11 research outputs found
First person – Prajakta Gosavi
No full textABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Prajakta Gosavi is the first author on ‘The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity’, published in Journal of Cell Science. Prajakta is a postdoctoral research fellow in the lab of Paul Gleeson at the University of Melbourne, Parkville, Australia, investigating the role of the Golgi ribbon structure in the regulation of cellular signalling pathways and higher-order functions under physiological as well as disease conditions.</jats:p
Relationship between Prosocial behaviour and Aggression among College Students
No full textAbstract: Several changes occur throughout the transition to maturity, including changes in behaviour, emotions, and cognitions. Growing maturity occurs hand in hand with other demands during the transition from adolescent to adulthood, such as taking care of oneself and others, making independent decisions, and becoming self-sufficient. Prosocial behaviour can be one of the factors to reduce aggressive actions. Both being the components of social psychology, this study aims at finding a correlation between the two in college going students. A total 102 students (Nmales=28, Nfemales=72) participated for the study from India. Prosocialness scale by Caprara et. al. 2005(Mfemales =64.63, SD=9.03), (Mmales =59.66, SD=9.36), (t=2.422ns) and Aggression Questionnaire by Buss., A.H., & Perry, M. 1992 (Mfemales =72.30, SD=15.27), (Mmales=73.62, SD=17.902), (t=-.360ns) were used for measurements. The study indicated that there is no significant difference amongst males and females in relation with prosocial behaviour and aggression. Results indicated negative correlation between prosocial behaviour and aggression but non-significant (r=-0.17 ns).
Keywords: Prosocial behaviour, Aggression, Social Psychology.
Title: Relationship between Prosocial behaviour and Aggression among College Students
Author: Dr. Prajakta Bhadgaonkar
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
Vol. 11, Issue 1, January 2023 - March 2023
Page No: 5-10
Research Publish Journals
Website: www.researchpublish.com
Published Date: 10-January-2023
DOI: https://doi.org/10.5281/zenodo.7520289
Paper Download Link (Source)
https://www.researchpublish.com/papers/relationship-between-prosocial-behaviour-and-aggression-among-college-studentsInternational Journal of Interdisciplinary Research and Innovations, ISSN 2348-1218 (print), ISSN 2348-1226 (online), Research Publish Journals, Website: www.researchpublish.co
Experimental Study of Slip Flow in the Semi-hyperbolically Converging Dies
No full textThis dissertation contains a collection of the results from three different projects.
Part I: Experimental Study of Slip Flow in the Semi-hyperbolically Converging Dies
Elongational flow fields are of immense importance in the polymer processing industry as the elongational flow used in processes such as fiber spinning, film blowing, melt drawing, etc., produces the desired degree of polymer orientation so that the final products have the target properties of toughness and durability. Although these processes are widely used, it is very difficult to characterize the extensional rheological properties of polymers, such as elongational viscosity. This can be attributed to the difficulty in developing the experimental methods for measuring the elongational flow properties.
In late 1990s, Collier and co-workers began work on a project aimed at developing an inexpensive, reliable, accurate, and simple to use device to measure the elongational viscosity of polymer melts in a uniaxial elongational field. They have developed the semi-hyperbolically converging dies, the shape of which follows the natural pathways of the streamlines required to produce a purely uniaxial elongational field, provided that the assumptions used in the theoretical development are satisfied. We have continued the work with the semi-hyperbolically converging dies developed by Collier and co-workers. The research focused on analyzing the assumptions used in the development of these dies.
The semi-hyperbolically convergent dies are used to measure the effective elongational viscosities of polymer melts and solutions at the industrial processing conditions. Based on a recent study by Feigl et al., it was confirmed that when full slip was assumed at the die walls in the semi-hyperbolically convergent dies, one can obtain an essentially purely uniaxial elongational flow. The degree of slippage taking place in these dies was scrutinized experimentally in our research based on the knowledge that small amounts of carboxylic acid additives can greatly reduce the shear viscosity in many polymer melts. We used the Mooney analysis to quantify the slip in capillary dies for various thermoplastics such as polypropylene, low-density polyethylene, and high density polyethylene. The Mooney equation was modified to fit the semi-hyperbolically convergent dies. Experiments were then performed to quantify the degree of slip in both the capillary and the semi-hyperbolically convergent dies.
Part II: Shear Thickening in Dilute Polymer Solutions: Transient Analysis
Transient shear properties of dilute polymer solutions were investigated in the shear-rate regions where shear thickening can occur. Comparison of transient rheological and optical data with the Two Coupled Maxwell Modes Model offered insight into the physical mechanisms that give rise to this anomalous behavior. Specifically, shear thickening occurs due to the deterioration of the size and anisotropy of structures deformed at lower shear rates. Coincident theoretical and experimental discontinuities in the transient profiles of the dichroic orientation angle appear to confirm the prior statement.
