1,311 research outputs found
Glutamicibacter arilaitensis WD
No full textDescription of Glutamicibacter arilaitensis WD 9 Cells are Gram-stain-positive, non-flagellated, non-pigmented, and rod-coccus shaped. Colonies are circular, smooth, convex, opaque, and pale-yellow colored after 2 days on MA at 25°C. Nitrate is reduced and esculin is hydrolyzed. The strain shows positive reactions for enzyme activities of gelatinase and β -galactosidase, whereas the strain shows negative reactions for enzyme activities of arginine dihydrolase, urease, and oxidase. Indole is not produced and glucose is not fermented. The strain utilizes D-glucose, L-arabinose, D-maltose, potassium gluconate, adipic acid, malic acid, trisodium citrate, and phenylacetic acid, whereas the strain does not utilize D-mannose, D-mannitol, N -acetyl-glucosamine, and capric acid. Strain WD9 (= NIBRBAC000501125) was isolated from seawater, Wando, Jeollanam Province, Korea.Published as part of Kim, Mi-Sun, Jeong, Seong-Hwa, Kang, Joo-Won, Kim, Seung-Bum, Cho, Jang-Cheon, Cha, Chang-Jun, Im, Wan-Taek, Bae, Jin-Woo, Lee, Soon-Dong, Kim, Won-Yong, Kim, Myung-Kyum & Seong, Chi-Nam, 2019, Unrecorded prokaryotic species belonging to the class Actinobacteria in Korea, pp. 97-108 in Journal of Species Research 8 (1) on page 105, DOI: 10.12651/JSR.2019.8.1.097, http://zenodo.org/record/812047
A systems biological investigation into the dual roles of RCAN1 in the calcineurin-NFAT signaling network
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Full and ideal mixing behavior between Zr-Wd (K2ZrSi3O9) and Ti-Wd (K2TiSi3O9): evidences from mineral chemistry, X-ray diffraction pattern and Raman spectrum
No full textA series of wadeite solid solutions (Wd(ss)) along the join K2ZrSi3O9 (Zr-wadeite, Zr-Wd)-K2TiSi3O9 (Ti-wadeite, Ti-Wd) was synthesized at 2 GPa and 1,200-1,400 A degrees C for 24 h with a piston-cylinder apparatus. The chemical composition data demonstrated that Ti and Zr readily substitute for each other, and a full series of Wd(ss) exists between the Zr-Wd and Ti-Wd end-members at the P-T conditions of our synthesizing experiments. The volume-composition relationship at ambient P-T conditions did not show any significant deviation from the Vegard's law, indicating a nearly ideal mixing between the Zr-Wd and Ti-Wd. All the Raman peaks observed at ambient P-T conditions were linearly correlated with the composition, suggesting an almost full structural relaxation for the Wd(ss). These findings suggest that the complete mixing behavior along the join K2ZrSi3O9-K2TiSi3O9, as demonstrated by our high-P experiments, may extend to a much wider range of P-T conditions. Consequently, the coexistence of the Zr-Wd and Ti-Wd in the lamproites from the Leucite Hills, Wyoming, may be due to a chemical composition change of the magma rather than a crystal structural limit.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350310900006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Materials Science, MultidisciplinaryMineralogySCI(E)[email protected]
Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene
No full textWilson disease (WD), an inherited disorder affecting copper metabolism, is characterized by hepatic cirrhosis and neuronal degeneration, which result from toxic levels of copper that accumulate in the liver and brain, respectively. We reported previously that the approximate to1.3-kb promoter of the WD gene contains four metal response elements (MREs). Among the four MREs, MREa plays the most important role in the transcriptional activation of the WD promoter. Electrophoretic mobility shift assays (EMSAs) using synthetic MREa and an oligonucleotide containing the binding site for transcription factor Sp1 revealed the presence of nuclear factors that bind specifically to MREa. Two MREa-binding proteins of 70 and 82 kDa were purified using avidin-biotin affinity chromatography. Amino acid sequences of peptides from each protein were found to be highly homologous to the Ku proteins. Immunoblot analysis and EMSAs showed that the MREa-binding proteins are immunologically related to the Ku proteins. To study further the functional significance of these Ku-related proteins in transcriptional regulation of the WD gene, we performed RNA interference (RNAi) assays using a Ku-80 inverted-repeat gene to inhibit expression of the Ku-80 gene in vivo. Results of the RNAi assays showed that expression of the Ku-80 protein was suppressed in transfected cells, which in turn led to the suppression of the WD gene. In addition, a truncated Ku-80 (DeltaKu-80) mutant inhibited WD promoter activity in HepG2 cells in a dominant-negative manner. We also found that WD promoter activity was decreased in Xrs5 cells, which, unlike the CHO-K1 cells, are defective in the Ku-80 protein. When Ku-80 cDNA was transfected into Xrs5 and CHO cells, WD promoter activity was recovered only in Xrs5 cells. Taken together, our findings suggest that the Ku-80 subunit is required for constitutive expression of the WD gene
