2 research outputs found
CONSEQUENCES OF THE PROLIFERATION OF LUPUS NEPHRITIS
No full textBackground: Systemic lupus erythematosus (SLE) is a chronic, auto immune disorder and multisystem. This disease is non-predictable and its nature is episodic. Its severe complication includes Kidney inflation.
Material and Methods: For the research purpose 43 cases were short listed with an incidence of III/IV lupus nephritis. These patients visited OPDs and clinics from January, 2016 to October, 2017 with an additional 6-month follow-up. Nine of them were treated with mycophenolate and remaining thirty-four were treated with cyclophosphamide. At the end of six months’ proteinuria and glomerular estimation of filtration rate was administrated in the patients. Response was also calculated in the patients.
Results: Complete or partial response was observed in the 44 percent of the cases in the six months’ duration whereas 64 percent of the cases were noted for their response at one year. Factors linked with the response of six months include old age at the time of diagnosis, hypertension, activity, time frame of indications before therapy and chronicity indices. Hypertension and chronic index are indicators of logistic regression response at the time of six months. Our research paper the cases of proliferative lupus represent lower rate if proteinuria, eGFR and elevated scores of chronicity when compared to African-American and Caucasian cases. Associated factors with response at six months include old age at the time of diagnosis, hypertension, activity, time frame of indications before therapy and chronicity indices. In Caucasian case similar short-term results were observed.
Keywords: Systemic Lupus Erythematosus, Chronic, Immune Disorder, Kidney Inflation
Comparison Of The Outcome Of Distal Radius Intra-Articular Fracture Treated With Volar Locking Plate Versus Wrist Spinning External Fixator
No full textObjective: To compare the functional outcome of patients with comminuted intra-articular distal radius fractures managed with volar locking plate and wrist spanning external fixator using the QuickDASH Score.
Methods: This prospective comparative study was conducted at –removed for blind review-- from December 2024 to May 2025, and a total of 46 patients were included in the study, with 23 patients in each group. Non-probability consecutive sampling was used. The QuickDASH score was calculated after the 16th post-operative week. The functional outcome score between the two groups was analysed using an independent sample t-test using SPSS 27.
Results: The mean age of patients in the VLP group was 48.00 ± 10.78 years, while in the Exfix group it was 45.43 ± 12.09 years. A higher proportion of patients were male, accounting for 73.9% of the study population, whereas females comprised 26.1%. The mean QuickDASH score in the VLP group (8.38 ± 3.43) was significantly lower than the mean score in the Exfix group (11.16 ± 3.99), indicating better functional outcomes in the VLP group. This difference was statistically significant with t(44) = -2.532 and p = 0.015.
Conclusion: Management of distal radius, comminuted intra-articular fractures with volar locking plate offers superior short-term functional outcomes, as demonstrated by lower QuickDASH scores at 16 weeks postoperatively.
Keywords: radius fracture, Intra-articular fractures, External fixator, Comminuted fracture, Anatomical reduction, Premature degenerative osteoarthriti
