, Wellcome Witnesses to Twentieth Century Medicine, vol. 28. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
Cystic Fibrosis
No full textFirst published by the Wellcome Trust Centre
for the History of Medicine at UCL, 2004. ©The Trustee of the Wellcome Trust, London, 2004. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 11 June 2002. Introduction by Professor John Dodge.Annotated and edited transcript of a Witness Seminar held on 11 June 2002. Introduction by Professor John Dodge.Annotated and edited transcript of a Witness Seminar held on 11 June 2002. Introduction by Professor John Dodge.Annotated and edited transcript of a Witness Seminar held on 11 June 2002. Introduction by Professor John Dodge.Annotated and edited transcript of a Witness Seminar held on 11 June 2002. Introduction by Professor John Dodge.Annotated and edited transcript of a Witness Seminar held on 11 June 2002. Introduction by Professor John Dodge.In the 1930s, when cystic fibrosis (CF) was first clearly recognised, it was a disorder that inevitably led to death in early childhood from respiratory failure and malnutrition. Since that time, antibiotic treatment and improving nutrition have brought increasing hope to sufferers from the disorder, so that increasing numbers of children have lived on into adult life. Chaired by Professor John Walker-Smith, and attended by a group of leading experts in field at the time, this transcript discusses the history and development of treatment as a result of the establishment of multidisciplinary teams working at special CF centres. Participants also discussed the role of the Cystic Fibrosis Trust and the identification in 1989 of the defective gene, which made antenatal diagnosis possible and suggests that gene therapy might become feasible in the future. Christie D A, Tansey E M. (eds) (2004) Cystic fibrosis, Wellcome Witnesses to Twentieth Century Medicine, vol. 20. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at University College London is funded by the Wellcome Trust,which is a registered charity, no. 210183
Peptic Ulcer: Rise and fall
No full textConsists of the edited transcripts of Witness Seminars organized by the History of Twentieth Century Medicine Group and held at the Wellcome Institute for the History of Medicine,London, on 12 May 2000. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2002.©The Trustee of the Wellcome Trust, London, 2002. All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on xx. Introduction by Sir Christopher Booth.Annotated and edited transcript of a Witness Seminar held on xx. Introduction by Sir Christopher Booth.Annotated and edited transcript of a Witness Seminar held on xx. Introduction by Sir Christopher Booth.Annotated and edited transcript of a Witness Seminar held on xx. Introduction by Sir Christopher Booth.Annotated and edited transcript of a Witness Seminar held on xx. Introduction by Sir Christopher Booth.Annotated and edited transcript of a Witness Seminar held on xx. Introduction by Sir Christopher Booth.In May 2000, a distinguished group of scientists and clinicians came together in a one-day meeting to discuss the recent history of peptic ulcer, and its rise and fall. Chaired by Professor Roy Pounder from the Royal Free Hospital, witnesses described their personal experiences, and events that have affected the understanding, diagnosis and treatment of peptic ulcer through the twentieth century. This volume includes an account by Nobel Prize Winner, Sir James Black, of the introduction in the 1970s of the H2 receptor antagonists which added a new dimension to treatment of peptic ulcer disease, and also considers the discovery by Barry Marshall and colleagues of Helicobacter pylori as a causative factor in duodenal and gastric ulcers, which opened up new opportunities in the management of gastrointestinal disorders. Aetiology, therapeutic clinical trials, surgical procedures and advances in gastrointestinal endoscopy are also discussed. Among those who contributed were: Dr John Atherton, Dr Hugh Baron, Sir James Black, Dr Joseph N Blau, Sir Christopher Booth, Mr Roger Celestin, the late Dr Nelson Coghill, Dr Gerard Crean, Dr Booth Danesh, Professor Graham Dockray, Sir Richard Doll, Dr Peter Down, Sir Patrick Forrest, Professor Stewart Goodwin, Dr Jean Guy, Professor Michael Hobsley, Dr Peter Hunter, Dr Belinda Johnston, Professor Roger Jones, Mr Raymond Kirk, Professor Michael Langman, Professor John Lennard-Jones, Dr Robert Logan, Professor Kenneth McColl, Dr George Misiewicz, Professor Timothy Northfield, Professor Colm Ó’Moráin, Dr John Paulley, Professor Robert Steiner, Mr Frank Tovey, Dr David Tyrrell and Dr John Wood. Christie D A, Tansey E M. (eds) (2002) Peptic Ulcer: Rise and fall, Wellcome Witnesses to Twentieth Century Medicine, vol. 14. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
