2,680 research outputs found
Art Monthly Talk Show on Resonance FM
No full textTalk Show on Resonance FM
Emily Rosamond, Juliet Jacques & Lucia Farinati
Presented by Chris McCormack
Emily Rosamond discusses online reputation warfare, Juliet Jacques reports on Manifesta 14 in Prishtina and Lucia Farinati reviews a show by Italian feminist artist group Le Nemesiache
John Bird and Peter Scott, with students Chris Drewnicki and Jon McCormack using computer, 1985
No full textSwinburne lecturer Mr John Bird and Mr Peter Scott, Pyramid Technology (Australia), with students Chris Drewnicki and Jon McCormack using computer, 1985. Photograph originally appeared in 'Swinburne Limited Newsletter', 18 July 1985 (p. 1)
Diagramming movement between the cartographic and the choreographic: research report
No full text"Diagramming Movement between the Cartographic and the Choreographic" was an experimental interdisciplinary research project, which in part was concerned with exploring a collaborative research methodology that had a heterarchical structure. Undertaken with geographer Dr Derek McCormack, from Oxford Univerrsity, PhD students and independent artists the project was strand of a larger research project, "Society of Molecules" run by the Senselab, a Research Centre with a global reach that was initiated by Dr Erin Manning of Concordia University, Montreal, and involved researchers from all over the world. "Society of Molecules" employed a global distributive participatory research model, which we echoed at a smaller scale in our UK 'molecule'. Each international molecule was invited to initiate aesthetico-political interventions. The theme that guided our research was the diagramming of movement between the cartographic and the choreographic, using Deleuzian-induced understandings of the cartographic, and introducing the notions of affect that emerged in Deleuze and Guattari's work. The research involved practice-based experimentations/interventions alongside readings of the work of geographers, philosophers and other theorists whose work addressed issues consonant with our concerns, conceptual traces of which could be detected in the practical results of the research experiment. The above are all described and reflected upon in this research report
Portrait of John W. McCormack, Speaker of the House of Representatives.
No full textHandwritten inscription: \u27To Felton M. Johnston, my dearly valued friend with the respect and friendship of [John W. McCormack]\u27https://egrove.olemiss.edu/fmjohnston/1113/thumbnail.jp
Today's lifestyles, tomorrow's cancers: Trends in lifestyle risk factors for cancer in low- and middle-income countries
No full textBackground: The global burden of cancer is projected to increase from 13.3 to 21.4 million incident cases between 2010 and 2030 due to demographic changes alone, dominated by a growing burden in low- and middle-income countries (LMICs). Lifestyle risk factors for cancer are also changing in these countries and may further influence this burden.Design: We consider examples of changes already occurring in population-level distributions of tobacco and alcohol consumption, body weight, and reproductive lives of women to gauge the magnitude of their projected impact on cancer incidence in future decades.Results: Trends in lifestyle factors vary greatly between settings and by sex. Some common trends point to considerable increases in cancers of the (i) lung in men due to tobacco smoking; (ii) upper aerodigestive tract (UADT) due to increasing tobacco and alcohol consumption, worse in men; (iii) colon from increasing body mass index, and alcohol and tobacco consumption; and (iv) in women, breast due particularly to consistent international trends of younger age at menarche, smaller family size, and, at postmenopausal ages, increasing body weight.Conclusions: In many LMICs, the future cancer burden will be worsened by changing lifestyles. Affected common cancer sites likely to experience the largest increases are lung, colon, UADT, and breast. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved
Revisiting res ipsa loquitur: Mccormack v Sportsdirect.Com Fitness Limited considered
No full textIn this article, the author considers the recent decision of the Sheriff Appeal Court in Mccormack v Sportsdirect.Com Fitness Limited [2025] SAC (Civ) 15 in which the maxim res ipsa loquitur was found to have been incorrectly applied by the sheriff court.<br/
Author response
No full textPerforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria. We show here that a cullin-RING E3 ubiquitin ligase (CRL) complex containing cullin-1 and βTrCP monoubiquitylates Perforin-2 in response to pathogen associated molecular patterns such as LPS. Ubiquitylation triggers a rapid redistribution of Perforin-2 and is essential for its bactericidal activity. Enteric pathogens such as
Yersinia pseudotuberculosis
and enteropathogenic
Escherichia coli
disarm host cells by injecting cell cycle inhibiting factors (Cifs) into mammalian cells to deamidate the ubiquitin-like protein NEDD8. Because CRL activity is dependent upon NEDD8, Cif blocks ubiquitin dependent trafficking of Perforin-2 and thus, its bactericidal activity. Collectively, these studies further underscore the biological significance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria.