Part III: Additional Experimental Research in Polymer Melt Rheology
Shear flow of low-density polyethylene was investigated in other non-dissertation related work. Small amplitude oscillatory shear experiments and steady shear experiments were performed on an industrial grade LDPE and the experimental data was used in modeling work of rheological properties of polymeric fluids. I am the co-author on two published articles on this work, and a third currently under preparation. My contributions included performing several types of experiments, such as transient and steady shear experiments, small amplitude oscillatory shear flow, elongational flow, and step-strain experiments. This additional research is not considered as part of this dissertation, so only a brief summary is described in this document
Regional liquefaction-induced ground displacement predictions for Canada Using 5th Generation NBCC seismic hazard model
No full textSignificant regions of Canada are seismically active, and areas underlain by loose, saturated sediments in these regions are expected to experience liquefaction-induced lateral spread permanent ground displacements (PGDs) under earthquake shaking. The empirical predictive equations are commonly used for estimating the PGDs especially when detailed numerical analyses are not undertaken. The key input parameters for these equations comprise earthquake magnitude (M) and source distance (R), along with geotechnical and topographic parameters; however, there is ambiguity over choosing appropriate site-specific values of M and R. The current study predicts PGD probabilistic hazard curves that are applicable for locations in South-western and South-eastern regions of Canada using a probabilistic seismic hazard assessment (PSHA) framework. This was achieved by embedding two relevant empirical models for predicting lateral spread PGDs (replacing the ground motion prediction equations) within the 2015 National Building Code of Canada framework that is currently available in OpenQuake platform. Moreover, deaggregation analyses have been performed to understand the M and R contributions from different seismic sources on the predicted site-specific hazard. The developed PGD curves can be readily adopted for estimating site-specific lateral spread PGD demand as input to performance-based design of structures in seismically active areas of Canada.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Systematic development and mesh sensitivity analysis of a mathematical model for an anode baking furnace
No full textThe anode baking process is developed and improved since the 1980s due to its importance in Aluminium industry. The process is characterized by multiple physical phenomena including turbulent flow, combustion process, conjugate heat transfer, and radiation. In order to obtain an efficient process with regards to quality of anodes, soot-free combustion, reduction of NOx and minimization of energy, a mathematical model can be developed. A mathematical model describes the physical phenomena and provides a deeper understanding of the process. Turbulent flow is one of the important physical phenomena in an anode baking process. In the present work, isothermal turbulent flow is studied in detail with respect to two turbulence models in COMSOL Multiphysics software. The difference between wall boundary conditions for these models and their sensitivity towards the boundary layer mesh is investigated. A dimensionless distance in viscous scale units is used as a parameter for comparison of models with and without a boundary layer mesh. The investigation suggests that the boundary layer mesh for both turbulence models increase the accuracy of flow field near walls. Moreover, it is observed that along with the accuracy, the numerical convergence of Spalart-Allmaras turbulence model in COMSOL Multiphysics is highly sensitive to the boundary layer mesh. Therefore, development of converged Spalart-Allmaras model for the complete geometry is difficult due to the necessity of refined mesh. Whereas, the numerical convergence of k-ε model in COMSOL Multiphysics is less sensitive to the dimensionless viscous scale unit distance. A converged solution of the complete geometry k-ε model is feasible to obtain even with less refined mesh at the boundary. However, a comparison of a developed solution of k-ε model with another simulation environment indicates differences which enhance the requirement of having converged Spalart-Allmaras model for complete geometry.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Numerical AnalysisMathematical Physic
Developing A Secure Cloud Storage System for Storing IoT Data by Applying Role Based Encryption
No full textAbstractInternet of things is one of the most emerging and popular technology, which has changed our life, by impacting different areas such as shopping, enterprise production, storage, monitoring physical devices, etc. The Internet of Things (IoT) is an atmosphere in which all physical objects, peoples or animals are having unique identity and they are able to transfer data over a network without any interaction. An improvement in electronic sensing devices and rapid growth in communication infrastructure, and their monitoring systems give very fast access to retrieve data and allow communication with physical devices. Now days, Organizations use IoT devices to collect real time and continuous data and make better business decisions to increase customer satisfaction. But collected data need to be processed and transferred in appropriate format to store on storage system – which is triggering organizations to rethink their data storage infrastructures. An enterprise has to store data generated from the Internet of Things and this data grows exponentially, it forces to think about cloud storage for storing IoT data. The proposed work allows the organization to store the IoT data on the cloud securely by applying different Access control policies and the cryptography concepts
Analysis of the aerodynamics in the heating section of an anode baking furnace using non-linear finite element simulations