Fly-By-Wireless for Next Generation Aircraft: Challenges and Potential solutions
No full text”Fly-By-Wireless” paradigm based on wireless connectivity in aircraft has the potential to improve efficiency and flexibility, while reducing weight, fuel consumption and maintenance costs. In this paper, first, the opportunities and challenges for wireless technologies in safety-critical avionics context are discussed. Then, the assessment of such technologies versus avionics requirements is provided in order to select the most appropriate one for a wireless aircraft application. As a result, the design of a Wireless Avionics Network based on Ultra WideBand technology is investigated, considering the issues of determinism, reliability and security
Surface order in thin films of self-assembled columnar liquid crystals
No full textThe way in which alignment of hexagonal columnar mesophases depends on molecular structure, film thickness, and surface interactions is investigated. Homeotropic orientation of tapered nonpolymeric and polymeric amphiphilic columnar molecules occurs most readily on carbon substrates. The planar alignment of asymmetric dendrimers is favored on a water surface but is not possible for a symmetric dendrimer. For the polymeric material, film thickness has a significant influence on the morphology. Thick films align homeotropically, but films that are only a few column diameters in thickness are planar, and their thickness is quantized. Because they must contain an integral number of layers of cylinders, the resulting morphology is terraced.This work was supported by the
Center for Ultramicrochemical Process Systems, Advanced
Backbone IT Technology Development Project,
the Brain Korea 21 Project, and NSF (DMR-99-96288)
Diversity of tumor vascularity and apparent diffusion coefficients (ADCs) of well-differentiated hepatocellular carcinomas (wd-HCCs).
No full textA nonhypervascular wd-HCC on the arterial phase image (upper left) and the corresponding subtraction postcontrast image (upper middle) has a low ADC value (0.928 × 10−3 mm2/s) in the polygonal region of interest (ROI) on the ADC map (upper right). In another patient, a markedly hypervascular wd-HCC on the arterial phase image (lower left) and the corresponding subtraction postcontrast image (lower middle) shows a high ADC value (1.388 × 10−3 mm2/s) in the polygonal ROI on the ADC map (lower right).</p
Structural and neurochemical evaluation of the brain and pons in patients with Wilson's disease (vol 28, pg 663, 2010)
No full textThe aim of this study was to examine the structural-neurochemical abnormalities of the frontal white matter (FWM), deep gray matter nuclei, and pons in patients with Wilson's disease (WD) using proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI).
Nine patients with WD and 14 age-matched controls were examined with MRS. N-Acetylaspartate (NAA), choline (Cho), and creatine (Cr) peaks were calculated. DWI scans from six WD patients and six controls were also obtained. The relative metabolite ratios and apparent diffusion coefficient (ADC) values of the WD patients were compared to those of the control subjects by using statistical measures.
Measurements in the thalamus and pons showed significantly lower NAA/Cho and NAA/Cr ratios in the WD group than in the control group (P 0.05).
MRS is a noninvasive, valuable modality for detecting structural-neurochemical changes of the brain stem and deep gray matter in patients with WD. The contribution of DWI in these patients is limited
Optical properties of SiO x nanostructured films by pulsed-laser deposition at different substrate temperatures
No full text10.1063/1.1782274Journal of Applied Physics9663180-3186JAPI
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