DOI:
http://dx.doi.org/10.7554/eLife.06505.001
A wide range of bacteria and other microbes can infect animals and cause disease. Throughout evolution, these microbes and their hosts have been fighting never ending arms races in which the microbes deploy ever more elaborate weapons, while the hosts adapt to defend themselves. An animal's first line of defense is provided by its ‘innate’ immune system. This system is activated by the general features of microbial cells; for example, the molecules that make up the walls surrounding most bacteria. Microbes must defeat the innate immune system in order to cause disease, and ultimately to spread from one host to the next.
One component of innate immunity is a protein called Perforin-2 that is present in most, if not all, animal cells. This protein forms pores on bacterial cells, causing them to split open and die. However, it was not clear how Perforin-2 is switched on and what, if anything, bacteria do to counteract it. To address these questions, McCormack et al. infected human and mice cells with bacteria that cause serious diseases of the digestive tract.
The experiments show that when animal cells detect bacteria, or merely a fragment of their cell wall, a specific group of proteins, called the CRL complex, attaches a molecule called ubiquitin to Perforin-2. Ubiquitin works much like the shipping label of a package, enabling the efficient targeting of Perforin-2 to the invading bacteria. McCormack et al. also show that some bacteria use a protein called a cell cycle inhibiting factor (or Cif for short) to inhibit the CRL complex. This blocks the ubiquitin labeling of Perforin-2, which renders it a useless weapon that can no longer be directed towards bacteria.
Mice that are infected with a bacterium called
Yersinia pseudotuberculosis
become seriously unwell and often die. However, McCormack et al. found that mice infected with mutant
Y. pseudotuberculosis
that lacked Cif remained healthy. Also, mice that lacked Perforin-2 are highly susceptible to infectious diseases. McCormack et al.'s findings reveal how Perforin-2 is activated during the innate immune response and how some bacteria can defeat this pivotal defense. In the current age of antibiotic resistant bacteria, these studies may spur the development of new drugs that restore or increase the activity of Perforin-2.
DOI:
http://dx.doi.org/10.7554/eLife.06505.00
Review of George Eliot in Society: Travels Abroad and Sundays at the Priory
No full textThis is a welcome and wholly worthwhile extension of the author\u27s George Eliot\u27s English Travels: Composite Characters and Coded Communication (2005), a densely written and stimulating examination of places and people in Eliot\u27s life which have some resonance, in varying degrees of coding, from the seemingly casual to the subtly integrated, in her published work. McCormack there defined three categories of place identification. These range from \u27absolute certainties\u27 through \u27pretty good cases\u27 to \u27alluring, probable, but irretrievably speculative suppositions\u27, categories certainly applicable to herpresent study, in which her dedication and saturation in George Eliot, the works, the life, and a wide range of biographical and critical commentary, is again evident. It is a direct invitation to see and feel places and people, decode traits, pick up on similarities, mine differences, above all, be aware. McCormack\u27s method is one of intimate identification with the life and the writing life.
The main thrust demonstrates how Eliot\u27s social agenda, with the Sunday salons from 1869 onwards at the Priory as the focus, feeds into her fiction - and initially her poetry - together with comparable assimilations from her travelling life in Europe with Lewes from 1854 onwards up to the fraught honeymoon with Cross in 1880. Throughout, the Haight contention that Eliot was largely reclusive, a view commonly supported, is subjected to intense scrutiny and is vigorously disputed. The Sunday gatherings, carefully assembled, would suggest that Eliot enjoyed being the centre of a salon of her own making, her essay on Madame de Sable providing precursory evidence. The importance of Lewes as initiator, manager, socializing facilitator with an eye alert as always to publishing and critical opportunities, is integral. McCormack uses his unpublished journals and diaries, supplementing them with a detailed attention to known biographical sources which she carefully sifts for reliability or bias
‘…a tiny part of that greater circum-terrestrial grid’: A Conversation with Mike McCormack
No full textThis is the author accepted manuscript. The final version is available from Edinburgh University Press via the DOI in this recor
The Third Hand —Claire, Bernadette and Friends
No full textThis discussion between Chris McCormack, Helena Reckitt, and Gerrie van Noord, moderated by Lina Džuverović, focuses on the deliberately orchestrated erasures of individual identities that constitute new authorial entities. Touching on the collective projects of Claire Fontaine, Bernadette Corporation, Reena Spaulings, speakers explore how these authorial avatars function as engines of institutional critique that aim to free up polyvocal expression, critically engaging with institutional structures, from art fairs, to private galleries, classrooms and museums. Panellists also consider instances of activist projects such as The Guerilla Girls, Anonymous, The Clown Army, and Carrot Workers Collective, which are informed by the need to protect individual identities in order to enable effective action.
Drawing on the term ‘the third hand’ introduced by Charles Green in his eponymous book (2001), speakers discuss the divergent approaches and goals harboured by such strategies. The panel concludes by considering the 'invisible' collaborative work of editors, addressing the shifting boundaries of authorship, its gendered dimensions, and the intimacies developed through processes of editing as well as translation
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