4 research outputs found

    Effects of storage solutions on in vitro vasoreactivity of radial artery conduits

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    AbstractObjectives: Surgical preparation of coronary conduits for coronary artery bypass grafting may affect their early and long-term patency; one mechanism may involve endothelial damage. We investigated the effect of 3 commonly used solutions—Ringer's solution, normal saline solution, and heparinized whole blood—on in vitro endothelial and contractile functions of the human radial artery. Methods: Radial artery segments were harvested, cut into 3-mm rings, and stored in unoxygenated Ringer's solution, normal saline solution, or heparinized whole blood for 45 minutes. Rings stored in Krebs solution were used as controls. The rings were then mounted and stretched to an optimal resting tension in oxygenated Krebs solution at 37°C. Contraction responses to potassium, norepinephrine, and serotonin and relaxation responses to acetylcholine, verapamil, and nitroprusside were evaluated. Results: Fifty-six radial artery ring segments from 14 patients (n = 7 rings for each contaction-relaxation curve) were studied. Equilibrated resting tension was 9.6 ± 0.3 mN (5.9 ± 0.2 g), and resting internal circumference was 6.4 ± 0.2 mm. Absolute maximum contraction to potassium was significantly less in rings stored in normal saline solution than in rings stored in control solution (10.7 ± 0.6 g vs 14.5 ± 0.6 g, P < .01; 95% confidence intervals, 0.9-6.9). There was no difference in the contraction to norepinephrine (P = .11) and serotonin (P = .25) among the 3 solutions compared with the control solution. Rings stored in heparinized whole blood had significantly greater endothelium-dependent relaxation to acetylcholine (P < .007), whereas those stored in normal saline solution had reduced responses. Endothelium-independent relaxation to verapamil and nitroprusside were similar among the 3 solutions. Conclusion: Heparinized whole blood is a better physiologic medium for preservation of radial artery endothelial and contractile functions during storage before grafting

    Predatoros, or, The brigand's bride : comic opera, in two acts / written by Francis Hart ; composed by Sir W.C.F. Robinson.

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    Electronic reproduction. Canberra, A.C.T. : National Library of Australia, 2012.; The MS leather bound copy is inscribed by the author: "To George Musgrove from his friend Francis Hart".Predatoros. LibrettoBrigand's bride

    Candidate Distant Trans-Neptunian Objects Detected by the New Horizons Subaru TNO Survey

