469 research outputs found
Correction:Idelalisib exposure before allogeneic stem cell transplantation in patients with follicular lymphoma: an EBMT survey
Full text linkThe article “Idelalisib exposure before allogeneic stem cell transplantation in patients with follicular lymphoma: an EBMT survey”, written by Leopold Sellner, Johannes Schetelig, Linda Koster, Goda Choi, Didier Blaise, Dietrich Beelen, Fabrizio Carnevale Schianca, Jakob Passweg, Urs Schanz, Emmanuel Gyan, Federica Sora, Nicolaus Kröger, Gerald. G. Wulf, Gwendolyn Van Gorkom, Jiri Mayer, Corentin Orvain, Jean Henri Bourhis, Pavel Jindra, Victoria Potter, Francesco Zallio, Elisabeth Vandenberghe, Stephen Robinson, Patrick J. Hayden, Ibrahim Yakoub-Agha, Silvia Montoto, Peter Dreger, on behalf of the European Society for Blood and Marrow Transplantation Lymphoma and Chronic Malignancies Working Parties, was originally published Online First without Open Access. After publication in volume 55, issue 12, page 2335–2338, the author decided to opt for Open Choice and to make the article an Open Access publication.</p
Design Caisson breakwater: An evaluation of the formula of Goda
No full textThe growing need for breakwaters in deep water due to the increasing draught of large vessels draws the attention to caisson breakwaters. These monolithic structures are more economical compared to rubble mound breakwaters. Especially in deep water lower construction and maintenance costs and considerable savings in construction time can be realised. A caisson is built on shore and towed out to the actual offshore site. Unfortunately, damage at a caisson is often progressive. This causes an abrupt collapse of the structure. By understanding the dynamic processes involved, the design of the structure can be soundly based. The formula of Goda (1985) is a worldwide used design method for vertical breakwaters based on the quasi-static approach. His design method is very useful as a first indication for the dimensions of the caisson. In order to be able to analyse Goda's method, the design of a caisson breakwater is roughly divided in three phases. First the crest elevation of the caisson, the design wave and the design water depth, are determined with probabilistic considerations about the economy of the harbour. Subsequently the wave load follows from the wave pressure formulae. Thirdly, the width of the structure sets the weight of the structure which defines the safety against failure. Goda sets the design parameters on definite values regardless the cost-benefit analysis of the harbour. His design wave is the highest wave in the design sea state, which is based on the principle that a breakwater should be designed to be safe against the single wave with the largest pressure among storm waves. From the comparison of the measured wave forces of the hydraulic model study and the values calculated with the wave pressure formulae of Goda and of the linear wave theory no conclusions can be drawn. This is partly due to the close resemblance of the results of the linear wave theory and Goda's formula for the conditions at Europoort Rotterdam and partly caused by the scatter in the measurements. An experiment about the failure mechanisms of the caisson confirms the introducing of uncertainties concerning the placing of the caisson on the rubble mound foundation. Goda's wave pressure formulae turned out to be in fact design formulae. Not only his design parameters but the formulae themselves include safety considerations. Evaluation of Goda's formula is therefore only valid when the whole design process is taken into account. It is noted that the accuracy of the calculated wave pressure on the wall is very good with respect to the uncertainties introduced in the foundation forces and the determination of the design parameters.Hydraulic EngineeringCivil Engineering and Geoscience
Transfer of a person under the european arrest warrant.