Short-Course Chemotherapy for Tuberculosis
No full textAnnotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2005. ©The Trustee of the Wellcome Trust, London, 2005. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.The introduction in 1952 of isoniazid established the standard treatment of streptomycin, isoniazid and either thiacetazone or para-aminosalicylic acid for pulmonary tuberculosis. To achieve good results, patients had to take treatment for 18 or even 24 months under supervision. By 1970 a move towards short-course chemotherapy was made, in part due to experimental work in mice at the Pasteur Institute (Paris) and in part to experiments in Professor Denny Mitchison's unit at the Hammersmith Hospital, along with the advent of rifampicin and reappraisal of pyrazinamide. Finally, a series of large controlled clinical trials were carried out by the MRC in East and Central Africa, India, Singapore, Hong Kong and elsewhere. The trials showed that a remarkable and quite unpredictable simplification of treatment could be made with a cost-benefit of major importance. Chaired by Dr David Girling this Witness Seminar brought together a group of experts who were involved in some of the major developments in the treatment of tuberculosis and included: Dr Joseph Angel, Dr Ian Campbell, Sir Iain Chalmers, Dr Kenneth Citron, Sir John Crofton, Professor Janet Darbyshire, Professor Alan Glynn, Dr Tony Jenkins, Dr Amina Jindani, Dr Jeanette Meadway, Professor Dennis Mitchison, Dr John Moore-Gillon, Professor Andrew Nunn, Professor Peter Ormerod and Dr Knut Øvreberg. Mrs Gaye Fox attended on behalf of Professor Wallace Fox. Christie D A, Tansey E M. (eds) (2005) Short-course chemotherapy for tuberculosis, Wellcome Witnesses to Twentieth Century Medicine, vol. 24. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at University College London is funded by the Wellcome Trust,which is a registered charity, no. 210183
Leukemia
No full textThe transcript of a Witness Seminar held at the Wellcome Trust Centre for the History of Medicine at UCL, London, on 15 May 2001.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2003.©The Trustee of the Wellcome Trust, London, 2003. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 15 May 2001. Introduction by Professor Sir David Weatherall, Institute of Molecular Medicine, Oxford.Annotated and edited transcript of a Witness Seminar held on 15 May 2001. Introduction by Professor Sir David Weatherall, Institute of Molecular Medicine, Oxford.Annotated and edited transcript of a Witness Seminar held on 15 May 2001. Introduction by Professor Sir David Weatherall, Institute of Molecular Medicine, Oxford.Annotated and edited transcript of a Witness Seminar held on 15 May 2001. Introduction by Professor Sir David Weatherall, Institute of Molecular Medicine, Oxford.Annotated and edited transcript of a Witness Seminar held on 15 May 2001. Introduction by Professor Sir David Weatherall, Institute of Molecular Medicine, Oxford.Annotated and edited transcript of a Witness Seminar held on 15 May 2001. Introduction by Professor Sir David Weatherall, Institute of Molecular Medicine, Oxford.This transcript examines some of the major discoveries and developments in the management of leukaemia over the past 30 years, such as the discovery of the alkylating agents (chlorambucil and busulphan) at London’s Chester Beatty Research Institute, exchange transfusion and the exciting development of combined chemotherapy (daunorubicin and cytosine arabinoside) that led to more than 60 per cent of adults with acute myelogenous leukaemia achieving complete remission. The introduction of clinical trials and issues related to funding were also discussed. Those who contributed included Professor Daniel Catovsky, Professor David Galton, Professor John Goldman (Chair), Professor Frank Hayhoe, Professor Victor Hoffbrand, Professor Humphrey Kay, Professor John Lilleyman, Professor Ian MacLennan, Dr Gordon Piller, Dr Rosemary Shannon, and Dr Eve Wiltshaw. Christie D A, Tansey E M. (eds) (2003) Leukaemia, Wellcome Witnesses to Twentieth Century Medicine, vol. 15. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
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