No full textThe emissions from the industrial furnaces impact the environment. Among the various factories, those having anode baking furnaces are working on reducing the pollutant emissions. The aerodynamics in the furnace influences the emissions due to the high dependence of combustion and radiation phenomena on the mixing characteristics. Therefore, this paper aims to establish the numerical simulation results for the three-dimensional turbulent flow in a single section of an anode baking furnace with a high rate of fuel injection. The stabilized non-linear finite element approach on the Reynolds-averaged Navier-Stokes (RANS) equation is used with COMSOLMultiphysics. The turbulent viscosity ratio is highly sensitive to the mesh for the standard k-ε model. The requirements of the Cartesian and refined mesh near the jet development region is explained. The comparison of meshes generated by two meshing tools namely cfMesh and COMSOL Multiphysics default Mesher is carried out. The high numerical diffusion in the flow models due to the coarser mesh leads to convergence but deficit the precision in the results. This paper shows that the mesh generated by cfMesh with flow aligned refinement combined with the non-linear finite element solver in COMSOL Multiphysics proves to provide accurate results of turbulent quantities.Ook verschenen als rapport: Reports of the Delft Institute of Applied Mathematics ISSN (Print): 1389-6520 Volume: 20-07Numerical AnalysisMathematical Physic
A cross-sectional study exploring patient experiences, unmet needs and desired support in those with olfactory dysfunction
No full textObjectives: Smell and taste disorders (SATDs) are frequently overlooked despite growing prevalence. They profoundly impact quality of life. Effective therapies for SATDs remain scarce. This survey aimed to assess patient views surrounding the support available at the time of onset of SATDs, and what further support is needed. Design and Setting: This was a cross-sectional study consisting of an online survey circulated via the UK charity SmellTaste (known as Fifth Sense until a rebrand in May 2025), exploring features and impacts of SATDs, and opinions surrounding support available, and any further support felt to be necessary by those formally diagnosed or self-identifying with SATDs. Main Outcomes: Survey questions were grouped largely into the domains of demographics, features of olfactory issues, impact of disorder, and support network. Results: A total of 410 participants completed the questionnaire, with the majority being women. When asked how olfactory dysfunction made participants feel, common responses included: ‘sad’, ‘devastated’, ‘angry’, ‘anxious’, ‘depressed’, ‘isolated’ and ‘grief’. Family was reported as the greatest source of support when diagnosed with SATDs (partner/spouse, 36.4%; other family member, 15.1%) followed closely by SmellTaste (34%). Only 2.5% reported General Practitioners as their greatest source of support, with many participants reporting that primary care providers could not provide adequate help, leaving them to seek advice elsewhere (support groups, family, friends and self-investigation). Further support, covering medical, psychological and social interventions, was considered important. Conclusion: Given the complexity of issues experienced and the lack of formal support available for people with SATDs, there is a clear need for an intervention addressing unmet support needs
The nitric oxide formation in anode baking furnace through numerical modeling
No full textThermal nitric-oxide (NOx) formation in industrial furnaces due to local overheating is a widely known problem. Various industries made significant investments to reduce thermal NOx by varying the operating conditions and designs of the furnace. It is difficult to find the optimal operating conditions that minimize NOx formation in the furnace by trial and error methods. The high temperature in the furnace complicates performing experiments in the furnace. Numerical modeling can provide significant information in such cases. Therefore, the objective of this paper is to obtain a numerical model of the furnace in such a way that the operating conditions can be varied and examined. In this paper, a three-dimensional steady-state finite element model for the anode baking industrial furnace is discussed. The COMSOL Multiphysics software is used for modeling the non-premixed turbulent combustion and the conjugate heat transfer to the insulation lining. The cfMesh software is used for obtaining the mesh. The results show that the simulated temperature agrees well with the measured data from our industrial partner in regions distant from the flames. The analysis shows that by decreasing the fuel mass flow rate and increasing the fuel pipe diameter by 45%, the peak in thermal NOx ppm generated in the furnace decreases by 42%. The model is limited by the use of a single-step chemistry mechanism with an eddy dissipation combustion model and a simplified approach for radiation, such as the P1 approximation model. The model can be further improved by considering a detailed chemistry mechanism model for combustion and a discrete ordinate model for radiation.Numerical AnalysisMathematical Physic
Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization
No full textUpon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mechanism of kinase activation, however, has not been elucidated. Here, using hydrogen deuterium exchange mass spectrometry (HDX-MS), small angle X-ray scattering (SAXS) and molecular dynamics (MD) simulations, combined with analysis of SMAD signaling, we show that the kinase domain of the type I receptor ALK2 and type II receptor BMPR2 form a heterodimeric complex via their C-terminal lobes. Formation of this dimer is essential for ligand-induced receptor signaling and is targeted by mutations in BMPR2 in patients with pulmonary arterial hypertension (PAH). We further show that the type I/type II kinase domain heterodimer serves as the scaffold for assembly of the active tetrameric receptor complexes to enable phosphorylation of the GS domain and activation of SMADs.This article is published as Agnew, C., Ayaz, P., Kashima, R. et al. Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization. Nat Commun 12, 4950 (2021). https://doi.org/10.1038/s41467-021-25248-5. © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/
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