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    Fraser, Wesley C. et al.-- Full list of authors: Fraser, Wesley C.; Porter, Simon B.; Peltier, Lowell; Kavelaars, JJ; Verbiscer, Anne J.; Buie, Marc W.; Stern, S. Alan; Spencer, John R.; Benecchi, Susan D.; Terai, Tsuyoshi; Ito, Takashi; Yoshida, Fumi; Gerdes, David W.; Napier, Kevin J.; Lin, Hsing Wen; Gwyn, Stephen D. J.; Smotherman, Hayden; Fabbro, Sebastien; Singer, Kelsi N.; Alexander, Amanda M.; Arimatsu, Ko; Banks, Maria E.; Bray, Veronica J.; Ramy El-Maarry, Mohamed; Ferrell, Chelsea L.; Fuse, Tetsuharu; Glass, Florian; Holt, Timothy R.; Hong, Peng; Ishimaru, Ryo; Johnson, Perianne E.; Lauer, Tod R.; Leiva, Rodrigo; S. Lykawka, Patryk; Marschall, Raphael; Núñez, Jorge I.; Postman, Marc; Quirico, Eric; Rhoden, Alyssa R.; Simpson, Anna M.; Schenk, Paul; Skrutskie, Michael F.; Steffl, Andrew J.; Throop, HenryWe report the detection of 239 trans-Neptunian objects discovered through the ongoing New Horizons survey for distant minor bodies being performed with the Hyper Suprime-Cam mosaic imager on the Subaru Telescope. These objects were discovered in images acquired with either the r2 or the recently commissioned EB-gri filter using shift and stack routines. Due to the extremely high stellar density of the search region downstream of the spacecraft, new machine learning techniques had to be developed to manage the extremely high false-positive rate of bogus candidates produced from the shift and stack routines. We report discoveries as faint as r2 ∼ 26.5. We highlight an overabundance of objects found at heliocentric distances R ≳ 70 au compared to expectations from modeling of the known outer solar system. If confirmed, these objects betray the presence of a heretofore-unrecognized abundance of distant objects that can help explain a number of other observations that otherwise remain at odds with the known Kuiper Belt, including detections of serendipitous stellar occultations, and recent results from the Student Dust Counter on board the New Horizons spacecraft. © 2024. The Author(s).The authors wish to recognize and acknowledge the very significant cultural role and reverence that the summit of Maunakea has always had within the indigenous Hawaiian community. We are most fortunate to have the opportunity to conduct observations from this mountain. This research is based on data collected at the 8.2 m Subaru Telescope (https://subarutelescope.org/en/) using its prime focus camera (the Hyper Suprime-Cam), operated by the National Astronomical Observatory of Japan. The Subaru Telescope provided the main source of data for this work. We would like to thank the director, Subaru staff, and the TAC for working with us to accommodate our complex scheduling requirements. This research is based on observations from programs GS2019B-FT-102, GN-2020A-DD-103, and GS-2020A-DD-103 obtained at the international Gemini Observatory, a program of NSFʼs NOIRLab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation on behalf of the Gemini Observatory partnership: the National Science Foundation (United States), National Research Council (Canada), Agencia Nacional de Investigación y Desarrollo (Chile), Ministerio de Ciencia, Tecnología e Innovación (Argentina), Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brazil), and Korea Astronomy and Space Science Institute (Republic of Korea). This work was supported by a NASA Keck PI Data Award, administered by the NASA Exoplanet Science Institute. Data presented herein were obtained at the Subaru Telescope from telescope time allocated to the National Aeronautics and Space Administration through the agency's scientific partnership with the California Institute of Technology and the University of California. This research used the Canadian Astronomy Data Centre facilities operated by the National Research Council of Canada with the support of the Canadian Space Agency. This work also made use of the Gemini Observatory Archive, NASAʼs Astrophysics Data System Bibliographic Services, and the JPL Horizons web interface (https://ssd.jpl.nasa.gov/horizons.cgi). New Horizons scientists Stern, Benecchi, Buie, Fraser, Lauer, Kavelaars, Peltier, Porter, and Verbiscer thank NASA’s New Horizons Mission (NASW-02008) for funding. This work made use of the Pan-STARRS1 Surveys (PS1) and the PS1 public science archive, which have been made possible through contributions by the Institute for Astronomy, the University of Hawaii, the Pan-STARRS Project Office, the Max-Planck Society and its participating institutes, the Max Planck Institute for Astronomy, Heidelberg and the Max Planck Institute for Extraterrestrial Physics, Garching, Johns Hopkins University, Durham University, the University of Edinburgh, the Queen’s University Belfast, the HarvardSmithsonian Center for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated, the National Central University of Taiwan, the Space Telescope Science Institute, the National Aeronautics and Space Administration under grant No. NNX08AR22G issued through the Planetary Science Division of the NASA Science Mission Directorate, the National Science Foundation grant No. AST1238877, the University of Maryland, Eotvos Lorand University (ELTE), the Los Alamos National Laboratory, and the Gordon and Betty Moore Foundation. This paper makes use of LSST Science Pipelines software developed by the Vera C. Rubin Observatory. We thank the Rubin Observatory for making their code available as free software at https://pipelines.lsst.io. We also thank the former and current directors of the Subaru Telescope, Michitoshi Yoshida and Satoshi Miyazaki, for opening the Subaru Telescope to collaborate with the New Horizons mission. Finally, W.C.F. would like to thank B.C.P. and D.R. for their insightful comments. Software: parallel (O. Tange 2011), numpy (C. R. Harris et al. 2020), matplotlib (J. D. Hunter 2007), TRailed Imaging in Python, (W. Fraser et al. 2016), astropy (Astropy Collaboration et al. 2013, 2018), SExtractor (E. Bertin & S. Arnouts 1996).Peer reviewe
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