No full textThe author studies a legal measure, which was introduced by a type of European Union law known as Framework Decision, adopted in June 2002 by the European Union Council of Ministers. Lithuania has implemented the Framework Decision on the European Arrest Warrant by making modifications to the national Criminal Code and the Code of Criminal Procedure. It should be noted, that the European Arrest Warrant is the first European instrument, implementing the principle of mutual recognition. The master‘s thesis deals with the concept and system of the European Arrest Warrant, it’s historical development, examines mandatory and discretionary grounds for non execution of the European Arrest Warrant, legal procedure, requirements of the form and content of the European Arrest Warrant. The author also focuses on some obstacles and problems found at national level during implementation of the Framework Decision. Furthermore, the author analyzes the statistical rates of issuing European Arrest Warrant and the surrendered persons to Lithuania. Aditionally, the master’s thesis is illustrated by practical application of the European Arrest Warrant. Finally, the author gives summarized conclusions and makes particular suggestions for improving existing legal norms, which regulate the European Arrest Warrant
Towards high-speed computational scattered light imaging by introducing compressed sensing for optimized illumination
No full textWe propose the application of Compressed Sensing to Computational Scattered Light Imaging to decrease measurement time and data storage. Computational Scattered Light Imaging (ComSLI) determines three-dimensional fiber orientations and crossings in biomedical tissues like brain tissue. Currently, conventional ComSLI is time-consuming and generates large data. Compressed Sensing reconstructs signals with fewer samples than required by the Shannon-Nyquist theorem with minimal perceptual loss, significantly reducing the number of measurements. We introduce an optimized illumination strategy for ComSLI based on the Discrete Cosine Transform and validate it by reconstructing characteristic scattering patterns in vervet brain tissue, thereby demonstrating the feasibility of Compressed Sensing in ComSLI.ImPhys/Menzel grou
Goda Karte
No full textStamoed certificate which reads; Edmonton Latvian Society Imanta. F.J. Baker1.0 Imanta, 1.1.1 Historyof Imanta in Albert
Evaluation and validation of the spectral linear wave theory and ‘traditional’ formulae for pulsating wave loads for unimodal and bimodal seas: Comparison to Goda and measurements
No full textFor the design of vertical hydraulic structures pulsating wave forces need to be calculated. The total wave force is a result of every wave component (long waves and short waves) within a wave field. The common formulae are derived for regular or unimodal narrow sea states and use one characteristic wave height and period. Broad-banded spectra like bimodal sea states are present at many locations. Moreover, new hydraulic structures like Panamax or post-Panamax locks do have a large vertical surface exposed to pulsating wave loads. Swell components within the wave spectrum are disproportionally contributing to the total wave force compared to short waves. This depth effect for broad-banded or bimodal wave spectra is not considered by the traditional wave formulae which could result in significant underestimations of wave forces on hydraulic structures.This paper aims to determine the wave loads of irregular non-breaking wave fields under any wave spectrum: narrow banded, broad-banded, or bimodal. Spectral linear wave theory (LWT) is used to transform any wave spectrum to a wave force spectrum. The wave force or wave pressure at any level can directly be evaluated from the wave force spectrum or wave pressure spectrum for any shape of the wave spectrum considered within this research. Spectral LWT is compared to the outcome of wave flume experiments with bimodal seas and other wave force formulae, like the Goda formula and quasi-regular LWT and the NewWave theory.This paper gives a description and evaluation of the spectral LWT applied for bimodal wave spectra and a comparison of the accuracy and validity of other wave force formulae. The peak forces and peak pressures distribution obtained by spectral wave theory compare well to the measurements. It appears that the use of a spectral LWT to obtain characteristic extreme forces improves the accuracy of the extreme load more than the use of a second order wave model with a quasi-regular assumption (i.e. where the spectral shape is not considered). For the typical conditions that occur at hydraulic structures (horizontal bed, intermediate to deep water, non-breaking, and uni- and bimodal seas) the often-used Goda formula can both under of overestimate the peak loads. Goda is well applicable for conditions with (breaking) waves narrow wave spectra and values of kph <0.5.Hydraulic Structures and Flood Ris
Primary central nervous system lymphoma: Comprehension of cell-of-origin subtypes
No full textPrimary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is an uncommon extranodal lymphoma that accounts for more than 95% of all the CNS lymphomas. Unlike its systemic/nodal counterpart, which is currently subtyped into cell-of origin (COO) subtypes, its feasibility and utility are largely debatable in PCNS-DLBCL.
Objectives:
To classify PCNS-DLBCL into COO-subtypes based on immunohistochemical algorithms by Hans and Choi and evaluate concordance between the two. A further aim is to investigate the clinicoradiological and histomorphological parameters of the subtypes thus obtained.
Materials and Methods:
As many as 143 cases of primary CNS lymphoma were evaluated by immunohistochemistry for CD10, BCL6, MUM1, GCET, and FOXP1 and based on which the said 143 cases were further classified into COO subtypes using Hans and Choi algorithms.
Results:
Mean age was 53.8 years with marginal male preponderance and predominantly centroblastic morphology (75.5%). CD 10 was positive in 8.9% of the cases, BCL6 in 58.6%, MUM1 in 89.9%, GCET in 32.9%, and FOXP1 in 79.5%. As much as 84.9% cases were of non-germinal center B-cell (GCB) subtype and 15.1% cases were of GCB subtype as determined based on Hans algorithm. Furthermore, 90.7% cases were of activated B-cell (ABC) subtype and 9.3% cases were of GCB subtype according to Choi algorithm. A 91.8% concordance was observed between Hans and Choi algorithms. Among the 6 discordant cases, 5 cases were subtyped as GCB by Hans and ABC by Choi and 1 case as ABC by Hans and GCB by Choi.
