3,209 research outputs found
Immuno-oncology for B-cell lymphomas
No full textThe goal of cancer immunotherapy is to restore and optimize the immune response against malignant clones through several stages, from recognition of tumor antigens to establishment of long-lived memory cell populations. Boosting the intrinsic anti-tumor immune responses of the patients' own, several types of “active immunotherapies” have been tried in many types of malignancies, inspired by successful experiences of immune checkpoint inhibition even in Hodgkin lymphoma. However, in B-cell non-Hodgkin lymphomas, clinical usefulness of such “active immunotherapies” is relatively unsatisfactory considering the remarkable advances in “passive immunotherapy,” including CD19-targeting chimeric antigen receptor T-cell therapy. Understanding how tumor cells and immune cells interact and contribute to immune evasion processes in the tumor microenvironment (TME) is an important prerequisite for the successful restoration of anti-tumor immune responses. In this review, a recent understanding of the biology of the immune tumor microenvironment surrounding B-cell non-Hodgkin lymphomas will be introduced. In addition, novel therapeutic approaches targeting the immune microenvironment other than immune checkpoint blockade are discussed
Norm attaining bilinear forms on L-1[0,1]
No full textWe show that the set of norm attaining bilinear forms on L-1[0, 1] is not dense in the space of all continuous bilinear forms. (C) 1997 Academic Press.X1124sciescopu
Recent advances in the management of primary central nervous system lymphoma
No full textPrimary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal lymphoma primarily involving the brain, spinal cord, or leptomeninges. PCNSL is associated with a relatively poor prognosis compared to other extranodal diffuse large B-cell lymphomas. However, methotrexate-based induction chemotherapy followed by consolidative chemotherapy or high-dose therapy and autologous stem cell transplantation has improved the survival outcome, together with reduced neurotoxicity. Recent studies found that aberrant activation of the B-cell receptor-signaling pathway and activation of the NF-kappaB are frequent genetic alterations and could be good targets for the treatment of PCNSL. Herein, we have reviewed the current status and recent advances in the biology and management of PCNSL
Norming points and critical points
No full textUsing a diffeomorphism between the unit sphere and a closed hyperplane of an infinite dimensional Banach space, we introduce the differentiation of a function defined on the unit sphere, and show that a continuous linear functional attains its norm if and only if it has a critical point on the unit sphere. Furthermore, we provide a strong version of the Bishop-Phelps-BollobAs theorem for a Lipschitz smooth Banach space.110sciescopu
The Bishop-Phelps-Bollobas theorem on bounded closed convex sets
No full textThis paper deals with the Bishop-Phelps-Bollobas property (BPBP) on bounded closed convex subsets of a Banach space X, not just on its closed unit ball B-X. We prove that BPBP holds for bounded linear functionals on arbitrary bounded closed convex subsets of a real Banach space. We show that, for a Banach space Y with property (beta), the pair (X, Y) has BPBP on every bounded closed absolutely convex subset D of an arbitrary Banach space X. For a bounded closed absorbing convex subset D of X with a positive modulus of convexity, we show that the pair (X, Y) has BPBP on D for every Banach space Y. We further obtain that, for an Asplund space X and for a locally compact Hausdorff space L, the pair (X, C-0(L)) has BPBP on every bounded closed absolutely convex subset D of X. Finally, we study the stability of BPBP on a bounded closed convex set for the l(1)-sum or l(infinity)-sum of a family of Banach spaces.1120sciescopu
Property (quasi-alpha) and the denseness of norm attaining mappings
No full textWe introduce property (quasi-alpha), which implies property (A) defined by Lindenstrauss [10] and whose dual property is property (quasi-beta) [2]. We consider relations between this property and other sufficient conditions for property (A), and study the denseness of norm attaining mappings under the conditions of these properties. In particular, if each of the Banach spaces X-k, 1 <= k <= n - 1, has property (quasi-alpha) and X-n has property (A), then the projective tensor product X-1(circle times) over cap (pi) ... (circle times) over cap X-pi(n) has property (A). (C) 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.X111sciescopu
The lambda-function in the space P((2)l(2)(2))
No full textIn this note, motivated by the question 1 in (Aron and Lohman, Pacific J. Math. 127 (1987), 209-231), we obtain an explicit formula for the lambda-function in the real space P((2)l(2)(2)). From this we see that the X-function is continuous and attained at each point of the unit ball of P((2)l(2)(2)), the space of real-valued continuous 2-homogeneous polynomials on l(2)(2).open11sci
The Bishop-Phelps-Bolloba's theorem fails for bilinear forms on l(1) x l(1)
No full textIn this paper we show that the Bishop-Phelps-Bollobas theorem fails for bilinear forms on l(1) x l(1), while it holds for linear operators from l(1) to l(infinity). (C) 2009 Elsevier Inc. All rights reserved.X111415sciescopu
The Bishop-Phelps-Bollobas theorem for operators from L(1)(mu) to Banach spaces with the Radon-Nikodym property
No full textLet Y be a Banach space and (Omega, Sigma, mu) be a a-finite measure space, where Sigma is an infinite alpha sigma-algebra of measurable subsets of Omega. We show that if the couple (L-1 (mu), Y) has the Bishop-Phelps-Bollobas property for operators, then Y has the AHSP. Further, for a Banach space Y with the Radon-Nikodym property, we prove that the couple (L-1(mu), Y) has the Bishop-Phelps-Bollobas property for operators if and only if Y has the AHSP. (C) 2011 Elsevier Inc. All rights reserved.X111717sciescopu
Extreme polynomials on C-0
No full textWe prove that every monomial in P((m)c(0)) is a strong extreme point of the unit ball of P((m)c(0)) in the complex case, and show that in P((2)c(0)) there is an extremal but not extreme polynomial in the real case. Moreover, we show that there is no extremal polynomial in P((m)c(0)) in the complex case.X1114sciescopu
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