6,125 research outputs found
Comparison of germline mosaics of genes in the polycomb group of Drosophila-melanogaster.
No full textCommunity structure of ground-dwelling vertebrates sampled with drift-fence pitfall traps in a subtropical montane forest in central Taiwan.
No full textComparison of Protein Phosphatase Inhibitory Activities and Acute Toxicity of Microcystins
No full textEight naturally purified microcystins (MCs), including MC-LR, MC-FR,
MC-WR, MC-RR, [D-Asp3] MC-FR, [D-Asp3] MC-WR, [D-Asp3] MC-RR and [Dha7]
MC-RR were utilized to determine the effects of amino acid substitutions and
modifications on the MC-induced phosphatase inhibitory activity and animal toxicity.
It was found that the replacement of the non-polar amino acid L-leucine at the second
position of these heptacyclic peptide toxins by a polar L-arginine greatly reduced their
animal toxicities and inhibitory activities against protein phosphatase 1 (PP-1) and 2A
(PP-2A). Demethylation of methyldehydroalanine at the seventh amino acid position
of MC-RR showed the least animal toxicity and phosphatases inhibition. The loss of
methyl group on the common methylaspartic acid (MeAsp) at the third position of
MCYST-FR, MCYST-WR and MCYST-RR did not alter their toxicity levels, but
significantly reduced their activities in PP-1 inhibition. It suggests that the methyl
group on MeAsp is essential in PP-1 inhibition for MCs. However, such a tendency
was not observed in the assay of PP-2A activity. Comparing the LD50 of the mouse
toxicity assay and IC50 of the PP-1 and PP-2A inhibition assay of eight forms of
microcystins by linear correlation, it was clearly demonstrated that the MC-induced
toxicity is much more related to the inhibition of PP-2A than PP-1. These results
suggest that PP-2A inhibition plays a major role in the MC-induced toxicity
C-elegans CED-12 acts in the conserved CrkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.
No full textFeeding habits of the pantropical spotted dolphin, Stenella attenuata, off the Eastern coast of Taiwan.
No full textInteractively using Semantic Web knowledge: Creating scalable abstractions with FacetOntology
No full textThe amount of knowledge accessible on the Semantic Web is growing, and there is a need for a scalable solution to facilitate exploring that data. Currently approaches to exploring Semantic Web data either focus on exploring resources individually, following links during exploration, and making little use of collated data, or take the approach of collating and aligning multiple sources into one store for one purpose, and hand-crafting a specific browsing interface onto it. We present an approach that provides a scalable browsing interface, which can browse knowledge from the Semantic Web at will. Our approach creates abstractions of knowledge, collated into facets, which are described using FacetOntology. FacetOntology facilitates describing facets from RDF data, suitable for use in creating datasets for faceted browsing
Growth Morphologies and Mechanisms of Non-Equilibrium Solidified MC Carbide
No full textGrowth morphologies and mechanisms of the carbide of group IVB and VB elements (MC carbide), a typical faceted crystal, were studied with an estimated cooling rate from 102 to 105 K/s. Results showed that although the growth morphologies of the MC carbide vary remarkably with solidification cooling rate, the solid/liquid interface is always atomically smooth, and the growth mechanisms are always lateral growth. The growth mechanism transition from lateral to continuous growth mode, which was predicted by the classic crystal growth theory, was not observed for the TiC type MC carbide within the estimated cooling rate range of 102?105 K/s
Seasonal variation of chickenpox, mumps and rubella in Taiwanese children estimated by pediatric clinics
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