Conclusion:
Most of PCNS-DLBCLs are of non-GCB/ABC COO subtype, but inconsistences abound in the utility of IHC algorithms in PCNS-DLBCL COO subtypes
Coagulation and anticoagulation in acute lung injury, pneumonia, and ventilator-associated lung injury
No full textHonour and Dignity Invasion in Newspapers
No full textAutors maģistra darbā ir aplūkojis goda un cieņas aizskārumu preses izdevumos. Maģistra darba mērķis ir analizēt goda un cieņas aizskāruma veidus preses izdevumos, goda un cieņas kolīziju ar vārda brīvību, kā arī kompensācijas apmēra noteikšanu.
Maģistra darba pirmajā nodaļā tiek analizēts goda un cieņas jēdziena saturs un to izpratne tiesu praksē.
Nākamajās nodaļās ir apskatīts goda un cieņas civiltiesiskais regulējums, goda un cieņas un vārda brīvības kolīzija, kā arī analizēti privātpersonu un publisku personu goda un cieņas aizsardzības aspekti. Darba pēdējā nodaļā autors ir aplūkojis kompensācijas noteikšanas problemātiku par goda un cieņas aizskārumu. Praktiskajā darba daļā pētīta un salīdzināta dažāda tiesu prakse. Darba nobeigumā sniegti secinājumi goda un cieņas tiesiskās aizsardzības regulējuma turpmākai attīstībai, kā arī izteikti priekšlikumi, lai piedāvātu labāko rīcības modeli goda un cieņas aizsardzībai Latvijā.The author of the master’s thesis has examined the concept of honour and dignity in press. The purpose of the paper is to analyze the defamation ways in newspapers, the honour and dignity conflict with the freedom of expression, as well as determination of compensation.
In the first chapter author analyzes the concept of honour and dignity and their respective understanding in legal practise.
In the following sections author has analyzed the legal regulation regarding honour and dignity, the conflict of honour and dignity with the freedom of speech including private and public person honour and dignity protection aspects. Opening the last chapter, the author is addressing problems of the refund of the defamation offense. In the practical part of the paper different legal rulings are analyzed and compared. Finally the author of the paper gives conclusions on further development of regulation of legal protection of the concepts of honour and dignity, as well as puts forward some suggestions to propose the best model that can be used by Latvia in order to protect person’s honour and dignity
The effect of sensory integration on balance and coordination in the early rehabilitation of children with pervasive developmental disorder.
No full textABSTRACT Vilnius University Faculty of Medicine Health Sciences Institute Department of Rehabilitation, Physical and Sports Medicine Bachelor’s Degree of Physiotherapy THE EFFECT OF SENSORY INTEGRATION ON BALANCE AND COORDINATION IN THE EARLY REHABILITATION OF CHILDREN WITH PERVASIVE DEVELOPMENTAL DISORDER Physiotherapy Bachelor's Thesis The Author: Goda Pertikaitė, 4th year student of Bachelor‘s Degree in Physiotherapy at Vilnius University, Faculty of Medicine. Academic supervisor: lector Agnė Juodytė, Vilnius University, Faculty of Medicine, Institute of Health Sciences, Department of Rehabilitation, Physical and Sports Medicine. Keywords: pervasive developmental disorder, sensory integration, balance, coordination, early rehabilitation. The aim of research work: to evaluate the impact of sensory integration on balance and coordination in the early rehabilitation of children with pervasive developmental disorder. Tasks of work: 1. To identify and evaluate the impact of sensory integration on the balance of children with pervasive developmental disorder. 2. To identify and evaluate the impact of sensory integration on the coordination of children with pervasive developmental disorder. Materials and methods: the study was conducted in 2023-2024 at Vilnius, Child Development Clinic. The study included 24 (n=24) subjects aged 3-7 years with pervasive developmental disorders. The patients were divided into two groups: Group I (n=12) received traditional physiotherapy and Group II (n=12) received traditional physiotherapy combined with sensory integration activities. In total, 10 treatments were performed. Methods: "Time & Up and Go" test, the "Pediatric Balance Scale" and the "Non-Balance Coordination Samples". The tests were carried out before and after the 10 physiotherapy sessions. Statistical data analysis was performed using MS Excel and R 3.6.1 statistical data analysis packages. Data are considered statistically significant at p<0,05. Results: the results of the "Time Up and Go" test, the "Pediatric Balance Scale" and the "Non-Balance Coordination Samples" showed a statistically significant difference between the first and second examination. However, none of the tests showed a statistically significant difference between the groups at the second examination. Conslusions: 1. The study found a statistically significant difference between the primary and secondary assessments after the interventions, but concluded that sensory integration did not have a statistically significant positive effect on the balance of children with pervasive developmental disorders in early rehabilitation. 2. The study found a statistically significant difference between the primary and secondary assessments after the interventions, but concluded that sensory integration did not have a statistically significant positive effect on the coordination of children pervasive developmental disorders in early rehabilitation
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